Lightnews — Scholar-powered news

Louise Marston @proflouisemarston.bsky.social · 1d

Evidence for health promotion interventions to improve cognitive and physical functioning outcomes in older adults with MCI: A state-of-the-art review www.sciencedirect.com/science/arti... @ucl-caps.bsky.social @ucl-primarycare.bsky.social @drmegs.bsky.social @tasminrookes.bsky.social

Background
Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population.
Aim
To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI.
Design
State-of-the art review
Method
Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure.
Results
From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing.
Conclusion
There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.

1 3

Reposted by Louise Marston

UCL primary care and population health @ucl-primarycare.bsky.social · 12d

📢 New Publication Alert
Congratulations to @Roganie Govender and the entire team on their latest publication! A fantastic achievement!
@ucl-primarycare.bsky.social
bmjopen.bmj.com/content/15/9...

Swallowing prehabilitation for people with head and neck cancer: a pilot cluster-randomised feasibility trial of the SIP SMART intervention

Objectives To assess the feasibility of delivering the swallowing prehabilitation intervention known as Swallowing Intervention Package: Self-Monitoring, Assessment and Rehabilitation Training (SIP SM...

bmjopen.bmj.com

2 1

Louise Marston @proflouisemarston.bsky.social · 15d

Insult to Muppets and Sesame Street characters.

1 2

Reposted by Louise Marston

UK CTU Network @ukcrc-ctu.org.uk · 22d

Every data point tells a story.

Statisticians ensure those stories are heard—spotting safety concerns, reducing bias, and ensuring ethical outcomes in clinical trials.

🔗 ukcrc-ctu.org.uk

#Statistics #UKCTUNetwork #WorldPatientSafetyDay2025

1 1

Louise Marston @proflouisemarston.bsky.social · 27d

I have just been bought this!

1

Louise Marston @proflouisemarston.bsky.social · 27d

It is towards the end of our protocol templates...

1 1

Reposted by Louise Marston

UCL primary care and population health @ucl-primarycare.bsky.social · Sep 4

📢 New dataset drop!
The BRHS @ucl-brhs.bsky.social is now available via @ukdataservice.bsky.social 🎉
🔗 ukdataservice.ac.uk
7,735 men tracked over 50 years = goldmine for research on heart health, ageing & behaviour.
Prof. Wannamethee: “Unparalleled insights into ageing & heart health.”

1

Louise Marston @proflouisemarston.bsky.social · Sep 3

Some on the Sainsbury's website...though not the Taste the Difference, with alcohol one yet.

I might need to go pudding shopping in the name of research.

Louise Marston @proflouisemarston.bsky.social · Sep 3

In other news, I finished my last Christmas pudding from last Christmas this week.

1

Louise Marston @proflouisemarston.bsky.social · Sep 3

Some Christmas products in Morrisons, but do not think there is cake yet.

Louise Marston @proflouisemarston.bsky.social · Aug 15

The colour matches Mr Bump!

1 1

Reposted by Louise Marston

JAMA @jama.com · Aug 10

📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research.

ja.ma/4fzMVZS

Figure. SPIRIT 2025 Diagram of the Schedule of Enrollment, Interventions, and Assessments

20 32

Louise Marston @proflouisemarston.bsky.social · Jul 31

Analysis plan for the main trial analysis paper - published because COVID-19 intervened with the trial and we changed some of the analyses due to that: COVID-19 and the Physio4FMD trial: Impact, mitigating strategies and analysis plans www.sciencedirect.com/science/arti...

COVID-19 and the Physio4FMD trial: Impact, mitigating strategies and analysis plans

Functional motor disorder (FMD) is a common cause of disabling neurological symptoms such as weakness and tremor. Physio4FMD is a pragmatic, multicent…

www.sciencedirect.com

1

Louise Marston @proflouisemarston.bsky.social · Jul 31

Trial protocol paper: Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder. bmcneurol.biomedcentral.com/articles/10....

Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder - BMC Neurology

Background Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait. Physiotherapy is usually cons...

bmcneurol.biomedcentral.com

1 1

Louise Marston @proflouisemarston.bsky.social · Jul 31

Planned secondary analysis: Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention. www.sciencedirect.com/science/arti...

1

Louise Marston @proflouisemarston.bsky.social · Jul 31

Health economic outcomes: Cost Utility of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD)
Economic Analysis of a Pragmatic Randomised Controlled Trial www.neurology.org/doi/10.1212/...

Cost Utility of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD) | Neurology Clinical Practice

Background and ObjectivesFunctional motor disorder (FMD), a motor-dominant variant of functional neurologic disorder, is a disabling condition associated with high health and social care resource use ...

www.neurology.org

1

Louise Marston @proflouisemarston.bsky.social · Jul 31

Read our papers: Main clinical outcomes Specialist physiotherapy for functional motor disorder in England and Scotland (Physio4FMD): a pragmatic, multicentre, phase 3 randomised controlled trial www.sciencedirect.com/science/arti... in @thelancetneuro.bsky.social

Specialist physiotherapy for functional motor disorder in England and Scotland (Physio4FMD): a pragmatic, multicentre, phase 3 randomised controlled trial

Functional motor disorder—the motor variant of functional neurological disorder—is a disabling condition that is commonly associated with poor health …

www.sciencedirect.com

1

Louise Marston @proflouisemarston.bsky.social · Jul 31

Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT NIHR report out today www.journalslibrary.nihr.ac.uk/hta/MKAC9495 @nihr.bsky.social @ucl-primarycare.bsky.social @gnielsenphysio.bsky.social @jonstoneneuro.bsky.social

1 1 2

Louise Marston @proflouisemarston.bsky.social · Jul 31

Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial @nihr.bsky.social report out today. @ucl-primarycare.bsky.social www.journalslibrary.nihr.ac.uk/hta/GJPS6321

Front page of the MePFAC HTA report with abstract.

Reposted by Louise Marston

UCL Institute of Epidemiology and Health Care @ucliehc.bsky.social · Jul 2

Want to help shape national dementia prevention strategies?

We're looking for a Research Assistant on the PRACTICAL study ▶️ www.ucl.ac.uk/work-at-ucl/...

Closing date: 13 Jul 2025
@ucl-primarycare.bsky.social

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk

2 2

Reposted by Louise Marston

UCL primary care and population health @ucl-primarycare.bsky.social · Jun 10

🎉 Huge congratulations to our PhD candidate, Dennis Emaralino, for successfully passing his PhD upgrade last week! His project, Anxiety, Depression, and Mental Wellbeing Among Young Adults in the Philippines. Very well done! 👏

2 2

Louise Marston @proflouisemarston.bsky.social · Jun 7

Freezing here. And raining.

1

Reposted by Louise Marston

UCL Institute of Epidemiology and Health Care @ucliehc.bsky.social · Jun 1

We're excited to advertise a permanent role as a Clinical Lecturer in Primary Care (0.6FTE) in our Institute for a GP holding a PhD or equivalent qualification who would like to develop a career as an academic in research and education.

Click here for more details: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk

1 1

Louise Marston @proflouisemarston.bsky.social · Jun 1

Wow! Well done. That is a lot of km.

1

Louise Marston @proflouisemarston.bsky.social · May 31

I remember now, they went with your dress and shrug. I am thinking orange and blue