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QSPainRelief EU Project @qspainrelief.bsky.social · 5d

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability

🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado

#Neuroscience #Analgesics

Food addiction vulnerability in mice and humans and miRNA signatures

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

youtu.be/nIpZY5Msaec?...

YouTube video by Journal of Clinical Investigation

youtu.be

JCI - miRNA signatures associated with vulnerability to food addiction in mice and humans

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans

💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.

www.jci.org

Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function

💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.

AbstractGrowing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in hum

academic.oup.com

Frontiers | THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model

💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.

Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and thi...

doi.org

Role of CB2 cannabinoid receptor in the development of food addiction in male mice

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

2️⃣García-Blanco et al., 2023 www.sciencedirect.com/science/arti...
📖 #CB2 #CannabinoidReceptor & the development of food addiction in mice

💡CB2R is a modulatory node in the control of hedonic feeding and vulnerability to #FoodAddiction, making it a potential therapeutic target for eating disorders

The endocannabinoid system plays an important role in multiple behavioral responses due to its wide distribution in the central nervous system. The ca…

www.sciencedirect.com

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QSPainRelief EU Project @qspainrelief.bsky.social · 5d

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction

💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction

We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...

doi.org

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.

✅ Less pain
😵‍💫 Fewer side effects
☺️ Better QoL

✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:

🔗 doi.org/10.1021/acs....

🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR

👉 #morphine and #fentanyl elicit different activation patterns

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?

👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:

📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.

🔗 www.nature.com/articles/s41...

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.

🔗 doi.org/10.3390/ijms...

#allostery #pharmacology #receptors #ligands

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?

Find out👉: doi.org/10.1021/acso...

Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation

#GPCR

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about

👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE

🔗 doi.org/10.1016/j.dr...

#allostery #pharmacology #DrugDesign #GPCRs

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊

🔗 doi.org/10.1016/j.bc...

#Pharmacology #GPCRs

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🔦 Spotlight on link.springer.com/article/10.1...

🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs

✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential

#TranslationalPharmacology #DrugDevelopment

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...

🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.

💡This might also explain some inter-individual differences!

🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids

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Reposted by QSPainRelief EU Project

Juvenile Arthritis Research @jarproject.bsky.social · Jun 14

We have exceptional treatments for RMDs but that doesn't always mean the chronic pain is treated. We need to be open to pain specialists. Patients need to keep advocating for themselves when still in pain despite their RMD appearing under control. Nadia Malliou at #eular2025 @eular.org

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QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.

Potential impact:

👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability

🔗 www.page-meeting.org/default.asp?...

#ChronicPain #Pain

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

📖 Just published 💊

👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏

🔗 www.sciencedirect.com/science/arti...

#Pharmacology #ComputationalBiology

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions.

🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain

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QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear.

👉 Social support is crucial, but HOW matters

🔗 doi.org/10.1371/jour...

#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social

QSPainRelief EU Project @qspainrelief.bsky.social · 8d

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...

👉Best algorithm: Random Forest

💡Great for #CNS drug discovery!

#BBB #PBPK #ML

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QSPainRelief EU Project @qspainrelief.bsky.social · 8d

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?

🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.

#BBB #DrugInteractions #morphine #modelling #brain

🔗 link.springer.com/article/10.1...

QSPainRelief EU Project @qspainrelief.bsky.social · 10d

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025)

👉 onlinelibrary.wiley.com/doi/10.1002/...

⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later.

#PainPrediction