PRIMED Consortium
@prsmethods.bsky.social
The NIH-funded Polygenic Risk Methods Development (PRIMED) Consortium. primedconsortium.org
Pinned
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
The call for #DNADay26 essays is out! Open to students in grades 9-12 📝 🧬
Pro tip for genetics professionals: the contest is also often looking for judges...
Pro tip for genetics professionals: the contest is also often looking for judges...
The #DNADay26 Essay Contest is HERE! 🧬This year’s challenge: Analyze a genetic treatment or therapy developed or widely used in recent years. Teachers—help your students share their ideas with the world! Submit by March 4 👉 https://www.ashg.org/dna-day/ #ASHG
January 12, 2026 at 7:00 PM
The call for #DNADay26 essays is out! Open to students in grades 9-12 📝 🧬
Pro tip for genetics professionals: the contest is also often looking for judges...
Pro tip for genetics professionals: the contest is also often looking for judges...
Follow us for more highlights throughout the year and see our running lists of publications and research highlights
primedconsortium.org/publications...
primedconsortium.org/research/hig...
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primedconsortium.org/publications...
primedconsortium.org/research/hig...
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View Publications | PRIMED Consortium
primedconsortium.org
January 9, 2026 at 1:06 AM
Follow us for more highlights throughout the year and see our running lists of publications and research highlights
primedconsortium.org/publications...
primedconsortium.org/research/hig...
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primedconsortium.org/publications...
primedconsortium.org/research/hig...
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November also saw the first data release of genetic and phenotypic data from the OurHealth study, with blended genome-exome sequencing funded by PRIMED,
primedconsortium.org/research/our... 8/
primedconsortium.org/research/our... 8/
OurHealth study | PRIMED Consortium
primedconsortium.org
January 9, 2026 at 1:06 AM
November also saw the first data release of genetic and phenotypic data from the OurHealth study, with blended genome-exome sequencing funded by PRIMED,
primedconsortium.org/research/our... 8/
primedconsortium.org/research/our... 8/
Recommendations for the responsible use of population descriptors in polygenic risk development were published in November
pubmed.ncbi.nlm.nih.gov/41286102 7/
pubmed.ncbi.nlm.nih.gov/41286102 7/
January 9, 2026 at 1:06 AM
Recommendations for the responsible use of population descriptors in polygenic risk development were published in November
pubmed.ncbi.nlm.nih.gov/41286102 7/
pubmed.ncbi.nlm.nih.gov/41286102 7/
At #ASHG25, a range of PRIMED work was presented in talks and posters
docs.google.com/spreadsheets... 6/
docs.google.com/spreadsheets... 6/
ASHG 2025 PRIMED Abstracts
docs.google.com
January 9, 2026 at 1:06 AM
At #ASHG25, a range of PRIMED work was presented in talks and posters
docs.google.com/spreadsheets... 6/
docs.google.com/spreadsheets... 6/
PRIMED members investigated incorporating social determinants of health into disease prediction in the NIH All of Us Research Program
doi.org/10.1101/2025... 5/
doi.org/10.1101/2025... 5/
January 9, 2026 at 1:06 AM
PRIMED members investigated incorporating social determinants of health into disease prediction in the NIH All of Us Research Program
doi.org/10.1101/2025... 5/
doi.org/10.1101/2025... 5/
The Data Sharing Working Group published a review of PRIMED consortium data sharing procedures and policy recommendations for future initiatives
pubmed.ncbi.nlm.nih.gov/40628271 4/
pubmed.ncbi.nlm.nih.gov/40628271 4/
January 9, 2026 at 1:06 AM
The Data Sharing Working Group published a review of PRIMED consortium data sharing procedures and policy recommendations for future initiatives
pubmed.ncbi.nlm.nih.gov/40628271 4/
pubmed.ncbi.nlm.nih.gov/40628271 4/
The Population Descriptors, Social and Ethical Implications Working Group published a new data model that allows flexible and responsible use of population descriptors, and aligns with @nationalacademies.org recommendations
pubmed.ncbi.nlm.nih.gov/40513563 3/
pubmed.ncbi.nlm.nih.gov/40513563 3/
January 9, 2026 at 1:06 AM
The Population Descriptors, Social and Ethical Implications Working Group published a new data model that allows flexible and responsible use of population descriptors, and aligns with @nationalacademies.org recommendations
pubmed.ncbi.nlm.nih.gov/40513563 3/
pubmed.ncbi.nlm.nih.gov/40513563 3/
We joined Bluesky! Here’s our PRIMED investigator starter pack - bsky.app/starter-pack... 2/
January 9, 2026 at 1:06 AM
We joined Bluesky! Here’s our PRIMED investigator starter pack - bsky.app/starter-pack... 2/
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
January 9, 2026 at 1:06 AM
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
Funding for BGE sequencing and analyses are provided through the NIH-funded PRIMED Consortium @prsmethods.bsky.social
For more information and how to apply for access, visit primedconsortium.org/research/our...
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For more information and how to apply for access, visit primedconsortium.org/research/our...
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OurHealth study | PRIMED Consortium
primedconsortium.org
December 3, 2025 at 8:41 PM
Funding for BGE sequencing and analyses are provided through the NIH-funded PRIMED Consortium @prsmethods.bsky.social
For more information and how to apply for access, visit primedconsortium.org/research/our...
/end
For more information and how to apply for access, visit primedconsortium.org/research/our...
/end
The release includes self-reported basic demographics, anthropometric traits, cardiometabolic outcomes, and Blended Genome-Exome sequencing data on 621 study participants
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December 3, 2025 at 8:41 PM
The release includes self-reported basic demographics, anthropometric traits, cardiometabolic outcomes, and Blended Genome-Exome sequencing data on 621 study participants
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2/
🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org!
anvilproject.org/news/2025/11...
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anvilproject.org/news/2025/11...
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Release of The OurHealth Study on the AnVIL Platform - AnVIL Portal
anvilproject.org
December 3, 2025 at 8:41 PM
🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org!
anvilproject.org/news/2025/11...
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anvilproject.org/news/2025/11...
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📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun
www.nature.com/articles/s41...
in @natgenet.nature.com
www.nature.com/articles/s41...
in @natgenet.nature.com
Recommendations for responsible use of population descriptors in polygenic risk score development - Nature Genetics
In this Perspective, authors from the Polygenic Risk Methods Development (PRIMED) Consortium highlight the ethical and analytical impact of population descriptors in polygenic risk score development a...
www.nature.com
December 2, 2025 at 2:39 AM
📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun
www.nature.com/articles/s41...
in @natgenet.nature.com
www.nature.com/articles/s41...
in @natgenet.nature.com
🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social !
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
@ajhgnews.bsky.social sat with Julie-Alexia Dias, MSc, in the latest "Inside AJHG" to discuss her recently published paper, “Evaluating multi-ancestry genome-wide association methods: statistical power, population structure, and practical implications.”➡️ ashg.org/ajhg/inside-... #ASHG #humangenetics
November 7, 2025 at 12:49 AM
🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social !
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...
Quantifying Social Determinants of Health for Disease Prediction: A Multi-Level Approach Using Healthy People 2030 and All of Us Data
Despite the growing recognition that social determinants of health (SDoH) play a prominent role in shaping health outcomes, inconsistent measures across health systems and research studies - and the a...
www.medrxiv.org
October 29, 2025 at 10:15 PM
👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...
Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...
ASHG 2025 PRIMED Abstracts
docs.google.com
October 14, 2025 at 4:14 PM
Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...
👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care
New online! Clinical use of polygenic risk scores: current status, barriers and future directions
Clinical use of polygenic risk scores: current status, barriers and future directions
Nature Reviews Genetics, Published online: 10 October 2025; doi:10.1038/s41576-025-00900-8This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.
www.nature.com
October 10, 2025 at 6:00 PM
👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care
Reposted by PRIMED Consortium
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!
August 25, 2025 at 6:55 PM
The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!
👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Sharing a global effort to develop PRSs for T2D in multiple ancestries. www.medrxiv.org/content/10.1... funded by NHGRI @prsdiversity.bsky.social #D_PRISM
Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim
Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermin...
www.medrxiv.org
August 15, 2025 at 6:02 PM
👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference
In-person registration closes Aug 19: https:/bit.ly/anvil2025
In-person registration closes Aug 19: https:/bit.ly/anvil2025
⏳ Only 1 Week Left to Register for ACC2025! Register before August 19 to come to Nashville on Sep 3–5! bit.ly/anvil2025
🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free
And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...
🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free
And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...
AnVIL Community Conference 2025: Abstract Submission Form
Please use this form to submit an abstract (300 word limit) to the AnVIL Community Conference 2025 in Nashville, TN. The conference will take place from September 3-5, 2025. In-person attendance is…
bit.ly
August 14, 2025 at 8:46 PM
📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference
In-person registration closes Aug 19: https:/bit.ly/anvil2025
In-person registration closes Aug 19: https:/bit.ly/anvil2025
Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
August 1, 2025 at 11:47 PM
Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
Reposted by PRIMED Consortium
🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
July 10, 2025 at 8:28 PM
🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
Co-authors include @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the Data Sharing Working Group!
@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium
@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium
July 10, 2025 at 11:46 PM
Co-authors include @johannalsmith.bsky.social, @quennawong.bsky.social, Whitney Hornsby, @mconomos.bsky.social, @blueyedgenes.bsky.social, and the Data Sharing Working Group!
@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium
@prsdiversity.bsky.social is an NHGRI and NCI funded Consortium