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RNA Society Journal @rnajournal.bsky.social · 5d

HPV E6 exploits codon usage to reduce antigen presentation and evade immunity; combinations of synonymous substitutions restore E6 expression and T cell activation bit.ly/3VUKzvo

RNA Society Journal @rnajournal.bsky.social · 5d

HRV-B3 IRES acts as a position-dependent negative regulator of RNA abundance from the upstream promoter. We found that this effect can be mitigated by inserting a spacer between IRES and the promoter bit.ly/4nEhYGA

RNA Society Journal @rnajournal.bsky.social · 8d

Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery bit.ly/4n38pB3

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RNA Society Journal @rnajournal.bsky.social · 9d

CSDE1 is present at low levels in healthy melanocytes, but upon transformation its expression rises and it becomes phosphorylated, promoting stronger interactions with ribosomes, possibly at membrane bit.ly/3JOdi2c

RNA Society Journal @rnajournal.bsky.social · 9d

RNA G-quadruplexes (rG4) are generally depleted among single-stranded RNA viruses. However, they can be pharmacologically induced by small molecule ligands. Synthetic rG4s disrupt viral transcription and reduce infectivity bit.ly/4pptqaX

Synthetically inducing G-quadruplexes in coronavirus genome reduces infectivity

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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RNA Society Journal @rnajournal.bsky.social · 13d

Therapeutic strategies for Fragile X Syndrome (FXS) aimed at CGG repeat contraction, demethylation of the FMR1 gene, and elimination of the FMR1-217 isoform to restore normal FMR1 expression and FMRP levels #FragileXSyndrome #RepeatEexpansion #SplicingDysregulation bit.ly/4fZOf6R

RNA Society Journal @rnajournal.bsky.social · 13d

Mitochondrial (mt-) tRNA modifications play pivotal roles in decoding and sustaining tRNA stability. Loss of mt-tRNA modifications can result in mitochondrial dysfunctions and diseases bit.ly/3E07Feq

RNA Society Journal @rnajournal.bsky.social · 15d

Our findings suggest that Rmd9 plays a critical role in yeast mitochondrial gene expression by regulating ribosomal biogenesis and mRNA stability bit.ly/3E3bLCu

RNA Society Journal @rnajournal.bsky.social · 16d

The application of UNA and LNA modifications allows for the manipulation of oligonucleotide hybridization preference, which in turn enhances the regulatory properties of SSOs and helps to verify the regulatory function of intron 9 bit.ly/40CEwPj

RNA Society Journal @rnajournal.bsky.social · 20d

Highly recurrent somatic mutations in the gene encoding the core splicing factor SF3B1 are drivers of multiple cancer types. We discuss how specific transcripts affected by aberrant splicing in SF3B1-mutant cells contribute to the initiation and progression of cancer bit.ly/4bqmRy2

RNA Society Journal @rnajournal.bsky.social · 20d

Discoveries of the SMN complex and its unanticipated function in RNP assembly, essential for spliceosomal snRNP biogenesis, advanced understanding of RNA biology and pathogenesis bit.ly/3Xv2hGX

RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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RNA Society Journal @rnajournal.bsky.social · 22d

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RNA Society Journal @rnajournal.bsky.social · 23d

Activated protein synthesis is a hallmark of cancer. Targeting eukaryotic translation initiation factor 4F (eIF4F) complex has been identified as a promising strategy for cancer treatment bit.ly/3F4Sv8g

RNA Society Journal @rnajournal.bsky.social · 26d

In this review, we describe the current state of knowledge on adenosine deamination type RNA editing, its involvement in disease development, and its potential as a therapeutic. Lastly, we highlight open challenges and questions that need to be addressed. bit.ly/3F3Vqy1

RNA Society Journal @rnajournal.bsky.social · 27d

TRAP1 moonlights as an RNA-binding protein, enhancing translation of the splicing factor LUC7L3 to drive proliferation in high-grade serous ovarian cancer cells. #TRAP1 #RBP #ovariancancer bit.ly/47t3apu

RNA Society Journal @rnajournal.bsky.social · 28d

Here, we discuss promising approaches employed to regulate NMD for therapeutic purposes and highlight potential challenges in future clinical development bit.ly/3F86Ron

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RNA Society Journal @rnajournal.bsky.social · 29d

This review discusses the distribution, regulation, and mechanisms of cytoplasmic polyadenylation element-binding proteins (CPEBs), highlighting their dual roles in either promoting or repressing gene expression depending on cellular context. bit.ly/41pFqhp

RNA Society Journal @rnajournal.bsky.social · Sep 8

A better understanding of how genetic variants contribute to the pathogenesis of cardiac diseases will necessitate exploration of how functions beyond splicing are impacted bit.ly/3DkHM9d

RNA Society Journal @rnajournal.bsky.social · Sep 2

OMA-1 is a zinc finger RNA-binding protein required for oocyte maturation. This work identifies an arginine-rich peptide upstream of the zinc finger required for both RNA binding and embryogenesis bit.ly/3JBkwXg

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RNA Society Journal @rnajournal.bsky.social · Aug 29

The absence of an inductive effect confers pseudouridine residues with resistance to enzyme-catalyzed and spontaneous strand cleavage bit.ly/4lF0dFP

RNA Society Journal @rnajournal.bsky.social · Aug 28

We present a method to profile RNA within membrane-less organelles, utilizing in situ transcription and linear amplification. We substantiate the accumulation of immature pre-mRNAs in stress granules bit.ly/4mALAEk

RNA Society Journal @rnajournal.bsky.social · Aug 28

PACT suppresses PKR activation, thus preventing activation of the integrated stress response, NF-κB, and cell death. Dimerization and double-stranded #RNA binding by PACT is required for this function. @kylecottrell.bsky.social @cancer-inst-purdue.bsky.social bit.ly/4oC3Vm7

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RNA Society Journal @rnajournal.bsky.social · Aug 27

Spatiotemporal NAIL-MS analysis shows that ALKBH5 does not affect global m6A turnover in human mRNA across subcellular compartments under standard growth conditions bit.ly/4lvVtC6

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RNA Society Journal @rnajournal.bsky.social · Aug 26

An internal 8U tract in a recoded influenza A virus segment causes viral polymerase slippage. This in turn leads to truncated protein production, interferon stimulation and reduced virus production bit.ly/4lr9hxX

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RNA Society Journal @rnajournal.bsky.social · Aug 25

Two-step VEGF HDB recognition by an aptamer, t44.27, was unveiled. Transient interaction was followed by a tight-complex formation and latter of which is essential to antagonize heparin binding bit.ly/4lb8Uap