Chris Nickson
@precordialthump.bsky.social
Intensivist, ECMO specialist, Clinician Educator. Calm amid a #FOAMed storm: LITFL.com & INTENSIVEblog.com
Reposted by Chris Nickson
Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses
December 10, 2025 at 8:15 PM
Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses