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Ruth Franklin

@ruthfranklinlab.bsky.social

640 followers 350 following 49 posts

Assistant Professor | Harvard Stem Cell & Regenerative Biology | Immunologist and Tissue biologist | Proud mama www.ruthfranklinlab.com

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage

Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

www.science.org

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Ruth Franklin @ruthfranklinlab.bsky.social · 23d

No worries at all, next time!

Ruth Franklin @ruthfranklinlab.bsky.social · 24d

Had a fantastic visit @roswellpark.bsky.social for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!

Mike Feigin 🥯 @mikefeigin.bsky.social · 26d

Very excited to hear from Dr Ruth Franklin as the keynote speaker at the 6th Annual Post-Doctoral Symposium at Roswell Park! @ruthfranklinlab.bsky.social

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Ruth Franklin @ruthfranklinlab.bsky.social · Aug 21

Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower

Ivan Zanoni @lozanzi.bsky.social · Aug 21

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

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Ruth Franklin @ruthfranklinlab.bsky.social · Aug 6

Super cool work, Ryan et al!!

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 26

Thanks, Xu!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 18

Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...

Regulation of inflammatory responses by pH-dependent transcriptional condensates

Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…

www.sciencedirect.com

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 12

Thanks so much!

Reposted by Ruth Franklin

Ivan Zanoni @lozanzi.bsky.social · Jul 12

#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage

www.science.org

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thanks so much, Mohamed!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thanks, Megan!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thanks!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thanks, Igor! We’re super excited!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you, Sunny!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!

Reposted by Ruth Franklin

Alan Y. Baez Vazquez @aybv.bsky.social · Jul 10

I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠

www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage

www.science.org

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thanks, Ryan!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

Thank you!!

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

This project first started during my postdoc w/ Ruslan Medzhitov and I’m extremely grateful for his support! And finally, thank you to the reviewers, @sarahhross.bsky.social & the team @science.org, we’re thrilled to see this story in print! 9/fin

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

A huge thank you to the incredible members of my lab who made it all happen, especially @daisyah.bsky.social & Patricia, and all the coauthors for their contributions along the way! 8/n

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Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

tldr: Macrophage-derived OSM enables lung repair during inflammation. This opens the door to therapies that stimulate repair without compromising antiviral responses. 7/n

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