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#NeuroDegeneration preprints

@prepub-neurodegen.bsky.social

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#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 8h

Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community cohorts #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.02.25331921v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 8h

Unmasking Early Microglial Remodeling in an Alzheimer's Disease Mouse Model #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.681006v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 8h

Sex Differences in the Relationship of Biomarker Change to Memory Decline in Early Alzheimer’s Disease: an Observational Cohort Study #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-7661592/latest

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 8h

Linking COVID-19 to Neurodegeneration: A Single-Cell Deep Learning Study of PBMCs in Multiple Sclerosis and Alzheimer’s Disease #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-7342199/latest

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

The Polynomial Progression Subtype Inference Algorithm #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-7199106/latest

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Comparative analysis of T-cell signatures and astroglial reactivity in Parkinson's pathology across animal models with distinct regenerative capacities #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680901v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Glucocorticoids regulate small extracellular vesicle (sEV) release via activation of nSMase2 #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680983v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Deveolopment of patient-derived neuroprogenitor cells (hNPCs), neurons, and astrocytes to explore the etiology of Guam Parkinsonism-dementia complex (PDC) #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680309v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Functional specialization of the hippocampus along its dorso-ventral axis: from span to supraspan in working memory capacity #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680879v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 neurodegeneration model #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680869v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Mitoxantrone Hydrochloride Targets APP and LRRK2 to Improve Neurodegeneration in Parkinson's Models #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.06.680832v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.07.680938v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Neuro: Machine Learning Optimized to Detect Neurodegenerative Diseases Pilot Study #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.09.29.25336770v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Aquaporin-4 polymorphisms modify the penetrance of Parkinson's disease in leucine-rich repeat kinase 2 carriers #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.04.25337325v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Microglia-specific polygenic risk stratification reveals distinct pathological subtypes in Alzheimer's disease #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.06.25336925v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 17h

Beyond amyloid and tau: synaptic and neurodegenerative biomarkers shape MCI progression #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.06.25337445v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

LACK OF OXYGEN AND/OR GLUCOSE DIFFERENTIALLY POTENTIATES Aβ40EQ22- AND Aβ42-INDUCED CEREBRAL ENDOTHELIAL CELL DEATH, BARRIER DYFUNCTION AND ANGIOGENESIS IMPAIRMENT #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.05.680546v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.06.677012v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.03.680233v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

Alzheimer's disease causes bone marrow myelopoiesis dysfunction #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.06.680030v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

ER oxidoreductin-1α and unfolded protein response as sex-dependent drivers of cardiorenal dysfunction in experimental autoimmune encephalomyelitis #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.06.680703v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

XIST Self-regulates its Association with THOC2 and the Nuclear Epigenetic Machinery via miR-186 in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.05.680468v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

A molecular convergence in the triad of Parkinson's disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.05.680533v1

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

What your brain activity says about you: A review of neuropsychiatric disorders identified in resting-state and sleep EEG data #NeuroDegeneration 🧪🧠
https://arxiv.org/abs/2510.04984

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 1d

Beyond P-values: A Multi-Metric Framework for Robust Feature Selection and Predictive Modeling #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.05.680380v1