Could this be a survival data problem? Harzard ratio are hazardous (check pmc.ncbi.nlm.nih.gov/articles/PMC... ). Could this be a MR problem (life course effect vs specific effect in cancer patients)? Let me know if you have any thoughts on this!

First, the reported SNP failed to associate in independent data sets, then the MR with genetically proxied PCSK9 levels was not significant. Finally, we tried MVMR to correct for potential influence from lipids, but still observed no effect.

📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.

We also compare fixing taxon traceability to the gold standard, phylogenetic decisiveness. Thanks to my master thesis supervisor Mareike Fischer for continuing on this project, keeping me in on it, and especially for proving the bounds!

We provide here an algorithm (implemented in R, package available at github.com/pottj/Fixing...) and some bounds for this nice set of taxon sets.

Fixing taxon traceability (simplified): assume n taxa and k sets of quadruples defining a tree each. Then the set of k quadruples is fixing taxon traceable if all missing quadruples have a fixing taxon or can be resolved using the input quadruples + those with fixing taxa.

Fixing taxon: assume 5 taxa and only 4 of 5 possible trees available. Then one taxon is in all trees (e.g. taxon 3 in the quartet trees on the left, combination of Figure 1, 2, and 4 of the publication), the supertree is already defined (tree on the right), and hence the "missing" tree too!

📣Paper alert!
(Spoiler: this is not my usual GenEpi paper 😁 #phylogenetics)
How many small trees do you need to define one supertree? Mareike Fischer and I explored this question and defined a subclass of taxon sets that guarantees decisiveness aka one supertree
link.springer.com/article/10.1...