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Stephen J. Tucker @profkalium.bsky.social · 4d

That’s because you are further North!

Stephen J. Tucker @profkalium.bsky.social · 26d

Translational ion channel research at its best. The 2025 Lasker~DeBakey Clinical Medical Research Award goes to Michael Welsh, Tito González, and Paul Negulescu for their role in developing a novel drug treatment for cystic fibrosis.

Targeting cystic fibrosis where it counts

YouTube video by Albert and Mary Lasker Foundation

youtu.be

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Stephen J. Tucker @profkalium.bsky.social · Sep 6

Cocaine-activated ion channels... www.nature.com/articles/s41...

Cocaine chemogenetics blunts drug-seeking by synthetic physiology - Nature

Cocaine chemogenetics in rats is a selective approach for countering drug reinforcement by clamping dopamine release in the presence of cocaine.

www.nature.com

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Stephen J. Tucker @profkalium.bsky.social · Aug 27

Fantastic to see @richardsever.bsky.social and John Inglis honoured with this award for their contribution to @biorxivpreprint.bsky.social and the way preprints have transfomed scientific communication in the biosciences.

Richard Sever @richardsever.bsky.social · Aug 27

Very honored to receive the Royal Society Research Culture Award - this represents the work of a great team who've worked non-stop since we launched bioRxiv in 2013 royalsociety.org/news/2025/08... www.cshl.edu/inglis-and-s...

Invisibility cloak pioneer Sir John Pendry awarded Royal Society’s top prize | Royal Society

The Royal Society announces the medals and awards recipients 2025

royalsociety.org

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Stephen J. Tucker @profkalium.bsky.social · Aug 20

Great new work from the Newstead & Bennett labs @ox.ac.uk

www.nature.com/articles/s41...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

www.nature.com

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Reposted by Stephen J. Tucker

Ardem Patapoutian @ardemp.bskyverified.social · Aug 13

Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...

TRYPTYR (acoltremon ophthalmic solution) 0.003% eye drops | Alcon US

TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.

tryptyr.myalcon.com

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Reposted by Stephen J. Tucker

profserious @profserious.bsky.social · Aug 10

Very few people seem to understand university finances and, distressingly, this includes many academics and most policymakers. This is an attempt to condense the key points you need to know. open.substack.com/pub/profseri...

Understanding University Finances

... a very short guide

open.substack.com

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Stephen J. Tucker @profkalium.bsky.social · Aug 6

Our latest preprint on the mechanism of GqPCR regulation of TASK K2P channels. biorxiv.org/content/earl...

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Stephen J. Tucker @profkalium.bsky.social · Jul 30

Open to applicants currently based overseas, the Accelerated International Route provides up to £4 million over a five-year period to outstanding mid-career STEM researchers looking to relocate to the UK.

Faraday Discovery Fellowships Accelerated International Route | Royal Society

The Faraday Discovery Fellowships Accelerated International Route provides a fast-track option for attracting mid-career researchers looking to relocate to the UK from overseas, providing up to £4m ov...

royalsociety.org

Reposted by Stephen J. Tucker

Dan Minor @electrosomeucsf.bsky.social · Jun 15

New work from our lab. Structures of K2P6.1 (TWIK2) that yield a new and suprising perspective on how lipids affect K2P channels. Great work from Abishek Mondal and Sangeeta Niranjan in my lab.

www.biorxiv.org/content/10.1...

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Reposted by Stephen J. Tucker

The Royal Society @royalsociety.org · Jun 4

We are reviewing the current state of scientific publishing, and we want to hear from researchers on their perceptions of publishing in the current context and how it might develop in future. Complete our short survey now:

The Future of Scientific Publishing - survey

forms.royalsociety.org

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Reposted by Stephen J. Tucker

Wojciech Kopec @wojciechkopec.bsky.social · May 22

www.qmul.ac.uk/media/news/2...

Electrophysiology at atomic resolution: scientists simulate ion channel currents with unprecedented accuracy

www.qmul.ac.uk

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Stephen J. Tucker @profkalium.bsky.social · May 16

Fascinating new study on origin of thermosensitivity in TREK K2P channels....

link.springer.com/article/10.1...

Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network - Pflügers Archiv - European Journal of Physiology

Temperature sensing is an essential component of animal perception and enables individuals to avoid painful or lethal temperatures. Many temperature sensors in central and peripheral neurons are ion c...

link.springer.com

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Stephen J. Tucker @profkalium.bsky.social · May 15

I keep nibbling away when I have time - do you have a mechanism for recruitment of new affiliates? I'm sure more people would be willing to help if they knew how.

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Stephen J. Tucker @profkalium.bsky.social · May 8

Great news - well done!

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Reposted by Stephen J. Tucker

Steve Wang @stevewang251.bsky.social · Apr 26

Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator.
#academicsky

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Stephen J. Tucker @profkalium.bsky.social · Apr 25

Fascinating new work and CryoEM structures from Stephen Long's group showing the BEST Cl- channel is regulated by extracellular GABA | PNAS www.pnas.org/doi/10.1073/...

The pentameric chloride channel BEST1 is activated by extracellular GABA | PNAS

Bestrophin-1 (BEST1) is a chloride channel expressed in the eye and other tissues of the body. A link between BEST1 and the principal inhibitory ne...

www.pnas.org

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Stephen J. Tucker @profkalium.bsky.social · Apr 23

Great work from colleagues @ndcnoxford.bsky.social describing structures of the human adult muscle-type nicotinic
receptor in resting and desensitized states.

www.cell.com/cell-reports...

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Reposted by Stephen J. Tucker

Greg Jenner @gregjenner.bsky.social · Apr 23

Someone on Threads noticed you can type any random sentence into Google, then add “meaning” afterwards, and you’ll get an AI explanation of a famous idiom or phrase you just made up. Here is mine

• Al Overview
The idiom "you can't lick a badger twice" means you can't trick or deceive someone a second time after they've been tricked once. It's a warning that if someone has already been deceived, they are unlikely to fall for the same trick again.
Here's a more detailed explanation:
• Licking: "Licking" in this context means to trick or deceive someone.
• Badger: The badger is a wild animal, and the phrase likely originates from the historical sport of badger baiting where dogs were used to harass

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Reposted by Stephen J. Tucker

Ash Jogalekar @ashjogalekar.bsky.social · Apr 19

Friday night levity: Only my old professor Fred Menger could start an important paper this way and get away with it. He's always been a hoot, and a brilliant hoot to boot.

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Reposted by Stephen J. Tucker

Chris Lintott @chrislintott.bsky.social · Apr 17

At some point we need to have a discussion about the ethics of participation in press releases as scientists. From today’s K2-18b saga, Nikku Madhusudhan in the press release says ‘The signal came through loud and clear’ (1/n)

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Stephen J. Tucker @profkalium.bsky.social · Mar 31

Stand up for what is right. No excuses need to be made.

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Stephen J. Tucker @profkalium.bsky.social · Mar 31

Two days of Ion Channels on the beautiful Hinxton Hall Genome Campus talking about the work from my team @kavlioxford.bsky.social #IonChannels25

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Reposted by Stephen J. Tucker

Hugues Nury @hugbum.bsky.social · Mar 27

New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state.
www.biorxiv.org/content/10.1...

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Reposted by Stephen J. Tucker

Ed Twomey @cryoet.bsky.social · Mar 26

Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.

www.nature.com/articles/s41...
www.nature.com/articles/d41...

Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com

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