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PRIMED Consortium

@prsmethods.bsky.social

160 followers 96 following 37 posts

The NIH-funded Polygenic Risk Methods Development (PRIMED) Consortium. primedconsortium.org

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PRIMED Consortium @prsmethods.bsky.social · Nov 27

Hello Bluesky! The PRIMED Consortium is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations. Read more in our recently published Perspective 🧵 1/ www.cell.com/ajhg/fulltex...

The PRIMED Consortium: Reducing disparities in polygenic risk assessment

To lessen health and healthcare disparities and extend advances in genomic medicine to all, the PRIMED Consortiumis bringing together investigators and datasets from across the globe to develop PRS me...

www.cell.com

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Reposted by PRIMED Consortium

Arun Durvasula @arundurvasula.bsky.social · Sep 2

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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PRIMED Consortium @prsmethods.bsky.social · Aug 25

‪The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!

PRIMED Consortium @prsmethods.bsky.social · Aug 15

👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries

www.medrxiv.org/content/10.1...

Josep Mercader @josepmercader.bsky.social · Aug 15

Sharing a global effort to develop PRSs for T2D in multiple ancestries. www.medrxiv.org/content/10.1... funded by NHGRI @prsdiversity.bsky.social #D_PRISM
Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries

Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermin...

www.medrxiv.org

PRIMED Consortium @prsmethods.bsky.social · Aug 14

📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference

In-person registration closes Aug 19: https:/bit.ly/anvil2025

NHGRI AnVIL @anvilproject.org · Aug 12

⏳ Only 1 Week Left to Register for ACC2025! Register before August 19 to come to Nashville on Sep 3–5! bit.ly/anvil2025

🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free

And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...

AnVIL Community Conference 2025: Abstract Submission Form

Please use this form to submit an abstract (300 word limit) to the AnVIL Community Conference 2025 in Nashville, TN. The conference will take place from September 3-5, 2025. In-person attendance is…

bit.ly

PRIMED Consortium @prsmethods.bsky.social · Aug 1

Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!

www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...

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Reposted by PRIMED Consortium

NHGRI AnVIL @anvilproject.org · Jul 10

🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!

- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual

Don’t miss it!

PRIMED Consortium @prsmethods.bsky.social · Jul 10

Co-authors include @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the Data Sharing Working Group!

@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium

PRIMED Consortium @prsmethods.bsky.social · Jul 10

🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏

See also our thread on the pre-print - bsky.app/profile/prsd...

American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · Jul 10

Data sharing is crucial to advancing health research. @ajhgnews.bsky.social's latest article provides policy recommendations to facilitate future use & sharing of heterogeneous data sources w/ a goal of improving polygenic risk prediction: www.cell.com/ajhg/abstrac... @prsdiversity.bsky.social

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PRIMED Consortium @prsmethods.bsky.social · Jul 2

ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social

www.cell.com/ajhg/abstrac...

Sarah Nelson @blueyedgenes.bsky.social · Jun 17

👀 🧬 Curious how to respectfully, robustly, and flexibly use population descriptors in genomic research, and align with @nationalacademies.org recommendations?

Check out this work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social, co-led by Alyna Khan and Stephanie Gogarten

The American Journal of Human Genetics @ajhgnews.bsky.social · Jun 12

📣New from the PRIMED Consortium!
📄A data model for population descriptors in genomic research

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PRIMED Consortium @prsmethods.bsky.social · Apr 25

Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social!

Genetic information can help improve risk prediction for a broad range of health outcomes.

Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...

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Reposted by PRIMED Consortium

Gen Wojcik @genandgenes.bsky.social · Apr 24

I wrote a thing.

I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.

Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

Nature @nature.com · Apr 24

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics

https://go.nature.com/4jGqiUc

Eugenics is on the rise again: human geneticists must take a stand

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

go.nature.com

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PRIMED Consortium @prsmethods.bsky.social · Apr 9

Find this and other @prsdiversity.bsky.social publications and preprints on our website, primedconsortium.org/publications...

View Publications | PRIMED Consortium

primedconsortium.org

PRIMED Consortium @prsmethods.bsky.social · Apr 9

They also discuss current challenges in fully using local ancestry in genetic epidemiological studies and suggest future directions towards its full usage. 3/

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PRIMED Consortium @prsmethods.bsky.social · Apr 9

Quan Sun and colleagues at the EPIC-PRS PRIMED Site review methods to infer and incorporate local ancestry in various analyses including admixture mapping, association testing, and polygenic prediction. 2/

PRIMED Consortium @prsmethods.bsky.social · Apr 9

👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/
www.sciencedirect.com/science/arti...

Opportunities and challenges of local ancestry in genetic association analyses

Recently, admixed populations make up an increasing percentage of the US and global populations, and the admixture is not uniform over space or time o…

www.sciencedirect.com

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Reposted by PRIMED Consortium

Elizabeth Atkinson @egatkinson.bsky.social · Apr 3

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

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PRIMED Consortium @prsmethods.bsky.social · Apr 2

📣 Call for community feedback!

The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...

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PRIMED Consortium @prsmethods.bsky.social · Mar 12

Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth

Eimear Kenny @eimearekenny.bsky.social · Mar 12

Honored to be featured in ASHG’s #WomensHistoryMonth celebration! Huge thanks to @GeneticsSociety & @sarahtishkoff.bsky.social for the recognition.

Grateful to stand alongside incredible women shaping human genetics & genomics! 💙 #ASHG #WomenInSTEM

www.ashg.org/publications...

Celebrating Women's History Month: Trailblazing Women in Human Genetics and Genomics

ASHG President Sarah Tishkoff, PhD, celebrates women past and present who blaze trails in the human genetics and genomics field.

www.ashg.org

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Reposted by PRIMED Consortium

The Polygenic Score Catalog @pgscatalog.bsky.social · Mar 4

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

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PRIMED Consortium @prsmethods.bsky.social · Feb 27

H/t to co-authors @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the entire Data Sharing Working Group! @prsdiversity.bsky.social is an NHGRI and NCI funded Consortium 7/

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PRIMED Consortium @prsmethods.bsky.social · Feb 27

Additionally, we make recommendations for policy and practice across all these areas, to inform future research and data sharing efforts 6/

PRIMED Consortium @prsmethods.bsky.social · Feb 27

We introduce key policy clarifications and suggested approaches to sharing genomic summary results, such as new polygenic risk score models - a key product of @prsdiversity.bsky.social 5/

PRIMED Consortium @prsmethods.bsky.social · Feb 27

We describe challenges and solutions to sharing the output of harmonizing genotypes and phenotypes given that we are secondary users of pre-existing data sources 4/

PRIMED Consortium @prsmethods.bsky.social · Feb 27

Technical implementation of data sharing in the @anvilproject.org cloud platform includes managing access to data storage and analysis workspaces, and developing new tools and workflows 3/

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PRIMED Consortium @prsmethods.bsky.social · Feb 27

We describe design and implementation of data sharing policies and procedures to bring diverse data together, including coordinated dbGaP applications and a Consortium Data Sharing Agreement 2/