remeseiro-lab.bsky.social
Silvia Remeseiro Lab
@remeseiro-lab.bsky.social
320 followers 730 following 26 posts
Associate Professor & Docent @umeauniversitet.bsky.social Wallenberg Fellow in Molecular Medicine at WCMM Umeå Postdoc @embl.org PhD @cniostopcancer.bsky.social 3D genomics , epigenomics, gene regulation, enhancer, cancer, glioblastoma, cancer neuroscience
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pietraslab.bsky.social
Alexander Pietras Lab @pietraslab.bsky.social · 20d
Thanks to all speakers, including bsky users @winklerlab.bsky.social @claudiakleinman.bsky.social @nelander-lab.bsky.social @gocastelobranco.bsky.social, the Ragnar Söderberg foundation, and co-hosts @remeseiro-lab.bsky.social, @maawim.bsky.social, and Fredrik Swartling.
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Reposted by Silvia Remeseiro Lab
umeauniversitet.bsky.social
Umeå University @umeauniversitet.bsky.social · Sep 3
Emmanuelle Charpentier has been appointed honorary citizen of Umeå Municipality, and in connection with the honorary citizenship ceremony, the Nobel Prize winner is making a long-awaited visit to her alma mater for a public seminar/talk. Read more here: www.umu.se/en/events/se...
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Reposted by Silvia Remeseiro Lab
radaiglesiaslab.bsky.social
Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Aug 13
#Preprint alert! 📣

We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements

www.biorxiv.org/cgi/content/...
MLL2 facilitates long-range gene regulation through LINE1 elements
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...
www.biorxiv.org
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Reposted by Silvia Remeseiro Lab
remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · Aug 1
Read here our 'Ideas & Speculations' now out @wiley.com #BioEssays on how #neuron–glioma #interactions begin to be
decoded through the #epigenetic lens.
#GBM #glioma #CancerNeuroscience

onlinelibrary.wiley.com/doi/10.1002/...
What Epigenetics Teaches Us About Neuron–Glioma Interactions
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense ....
onlinelibrary.wiley.com
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · Aug 1
Read here our 'Ideas & Speculations' now out @wiley.com #BioEssays on how #neuron–glioma #interactions begin to be
decoded through the #epigenetic lens.
#GBM #glioma #CancerNeuroscience

onlinelibrary.wiley.com/doi/10.1002/...
What Epigenetics Teaches Us About Neuron–Glioma Interactions
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense ....
onlinelibrary.wiley.com
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · Aug 1
Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab.

About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.

genome.cshlp.org/content/earl...
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Reposted by Silvia Remeseiro Lab
kawresearch.bsky.social
Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · Jun 4
The latest upgrading of the #supercomputer Berzelius @liu.se has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as materials science, bioinformatics and machine learning #research #science
tinyurl.com/ydduwzc7
Stronger Berzelius ready for the research of the future
The latest upgrading of the supercomputer Berzelius at LiU has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as mater...
tinyurl.com
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Reposted by Silvia Remeseiro Lab
kawresearch.bsky.social
Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · Jun 4
Nu är den senaste uppgraderingen av superdatorn Berzelius @liu.se klar. Med en fördubblad kapacitet kan forskare i hela Sverige ta sig an samtidens och framtidens utmaningar inom bland annat materialvetenskap, bioinformatik och maskininlärning #forskning #vetenskap
tinyurl.com/nns7pks6
Starkare Berzelius är redo för framtidens forskning
Nu är den senaste uppgraderingen av superdatorn Berzelius vid LiU klar. Med en fördubblad kapacitet kan forskare i hela Sverige ta sig an samtidens och framtidens utmaningar inom bland annat materialv...
tinyurl.com
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Reposted by Silvia Remeseiro Lab
stefanschoenfelder.bsky.social
Stefan Schoenfelder @stefanschoenfelder.bsky.social · Jun 4
Really looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series.

📅 June 5th 2025 tomorrow
⏰ 4pm GMT

Please join us:
us02web.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: The 3D Regulatory Genome: Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches. After registering, you will rec...
Join our guest speaker, Dr. Alvaro Rada-Iglesias, in this exciting seminar on the 3D Regulatory Genome, sponsored by Enhanced Genomics.
us02web.zoom.us
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · Jun 2
High-grade gliomas integrate into neural circuits in the human brain affecting cognition, language and decreasing survival. Fascinating field!
See you at #PALS2025
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 29
Are you a US-based researcher who want to return to #Sweden 🇸🇪 to establish your #research here?

This is your shot to make it happen 👇
strategiska.se/en/press-rel...
45 million in research support for returnees from USA!
strategiska.se
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Reposted by Silvia Remeseiro Lab
danielibrahim.bsky.social
Daniel Ibrahim @danielibrahim.bsky.social · May 27
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
Work funded by @kawresearch.bsky.social @vetenskapsradet.bsky.social #Cancerfonden #StratNeuro #Kempestiftelsen #CancerforskningsfondenNorrland

📍 @umeauniversitet.bsky.social #WCMM_Umeå

Collab with #CemalErdem @kirkebylab.bsky.social @hornblad-lab.bsky.social
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
With these studies we have showed that #epigenetic regulators of the #neuron-to-glioma axis can serve as actionable #targets in #GB.

Viewing neuron-glioma interactions through an epigenetic lens helped us understand how glioma cells exploit neural signals to fuel their growth.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
#ARX, #GSX2 and members of the #DLX family were identified as key #TFs regulating #GABAergic related networks in #GB.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
AMPAR antagonist NBQX reduces GB cell proliferation in co-culture with glutamatergic neurons, as expected. But the GABAAR antagonist picrotoxin doesn’t affect GB growth in the setting with GABAergic interneurons. This suggests #GABA signalling drives #GB growth through non-synaptic mechanisms.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
#GABAergic neuron-to-glioma synapses were recently found in #DMG/#DIPG, but not #GB @michellemonje.bsky.social @tarabarron.bsky.social

Yet our ML-based analysis flagged #GABA signalling as key in #GB. Notably, we showed that #GABAergic neurons promote #GB cell proliferation in co-culture assays.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
#glutamatergic neuron-to-glioma synapses were found in #glioblastoma — key findings from @winklerlab.bsky.social @michellemonje.bsky.social
We showed the SMAD3-PITX1 GRN drives this crosstalk. SMAD3 inhibition + neural activity boosts #GB growth in co-culture with glutamatergic neurons and in vivo.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
Among the new #GRNs that we identified, #GABA signalling emerges as a previously unrecognised player in #glioblastoma.
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
Now we applied #MOBILE, a #ML based method, to integrate #multiomics data from #GB and uncovered new #GRNs and #TFs relevant for #glioblastoma pathogenesis.

📝 doi.org/10.1101/2025...
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
Over a year ago in @natcomms.nature.com we showed how rewiring of #enhancer landscape & #3Dgenome underlies #neuron-to-glioma synaptic communication in #GB. SMAD3 & PITX1 emerged as key #TF and targeting them alters tumour growth.
doi.org/10.1038/s414...
Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication - Nature Communications
The integration of transcriptomics and epigenomics data helps to better understand the regulatory and topological changes in glioblastoma subtypes. Here, the authors map the promoter-enhancer interact...
doi.org
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 21
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM

📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
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Reposted by Silvia Remeseiro Lab
pietraslab.bsky.social
Alexander Pietras Lab @pietraslab.bsky.social · May 15
🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...
Doctoral Student in Tumor Biology
Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo
lu.varbi.com
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 15
Spetses Summer School on Functional Genomics of Metabolic Diseases

functionalgenomics2025.febsevents.org
FEBS Advanced Lecture Course 2025 – Functional genomics of metabolic diseases<br />
August 29 – September 3, 2025 │ Spetses Island, Greece
functionalgenomics2025.febsevents.org
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remeseiro-lab.bsky.social
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 13
Link to register here 👇
www.kva.se/evenemang/br...
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