Luke Lavis
@rhodamine110.bsky.social
1.1K followers 96 following 29 posts
Chemist at HHMI's Janelia Research Campus. Passionate about designing, building, and giving away fluorescent dyes to illuminate biological systems. Striving to be positive about all things chemistry (except ChemDraw). ORCID: 0000-0002-0789-6343
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rhodamine110.bsky.social
PSA: If you are a #ChemDraw user on the Mac, they changed the font for the ACS Document 1996 style in the recent past; Helvetica to Arial. Watch out for vestigial Helvetica characters in figures, which some journal submission platforms *really* don't like.
a rainbow and a star with the words " make you know " on it
ALT: a rainbow and a star with the words " make you know " on it
media.tenor.com
Reposted by Luke Lavis
tsaiwenchen.bsky.social
My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇

www.nature.com/articles/s41...

Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
Reposted by Luke Lavis
faseborg.bsky.social
The sophomore outing for this revelatory conference is here! Join us for #OPTSRC for the latest in optical probes, which are crucial for biological imaging techniques. You'll meet organizers like @rhodamine110.bsky.social and more. View the agenda and save your space: buff.ly/LIRRF15
rhodamine110.bsky.social
We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N
Research Technician - Open Chemistry
Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...
bit.ly
rhodamine110.bsky.social
Just to be clear—I was a lowly tech at Probes making large amounts the dyes that others had dreamt up. But I loved the chemistry and the colors—it inspired me to dream up my own fluorophores.
Reposted by Luke Lavis
samuelconnell.3i.social
Thanks Luke! Grateful for your good work kind sir. Thirty years ago, I remember crowding around the lightbox in awe with my Pharmingen R&D colleagues at the glowing BioColors vectors we had grown up after licensing from Roger Tsien's Lab down the street at UCSD where I was about to graduate. 🔬🧪🥽🔥🌈
a picture of luke skywalker with the words luke !!! above him
ALT: a picture of luke skywalker with the words luke !!! above him
media.tenor.com
rhodamine110.bsky.social
I’ve been a dye chemist for a quarter century! 25 years ago today I walked into this funky little company in Eugene, OR called Molecular Probes. My first task was making Alexa Fluor 633 and I never looked back. I am grateful for all my teachers and mentors along the way.
Reposted by Luke Lavis
hhmijanelia.bsky.social
🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠

🔗 www.janelia.org/news/new-ima...
rhodamine110.bsky.social
A little nugget of whimsy: Apple Music has these “lyrics” for the Star Wars main theme (from ESB).
rhodamine110.bsky.social
You know you're getting old when your Organic Chemistry Lab TA training partner from the first week of grad school is now an editor at @acs.org (does this mean I have to click 'Accept' @pomerantz.bsky.social?)
rhodamine110.bsky.social
How it started: About eight years ago Bob Tjian ("Tij") and I sat in the back of cab in San Francisco and discussed the crazy idea of using live-cell single-molecule tracking for high-throughput drug screening.

How it's going:
rhodamine110.bsky.social
What would be a good aliquot size?
rhodamine110.bsky.social
And yeah, Hoechst is cheap but we could have it as part of a pack or even a single vial with a mix of dyes.
rhodamine110.bsky.social
Just checking that “green” is 488 nm excitation and “deep red” is 640 nm excitation. Maybe with a few 560 nm excited dyes too.
rhodamine110.bsky.social
That is a great suggestion. Could we do a simple set like ERTracker Green, MitoTracker Orange, and Hoechst 33342? Anything else colorwise?
rhodamine110.bsky.social
Hey #chemsky and beyond, with all that is going on, I am curious what expensive, high margin molecules we could provide to the community for free. What things do you use all the time, cost way too much, and would make a difference? Alexa Fluor 488 NHS? Other dyes? Other molecule?
rhodamine110.bsky.social
Thank you Jörg! This means a ton coming from a giant in the field.
rhodamine110.bsky.social
Thanks Mike. We all need a little something positive these days.
rhodamine110.bsky.social
Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...
Stars by the Pocketful
SWIR dyes─The Eras Tour. This love story between chemistry and biology shines.
pubs.acs.org
rhodamine110.bsky.social
Our multifunctional ligands to BRD4 and histone H3.3:
rhodamine110.bsky.social
Is that yield the synthetic yield or the quantum yield?
rhodamine110.bsky.social
I love that sodium borate resulted in the protection of some of the most beautiful coastline on the planet. en.wikipedia.org/wiki/Samuel_...