The small lipoprotein LptM intercalates the LptD lateral gate promoting gate dynamics and access by LPS. LptY (YedD) stabilizes the beta-taco domain and contributes together with LptM to optimal functioning of the Lpt transenvelope bridge.

The LptD beta-strand 1, defining the mobile side of the lateral gate, binds LPS and performs a stroke movement toward the external leaflet during the contracted-to-extended state transition.

In this paper we show that LptD functions via a conformational switch of the beta-taco/beta-barrel interface, which alternates between contracted and extended states.

Here our new preprint on the LPS holo-translocon doi.org/10.1101/2025... , collaboration with Yves Quentin @JulieMarcoux @fronzeslab.bsky.social @pstansfeld.bsky.social - @cbitoulouse.bsky.social

Spoiler of our new preprint: How does LPS cross the bacterial outer membrane?

emploi.cnrs.fr/Offres/CDD/U... QR code expired, use this link

Last days to send your application! deadline December 20!

Let's start the Bsky adventure with a job post. Still about two weeks to apply to this postdoc position on "Molecular and Structural Biology of Membrane Biogenesis" in the labs @raffaeleieva.bsky.social ky.social and @fronzeslab.bsky.social slab.bsky.social in beautiful south-west of France!