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Kota Saito

@saitolab.bsky.social

23 followers 40 following 2 posts

Akita University, Graduate School of Medicine Cell Biology, ER exit site, Secretion, Collagen

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Kota Saito @saitolab.bsky.social · Jun 20

This is my first post. We are very happy to share the following preprint!

Our work introduces a novel concept that the functional state of the ERES is maintained through the autoregulated phosphorylation–dephosphorylation cycle of key scaffold proteins.

www.biorxiv.org/content/10.1...

Reposted by Kota Saito

Lisa Heinke @lisaheinke.bsky.social · 9d

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

Ishier Raote @ishier.bsky.social · 9d

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

Reposted by Kota Saito

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 9d

New Online! Towards a unified framework for the function of endoplasmic reticulum exit sites

Towards a unified framework for the function of endoplasmic reticulum exit sites

Nature Reviews Molecular Cell Biology, Published online: 29 September 2025; doi:10.1038/s41580-025-00899-0Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

Kota Saito @saitolab.bsky.social · Jul 31

Our lab website has been updated!　 ksaitolab.com

Saito Lab｜Akita University

Department of Biological Informatics and Experimental Therapeutics Graduate School of Medicine, Akita University 秋田大学大学院医学系研究科情報制御学・実験治療学講座（旧薬理学講座）

Reposted by Kota Saito

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jun 20

Phosphorylation-Coupled Autoregulation Maintains Functional ER Exit Sites https://www.biorxiv.org/content/10.1101/2025.06.18.660491v1

Kota Saito @saitolab.bsky.social · Jun 20

This is my first post. We are very happy to share the following preprint!

Our work introduces a novel concept that the functional state of the ERES is maintained through the autoregulated phosphorylation–dephosphorylation cycle of key scaffold proteins.

www.biorxiv.org/content/10.1...