Lubka Roumenina
@roumenina.bsky.social
Complementologist
Complement system in physiology and pathology
Complement system in physiology and pathology
Reposted by Lubka Roumenina
Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/No5uT9h
Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy - PubMed
Altogether, we show that as renal function declines, a change in the FHR-1:FH ratio combined with changes in heparan sulfate architecture increase complement activity. These findings suggest that…
buff.ly
June 5, 2025 at 2:49 AM
Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/No5uT9h
Reposted by Lubka Roumenina
Interesting to see that FHR proteins have now been found to accumulate in the synovial lining in rheumatoid arthritis, co-localising with C3. Study concluded that FHRs (mainly FHR3) may be driving complement activation. #complement #RA #FHRs buff.ly/b3hOgIX
Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation - PubMed
Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators. We compare…
buff.ly
June 6, 2025 at 2:47 AM
Interesting to see that FHR proteins have now been found to accumulate in the synovial lining in rheumatoid arthritis, co-localising with C3. Study concluded that FHRs (mainly FHR3) may be driving complement activation. #complement #RA #FHRs buff.ly/b3hOgIX
Reposted by Lubka Roumenina
Prévenir les cancers liés au papillomavirus, c’est possible – Agissons !
Des membres du CRC ont co-signé une tribune dans @lemonde.fr, afin de rappeler l'urgence de la vaccination contre les #papillomavirus humains (HPV).
Agir tôt, c’est protéger durablement.
www.linkedin.com/feed/update/...
Des membres du CRC ont co-signé une tribune dans @lemonde.fr, afin de rappeler l'urgence de la vaccination contre les #papillomavirus humains (HPV).
Agir tôt, c’est protéger durablement.
www.linkedin.com/feed/update/...
« Nous sommes malheureusement encore loin des 80 % de couverture vaccinale… | Centre de Recherche des Cordeliers
🎙️ HPV : prévenir les cancers liés au papillomavirus, c’est possible – Agissons !
Des membres du Centre de Recherche des Cordeliers ont co-signé une tribune dans Le Monde, afin de rappeler l'urgen...
www.linkedin.com
June 11, 2025 at 9:06 AM
Prévenir les cancers liés au papillomavirus, c’est possible – Agissons !
Des membres du CRC ont co-signé une tribune dans @lemonde.fr, afin de rappeler l'urgence de la vaccination contre les #papillomavirus humains (HPV).
Agir tôt, c’est protéger durablement.
www.linkedin.com/feed/update/...
Des membres du CRC ont co-signé une tribune dans @lemonde.fr, afin de rappeler l'urgence de la vaccination contre les #papillomavirus humains (HPV).
Agir tôt, c’est protéger durablement.
www.linkedin.com/feed/update/...
Congratulations @nicolasmerle.bsky.social !
Excited to share my first last-author paper! Using in vivo models, transcriptomic analyses, and cellular assays, we demonstrate that HCAR2 acts as a receptor for heme, potentially forming a novel negative feedback loop that promotes Hmox1 expression.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
HCAR2 is a novel receptor for heme
Extracellular heme, released during intravascular hemolysis in sickle cell disease (SCD) and hemolytic anemia acts as a pro-inflammatory danger signal…
www.sciencedirect.com
May 16, 2025 at 3:26 PM
Congratulations @nicolasmerle.bsky.social !
Reposted by Lubka Roumenina
Introducing our new review, "Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis." It explores how the extracellular matrix (ECM) maintains cellular health and how its remodelling reveals genetic disease predispositions.
Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis - PubMed
Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis
buff.ly
April 8, 2025 at 4:30 AM
Introducing our new review, "Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis." It explores how the extracellular matrix (ECM) maintains cellular health and how its remodelling reveals genetic disease predispositions.
A great initiative for early career researchers in @crcordeliers.bsky.social
organized by @zucmanrossi.bsky.social and team!
I am excited about discussing with the participants on scientific communication and the use of social media.
organized by @zucmanrossi.bsky.social and team!
I am excited about discussing with the participants on scientific communication and the use of social media.
🚀 C'est parti pour le Young Investigators Mentoring Symposium au CRC, organisé par le consortium GENIAL en collaboration avec le laboratoire de @zucmanrossi.bsky.social.
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!
April 4, 2025 at 3:11 AM
A great initiative for early career researchers in @crcordeliers.bsky.social
organized by @zucmanrossi.bsky.social and team!
I am excited about discussing with the participants on scientific communication and the use of social media.
organized by @zucmanrossi.bsky.social and team!
I am excited about discussing with the participants on scientific communication and the use of social media.
Excited to share our review: Complement and the hallmarks of cancer - hot off the press in Seminars in Immunology!
Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇
authors.elsevier.com/sd/article/S...
Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
April 4, 2025 at 3:05 AM
Excited to share our review: Complement and the hallmarks of cancer - hot off the press in Seminars in Immunology!
Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇
authors.elsevier.com/sd/article/S...
Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇
authors.elsevier.com/sd/article/S...
Reposted by Lubka Roumenina
Want to learn about the role of the complement system in the response to cytotoxic cancer therapy? Check out our latest review:
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
kwnsfk27.r.eu-west-1.awstrack.me
January 6, 2025 at 9:30 PM
Want to learn about the role of the complement system in the response to cytotoxic cancer therapy? Check out our latest review:
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...