Buccal PedBE and CheekAge are linked to self-reported morbidity and overall health, similarly to blood clocks. Notably, PedBE acceleration, which was developed in children, outperformed all other clocks when predicting chronic diseases (excluding cancer).

Very high correlations between buccal-derived clocks and chronological age have been observed among Germans of all ages. Their performances are comparable to blood clocks.

Buccal clocks vs Blood clocks - Do you get the same thing cuz it's easier to collect? Our new study in GeroScience shows similar performance of buccal and blood clocks in predicting health. But buccal clocks are less sensitive to SES. rdcu.be/eKJe8
#MPRGBiosocial @mpib-berlin.bsky.social

Key aspects of cellular senescence are measured: cell cycle arrest (CSP), macromolecular damage (SIP), and senescence-associated secretory phenotype - SASP (SRP). Overall measures include the average of the three pathways above and the expression level of SenMayo genes.

Senescence scores are associated with accelerated epigenetic aging, physiological dysregulation, multimorbidity, cognitive decline, and 6-year mortality. These associations persist after adjustment for epigenetic clocks.

Our new paper linking gene expression scores of cellular senescence and aging-related outcomes among older Americans is now available in Nature Communications
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