@rboussageon.bsky.social
Reposted
No names, unfortunately 😉
bmjopen.bmj.com/content/15/1...
bmjopen.bmj.com/content/15/1...
Undisclosed financial conflicts of interest among physician-authors in leading US psychiatry journals: a cross-sectional study
Objective To assess the prevalence and magnitude of undisclosed financial conflicts of interest (COIs) among physician-authors in high-impact US-based psychiatry journals.
Design Cross-sectional stud...
bmjopen.bmj.com
November 21, 2025 at 3:34 PM
No names, unfortunately 😉
bmjopen.bmj.com/content/15/1...
bmjopen.bmj.com/content/15/1...
Reposted
Reposted
🆕 UBC TI Therapeutics Letter 159 🆕
Escitalopram vs citalopram
www.ti.ubc.ca/letter159
✅ Citalopram best choice for most new prescriptions
✅ Citalopram costs less + works just as well
#BetterPrescribing #prescribing #MedEd #antidepressants
Escitalopram vs citalopram
www.ti.ubc.ca/letter159
✅ Citalopram best choice for most new prescriptions
✅ Citalopram costs less + works just as well
#BetterPrescribing #prescribing #MedEd #antidepressants
November 13, 2025 at 10:29 PM
🆕 UBC TI Therapeutics Letter 159 🆕
Escitalopram vs citalopram
www.ti.ubc.ca/letter159
✅ Citalopram best choice for most new prescriptions
✅ Citalopram costs less + works just as well
#BetterPrescribing #prescribing #MedEd #antidepressants
Escitalopram vs citalopram
www.ti.ubc.ca/letter159
✅ Citalopram best choice for most new prescriptions
✅ Citalopram costs less + works just as well
#BetterPrescribing #prescribing #MedEd #antidepressants
Reposted
Bon usage du médicament
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
#Recommandations #Antibiotiques #SoinsPrimaires
www.em-consulte.com/article/1773...
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
#Recommandations #Antibiotiques #SoinsPrimaires
www.em-consulte.com/article/1773...
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
www.em-consulte.com
November 7, 2025 at 7:44 AM
Bon usage du médicament
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
#Recommandations #Antibiotiques #SoinsPrimaires
www.em-consulte.com/article/1773...
Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires
#Recommandations #Antibiotiques #SoinsPrimaires
www.em-consulte.com/article/1773...
Voilà un raisonnement fondé sur les preuves....et une perspective de médecine générale !
Bravo!
www.cfp.ca/content/71/1...
Bravo!
www.cfp.ca/content/71/1...
Clinical prudence urged in testing for steatotic liver disease
We read with interest “[Approach to steatotic liver disease in the office. Diagnosis, management, and proposed nomenclature][1]” by Szilagyi and Hilzenrat in the April 2025 issue of Canadian Family Ph...
www.cfp.ca
October 19, 2025 at 10:13 AM
Voilà un raisonnement fondé sur les preuves....et une perspective de médecine générale !
Bravo!
www.cfp.ca/content/71/1...
Bravo!
www.cfp.ca/content/71/1...
Reposted
"About 67% of all antidepressant and antipsychotic treatment episodes in the 700 included patients (mean age = 14.6 years, girls = 67%) were off-label."
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial - Child and Adolescent Psychiatry and Mental Health
Background/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors. This study aimed to assess freque...
link.springer.com
October 16, 2025 at 7:56 AM
"About 67% of all antidepressant and antipsychotic treatment episodes in the 700 included patients (mean age = 14.6 years, girls = 67%) were off-label."
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted
opportunity costs associated with NICE recommendations.
Defo the most important h economics paper you will read today, maybe this week, maybe the year so far
This is where the primary care budget gets spent
A
www.thelancet.com/journals/lan...
Defo the most important h economics paper you will read today, maybe this week, maybe the year so far
This is where the primary care budget gets spent
A
www.thelancet.com/journals/lan...
December 13, 2024 at 6:30 PM
opportunity costs associated with NICE recommendations.
Defo the most important h economics paper you will read today, maybe this week, maybe the year so far
This is where the primary care budget gets spent
A
www.thelancet.com/journals/lan...
Defo the most important h economics paper you will read today, maybe this week, maybe the year so far
This is where the primary care budget gets spent
A
www.thelancet.com/journals/lan...
Reposted
17/ Therefore, we dug deeper into the two Lancet NMAs and we indeed could explain the discrepancy after isolating a potential zombie trial. But more later, when this will be published, and we experienced the 4th rejection already (preprint here www.medrxiv.org/content/10.1...)
A Re-Appraisal of Three Network Meta-Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents
Objective To explain discrepant findings for fluoxetine’s efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recommend...
www.medrxiv.org
September 26, 2025 at 5:00 AM
17/ Therefore, we dug deeper into the two Lancet NMAs and we indeed could explain the discrepancy after isolating a potential zombie trial. But more later, when this will be published, and we experienced the 4th rejection already (preprint here www.medrxiv.org/content/10.1...)
Reposted
1/32 Fluoxetine's loss of efficacy for the treatment of pediatric depression.
🚨 New paper and pre-print alert 🚨
With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef
A longer 🧵
🚨 New paper and pre-print alert 🚨
With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef
A longer 🧵
September 26, 2025 at 5:00 AM
1/32 Fluoxetine's loss of efficacy for the treatment of pediatric depression.
🚨 New paper and pre-print alert 🚨
With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef
A longer 🧵
🚨 New paper and pre-print alert 🚨
With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef
A longer 🧵
Reposted
another TI @drug-evidence.bsky.social + collaborators publication:
It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge!
(DM me to ask how I know!)
qualitysafety.bmj.com/content/qhc/...
#choosingwisely #overtesting
It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge!
(DM me to ask how I know!)
qualitysafety.bmj.com/content/qhc/...
#choosingwisely #overtesting
October 7, 2025 at 12:07 AM
another TI @drug-evidence.bsky.social + collaborators publication:
It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge!
(DM me to ask how I know!)
qualitysafety.bmj.com/content/qhc/...
#choosingwisely #overtesting
It is possible to reduce the unnecessary over-use of TSH and related #thyroid tests!!! But it can be a challenge!
(DM me to ask how I know!)
qualitysafety.bmj.com/content/qhc/...
#choosingwisely #overtesting
Reposted
🚨 ICYMI: UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update
👉 ti.ubc.ca/letter156
Antidepressants can be helpful for some people; but starting or
stopping requires care
Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
👉 ti.ubc.ca/letter156
Antidepressants can be helpful for some people; but starting or
stopping requires care
Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
October 1, 2025 at 11:11 PM
🚨 ICYMI: UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update
👉 ti.ubc.ca/letter156
Antidepressants can be helpful for some people; but starting or
stopping requires care
Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
👉 ti.ubc.ca/letter156
Antidepressants can be helpful for some people; but starting or
stopping requires care
Knowing about types of possible withdrawal problems helps prescribers guide patients in 🛑 more safely
Reposted
In this blog, I take a closer look at how leading psychiatrists responded to MAHA's critical views on psychiatric drugs for children and adolescents.
Spoiler: they could have done MUCH better.
ploederlm.github.io/blogs/MAHA-r...
Spoiler: they could have done MUCH better.
ploederlm.github.io/blogs/MAHA-r...
Martin Plöderl - A call for evidence based, fear-free practice
ploederlm.github.io
October 2, 2025 at 6:11 PM
In this blog, I take a closer look at how leading psychiatrists responded to MAHA's critical views on psychiatric drugs for children and adolescents.
Spoiler: they could have done MUCH better.
ploederlm.github.io/blogs/MAHA-r...
Spoiler: they could have done MUCH better.
ploederlm.github.io/blogs/MAHA-r...
Reposted
This is such important work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
The aim of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project is to develop a tool to identify problematic RCTs …
www.sciencedirect.com
August 21, 2025 at 10:47 AM
This is such important work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
Interesting. Discontinuation symptoms are not so bit with antidepressants (SMD=0.3). However, 0.3 is the SMD of antidepressant efficacy in MDD... It means that we must also agree to say that antidepressants efficacy is not so big either. And GRADE is likely better for the 2nd claim than the 1st one.
Incidence and Nature of Antidepressant Discontinuation Symptoms
This systematic review and meta-analysis examines the presence and incidence of discontinuation symptoms in individuals who stop taking antidepressants.
jamanetwork.com
July 10, 2025 at 6:51 AM
Interesting. Discontinuation symptoms are not so bit with antidepressants (SMD=0.3). However, 0.3 is the SMD of antidepressant efficacy in MDD... It means that we must also agree to say that antidepressants efficacy is not so big either. And GRADE is likely better for the 2nd claim than the 1st one.
Reposted
One more thought: while a statistically significant average diff of 1.8 points on the Hamilton Scale (range 0-52) in similar short-term RCTs is used for justificatin of AD prescriptions, the increase of 1-2 pts on the withdrawal (DESS) scale (range 0-43) seems unimportant. SMD ca. 0.3 for both.
July 12, 2025 at 8:04 AM
One more thought: while a statistically significant average diff of 1.8 points on the Hamilton Scale (range 0-52) in similar short-term RCTs is used for justificatin of AD prescriptions, the increase of 1-2 pts on the withdrawal (DESS) scale (range 0-43) seems unimportant. SMD ca. 0.3 for both.
On en parle...
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
« Réévaluer des médicaments remboursés à 15 % ou à 30 % est une nécessité en période de restrictions budgétaires »
TRIBUNE. La prescription de produits pharmaceutiques n’ayant pas démontré leur efficacité clinique pose des problèmes éthiques, écologiques et économiques, explique, dans une tribune au « Monde », Rém...
www.lemonde.fr
July 5, 2025 at 9:06 PM
On en parle...
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
Reposted
#DragiWebdo n°491 : Violences (USPSTF), nutrition femme/enfant (NICE), vaccin zona (CNGE), SCA sujet âgé, diabète de type 2 (dépistages, déprescription, cagrilintide)
www.medicalement-geek.com/2025/06/drag...
www.medicalement-geek.com/2025/06/drag...
Dragi Webdo n°491 : Violences (USPSTF), nutrition femme/enfant (NICE), vaccin zona (CNGE), SCA sujet âgé, diabète de type 2 (dépistages, déprescription, cagrilintide)
Dragi Webdo n°491 : Violences (USPSTF), nutrition femme/enfant (NICE), vaccin zona (CNGE), SCA sujet âgé, diabète de type 2, cagrilintide
www.medicalement-geek.com
June 30, 2025 at 8:05 PM
#DragiWebdo n°491 : Violences (USPSTF), nutrition femme/enfant (NICE), vaccin zona (CNGE), SCA sujet âgé, diabète de type 2 (dépistages, déprescription, cagrilintide)
www.medicalement-geek.com/2025/06/drag...
www.medicalement-geek.com/2025/06/drag...
Reposted
🧵1/ Today we’re sharing an important article we co-authored with François Gonon, Henry Gouraud, André Gillibert, Bruno Falissard, Lisa Cosgrove, Kasper Kepp & Ioana Cristea.
It’s about how selective use of science can distort policymaking—even in public health.
It’s about how selective use of science can distort policymaking—even in public health.
Advocacy by nonprofit scientific institutions needs to be evidence-based: a case study
Scientific institutions, including universities and research centers, occasionally engage in advocacy to gain financial support. However, this can be …
www.sciencedirect.com
June 3, 2025 at 5:42 AM
🧵1/ Today we’re sharing an important article we co-authored with François Gonon, Henry Gouraud, André Gillibert, Bruno Falissard, Lisa Cosgrove, Kasper Kepp & Ioana Cristea.
It’s about how selective use of science can distort policymaking—even in public health.
It’s about how selective use of science can distort policymaking—even in public health.
Reposted
Amazing - RCT found exercise reduced risk of death (37%) and recurrent or new colon cancers (28%). “Mostly stage 3 colon cancer … randomly assigned to take part in a structured exercise programme (445) or to just receive a healthy lifestyle booklet (444).” www.theguardian.com/society/2025...
Exercise ‘better than drugs’ to stop cancer returning after treatment, trial finds
First clear evidence that structured exercise regime reduces risk of dying by a third, can stop tumours coming back or a new cancer developing
www.theguardian.com
June 1, 2025 at 7:23 PM
Amazing - RCT found exercise reduced risk of death (37%) and recurrent or new colon cancers (28%). “Mostly stage 3 colon cancer … randomly assigned to take part in a structured exercise programme (445) or to just receive a healthy lifestyle booklet (444).” www.theguardian.com/society/2025...