We don't do this regularly or anything, but every couple of years @cfbolz.bsky.social looks at how the PyPy binary sizes have developed. Looks like an ok balance between occasionally cleaning something up and thereby shrinking the binary; and then slow growth or explicit time/binary-size-tradeoffs.

Here's a screenshot of the Firefox Profiler UI showing VMProf output. The blue functions are native functions, yellow is Python functions and orange jitted functions (no example of that is in the screenshot).