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Scott Rothbart @rothbartlab.bsky.social · Jun 25

Congratulations, Wesley!!!

Reposted by Scott Rothbart

Van Andel Institute (VAI) @vai.org · Apr 21

A study led by VAI’s @rothbartlab.bsky.social and his team sheds light on how interwoven epigenetic layers work together to sustain cancer cell survival. Their findings reveal a potential weak spot that could be leveraged to improve treatment.

Pinpointing weaknesses in cancer’s armor – Van Andel Institute

Read about Pinpointing weaknesses in cancer’s armor on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

www.vai.org

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Reposted by Scott Rothbart

Anna Knörlein @annaknoer.bsky.social · Feb 14

Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!

🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy

A great opportunity to present your work, engage in discussions, and network with peers.

🔗 Register now!
Register here

2025 Histone and DNA Modifications (GRS) Seminar GRC

The 2025 Gordon Research Seminar on Histone and DNA Modifications (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

www.grc.org

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Scott Rothbart @rothbartlab.bsky.social · Feb 5

@vainstitute.bsky.social
Thanks for the add!

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Scott Rothbart @rothbartlab.bsky.social · Dec 15

Happy holidays from our lab family to you and yours!

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Scott Rothbart @rothbartlab.bsky.social · Dec 10

Short’s was Michigan’s best microbrewery even before this genius holiday marketing campaign! #bringmebacksomethingfrench

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Scott Rothbart @rothbartlab.bsky.social · Dec 4

Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics

DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

Liu et al. report that DNMT1 inhibition causes transient accumulation of hemi-methylated DNA at CpG islands, which stimulates UHRF1-mediated H3K18ub. This enhances SUV39H1/H2 activity, nucleates new H...

www.cell.com

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Reposted by Scott Rothbart

Yael David @davidlabmsk.bsky.social · Dec 4

So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer!

www.nature.com/articles/s43...

Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression - Nature Cancer

Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that ar...

www.nature.com

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Scott Rothbart @rothbartlab.bsky.social · Dec 1

Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu

academic.oup.com

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Reposted by Scott Rothbart

Lempradl Lab @lempradllab.bsky.social · Nov 21

The VAI @vainstitute.bsky.social Graduate School is recruiting Ph.D. students in molecular & cell biology! Get top-tier scientific training, mentorship, and prep for leadership in biomedical research. 🎓 Watch our recruiting video: youtu.be/cOTdF06MekE #PhDSky #BioMedSky

Van Andel Institute Graduate School

YouTube video by Van Andel Institute

youtu.be

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Reposted by Scott Rothbart

Nick Burton @nickburton.bsky.social · Nov 15

Our institute is hiring for a new faculty to join my department at any level! Incredible research support, a great community, a chance to build something while still being at a place already producing top tier research. We start reviewing apps in 2 weeks! vai.wd1.myworkdayjobs.com/en-US/VAICar...

Faculty Position in Metabolism and Nutritional Programming

Van Andel Institute (VAI), a world-class biomedical research institute, located in Grand Rapids, Michigan, is dedicated to improving human health. We are pioneers in the fight against cancer, Parkinso...

vai.wd1.myworkdayjobs.com

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Reposted by Scott Rothbart

Van Andel Institute (VAI) @vai.org · Jul 17

VAI scientists have identified more than 1,000 previously undetected proteins in common metabolite samples. In a new Nature Communications paper, they offer a novel protocol for removing them to improve metabolomics results:
www.vai.org/article/stud...

Study finds persistent proteins may influence metabolomics results

The findings in the Mass Spec Core at Van Andel Institute, published in Nature Communications, give scientists new insights and tools for improving future metabolomics experiments, including a novel p...

www.vai.org

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Scott Rothbart @rothbartlab.bsky.social · Nov 13

Part of the herd migration - hopefully a trend towards the days of old. Seems promising …

Scott Rothbart @rothbartlab.bsky.social · Nov 13

We had a fun lab lunch today celebrating recent acceptances of 2 papers and a new grant! Details to follow. Proud of this team and their accomplishments. #epigenetics

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Scott Rothbart @rothbartlab.bsky.social · Nov 11

please add, thanks Duncan!

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