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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 1d

I’m wondering if I’m paranoid but we’re 3000+ injections now and we’ve never cleaned the Ultra2 - and I like it that way…

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 1d

Interesting! We’ve never once went above 20ng…

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 1d

10ng is a little better than 2ng but I don’t see an advantage at this flow rate going higher. Maybe with ICC? (AGC)

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Reposted by ProteomicsNews (Ben Orsburn)

PastelBio @pastelbio.bsky.social · 2d

msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data www.biorxiv.org/cont...

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#proteomics #prot-preprint

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 2d

We’ve tried a range between 2-10ng on column and didn’t think ICC would be necessary. Library is the same predicted human we use for everything. I’d love a better suggestion!

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 2d

Okay y’all. I’m at a complete loss. DIA is better on EVERYTHING on my Ultra2 except plasma digests. Neat, PC, PCA-N. DDA (pasef) works better. Coisolation FDR artifact? Anyone else see this?

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 7d

I didn't know there were 15 human body fluids.... but the preprint is missing key information. I couldn't reproduce this study with the methods provided. Were bands cut out of gels and then FASP'ed? How many bands? Cool topic, tough read.

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 7d

GO FAST with InfinDIA!! proteomicsnews.blogspot.com/2025/10/tire...

Tired of slow DIA search times? Try DIA-NN 2.3 with InfinDIA!

Is your awesome new instrument generating so much data that you can't process it fast anymore? My data density has jumped about 5x from my...

proteomicsnews.blogspot.com

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 12d

Cool…. ‘Cause US kids are totally lining up for 10 years of student loan debt for mid-tier salary jobs in academia.

Reposted by ProteomicsNews (Ben Orsburn)

Bénédicte C @benecal.bsky.social · 13d

The WSJ Editorial Board is sick of RFK too.

"What’s going on here has less to do with healthcare than with a campaign by the plaintiffs bar."

Apparently RFK's trying to influence the appeals for a case his buddies lost against Tylenol.

www.wsj.com/opinion/tyle...

Opinion | Trump, Tylenol and the Plaintiffs Bar

The acetaminophen link to autism is based on weak evidence pushed by RFK Jr. and his legal allies.

www.wsj.com

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Reposted by ProteomicsNews (Ben Orsburn)

Mathieu Lavallée-Adam @mlaval6.bsky.social · 13d

Great conversation! Lots of fun! Thank you @proteomicsnews.bsky.social and @benneely.com for the invitation! #TheProteomicsShow. And we talked #HUPO2025 for which the regular registration deadline is tomorrow (Sept. 26) #TeamMassSpec #Proteomics #Bioinformatics

Ben Neely @benneely.com · 13d

Continuing our highlight of the upcoming #HUPO2025 in TO, we had @mlaval6.bsky.social on #THEProteomicsShow with me and Ben @proteomicsnews.bsky.social. We don’t know hockey, but we still talked cool bioinformatics stuff. Find it wherever you find fine podcasts or here anchor.fm/theproteomic...

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 13d

That was fast!

Ben Neely @benneely.com · 13d

Continuing our highlight of the upcoming #HUPO2025 in TO, we had @mlaval6.bsky.social on #THEProteomicsShow with me and Ben @proteomicsnews.bsky.social. We don’t know hockey, but we still talked cool bioinformatics stuff. Find it wherever you find fine podcasts or here anchor.fm/theproteomic...

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

I snapped a picture of everyone (including organizers from both @us-hupo.org and @hupo-org.bsky.social )from today's workshop. Thanks for inviting me. It's a topic I wouldn't have thought of on my own.

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

US HUPO / HUPO ECR sound checks in progress! us-hupo.org/Webinars

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

Yeah! There's a market. On the new ones they took the blue plastic off of them and - best I can tell -changed nothing else! Except they don't make them in Austin (you can guess where) and the bolts are easier to strip/break. www.thermofisher.com/order/catalo...

ISQ™ 7610 Single Quadrupole GC-MS AEI Ion Source | Request for Quote

ISQ™ 7610 Single Quadrupole GC-MS. Experience unstoppable efficiency in your analysis and ensure regulatory demands are met with the Thermo Scientific ISQ 7610 Single Quadrupole GC-MS system. Availabl...

www.thermofisher.com

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

Early Career Researcher- No cap, you can still register for today's webinar on how to maximize your conferences (bruh) us02web.zoom.us/webinar/regi...

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

I wouldn’t have bought several inductively plasma coupled quads over the years if it had! They cost 3-10x as much! No joke, the last new Thermo GC-single quad I ordered was only like $45k.

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 15d

...and disbelief suspension paused....and run ruined when chapter 8 features a scientist trying to figure out what a metal is by GCMS....

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 18d

(It just says Dr. Shelby on it, not Slipknot or In Flames repeatedly)

ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 18d

Right?!! Before we planned this last second experiment (mouse were killed for their brains, we reutilized) I brought up the fact only I have a (Slipknot and In Flames embroidered) lab coat. Shelby got one at her defense party the next night!

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 18d

Oh. We have not. Thank you!

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 18d

YEAH! And Jesse, was this at your home in California? That's a different species than the ones hanging out on my kid's toys in PA!

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 18d

One of my MD collaborators said something like "I don't care what the proteomes are like in cells that incubated in organ dissociation enzymes for 1 hour" 💡I'm happy to report my team can now dissociate cells for single cell proteomics without long enzymatic dissociation! Paper coming fast!

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ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 22d

Wait. Does blog traffic go UP when I’m too busy to post?? Cool. Whateva. Grant 17 of 2025 is go. SilkSong was worth the wait. And NEW LORNA SHORE ALBUM!

ProteomicsNews (Ben Orsburn) @proteomicsnews.bsky.social · 23d

Boo. Different vendor here. Same story. I do NOT like the Ultra9 chips. Those 12 "efficiency" cores are underperforming at multi-thread load. Maybe those 8 "performance" cores are good?

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