Raiees Andrabi
@raieesandrabi.bsky.social
Associate Professor @PennMedicine @Penn
Viruses| Vaccines| Protein engineering| B cells| Antibodies| Glycans. Cricket enthusiast
https://www.med.upenn.edu/apps/faculty/index.php/g275/p9737250
Viruses| Vaccines| Protein engineering| B cells| Antibodies| Glycans. Cricket enthusiast
https://www.med.upenn.edu/apps/faculty/index.php/g275/p9737250
In our new study, we show that several pre-Omicron RBD bnAbs still neutralize highly mutated SARS-CoV-2 variants. Structures reveal conserved, vaccine-targetable epitopes that resist extreme antigenic drift, highlighting promising targets for pan-sarbecovirus vaccines www.cell.com/cell-reports...
Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
Identifying and understanding the molecular basis of conserved spike epitopes targeted
by broadly neutralizing antibodies (bnAbs) are key for developing broad coronavirus
vaccine design. Song et al. r...
www.cell.com
July 9, 2025 at 7:09 PM
In our new study, we show that several pre-Omicron RBD bnAbs still neutralize highly mutated SARS-CoV-2 variants. Structures reveal conserved, vaccine-targetable epitopes that resist extreme antigenic drift, highlighting promising targets for pan-sarbecovirus vaccines www.cell.com/cell-reports...
A fantastic collaborative effort with the BatistaLab (Ragon/Harvard), ShawLab(Penn) and IrvineLab (Scripps) where we show how targeted immunogen design can induce HIV broadly neutralizing antibody responses! www.biorxiv.org/content/10.1...
Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization
Current vaccine strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multi-boost immunization regimens. In rhesus macaques, SHIV infection has been obs...
www.biorxiv.org
June 26, 2025 at 2:36 PM
A fantastic collaborative effort with the BatistaLab (Ragon/Harvard), ShawLab(Penn) and IrvineLab (Scripps) where we show how targeted immunogen design can induce HIV broadly neutralizing antibody responses! www.biorxiv.org/content/10.1...