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@saligramalab.bsky.social

540 followers 340 following 300 posts

#TCR and #human diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. Studying T cells in brain doesn't make me a neuroimmunologist!

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saligramalab.bsky.social @saligramalab.bsky.social · Jun 12

Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026

a cartoon of an astronaut with the words we need you written below him

ALT: a cartoon of an astronaut with the words we need you written below him

media.tenor.com

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saligramalab.bsky.social @saligramalab.bsky.social · 13h

perhaps a difference of opinion between European and American neurologists!!

saligramalab.bsky.social @saligramalab.bsky.social · 14h

In fact, I wrote a grant and proposed to use 2d2xIgHMOG mice as a model for MOGAD..... #reviewers #KILLED the heck out of me. This paper says -"double-transgenic TCRMOG (2D2) × IgHMOG (TH) mouse strain that has been considered a model of human MOGAD" Ha!

Reposted

Daniel Mucida @danmucida.bsky.social · 22h

The begginig of the end. It will only get worse share.google/oLjrBb5k67vJ...

Nearly 20 Percent Fewer International Students Traveled to the U.S. in August

The data shows the steepest decline in August international student arrivals since the pandemic.

share.google

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saligramalab.bsky.social @saligramalab.bsky.social · 23h

#Reticular #chemistry is the #word of the #day @NobelPrize #Congratulations to #chemistry #laureates www.nobelprize.org/prizes/chemi...

Nobel Prize in Chemistry 2025

The Nobel Prize in Chemistry 2025 was awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal-organic frameworks.”

www.nobelprize.org

saligramalab.bsky.social @saligramalab.bsky.social · 23h

Does #bluesky still #exist or is it #dead?

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saligramalab.bsky.social @saligramalab.bsky.social · 1d

Equally, congratulations to Dr. Powrie and others on major discoveries/contributions to the field of Treg biology!

saligramalab.bsky.social @saligramalab.bsky.social · 2d

www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

saligramalab.bsky.social @saligramalab.bsky.social · 3d

I #AGREE "Functional characterization and transcriptomic mapping of T cells remain #incomplete without knowledge of their #clonal #antigenic #specificities. www.biorxiv.org/content/10.1...

Discovery of rare antigen-specific TCRs via replicate profiling

Development of effective vaccines and targeted immunotherapies for cancer, autoimmunity, allergy, and infectious diseases requires comprehensive understanding of functionality and antigenic specificit...

www.biorxiv.org

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saligramalab.bsky.social @saligramalab.bsky.social · 4d

Of course, congratulations

saligramalab.bsky.social @saligramalab.bsky.social · 5d

Beautiful paper, worth a read, lots of #TCR work -of course I am biased as I love #TCRs www.science.org/doi/10.1126/...

Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity

Clonal recruitment is governed by a T cell receptor avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality.

www.science.org

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saligramalab.bsky.social @saligramalab.bsky.social · 5d

As much as AI is exploding....there is still a #huge place for actual #structural #biology #studies. Validating what is inferred through #bioinformatics is #equally #important

saligramalab.bsky.social @saligramalab.bsky.social · 8d

Its #official, after much thought I #resubmitted previously #scored (5 percentile) #R01 #NIH as per suggestion from....another #cycle another #grant submitted! Really hoping it is not going to be a #ND

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saligramalab.bsky.social @saligramalab.bsky.social · 9d

National Cancer Institute has a #director www.nih.gov/news-events/...

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute

Dr. Letai will serve as NCI’s 18th director.

www.nih.gov

saligramalab.bsky.social @saligramalab.bsky.social · 14d

Open science accelerates discovery www.hhmi.org/research/ope...

Open Science | HHMI

Science only progresses as quickly as it is shared. Learn more about HHMI's Open Science initiative.

www.hhmi.org

saligramalab.bsky.social @saligramalab.bsky.social · 14d

#nightscience needs some #young #blood -when you ask for #establishment for #ideas -one gets #established #ideas!!

saligramalab.bsky.social @saligramalab.bsky.social · 17d

Interesting and facts www.psypost.org/a-40-year-st...

A 40-year study finds higher science funding under Republicans

A 40-year study of U.S. government spending found that federal science programs received more funding when Republicans controlled the House and presidency.

www.psypost.org

saligramalab.bsky.social @saligramalab.bsky.social · 20d

"America the land of freedom" -I have many things to say about that....wait, I may be #cancelled

saligramalab.bsky.social @saligramalab.bsky.social · 23d

if #your #appearance #lowers #poeple's #expectations #you #will #surprise #them

saligramalab.bsky.social @saligramalab.bsky.social · 27d

After five years ….we moved today from tiny closet to a brand new lab space with windows!!!

saligramalab.bsky.social @saligramalab.bsky.social · Sep 3

Hot off the #press!!! NIH budget

saligramalab.bsky.social @saligramalab.bsky.social · Aug 21

Congratulations to Hongbo Gao and
@lshanlab.bsky.social www.sciencedirect.com/science/arti...

BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4+ T cells

Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4+ T cells in people living with HIV-1. Most long-lived viral reservoir cells are in…

www.sciencedirect.com

saligramalab.bsky.social @saligramalab.bsky.social · Aug 20

#Congratulations to Andrew Koh’s team at @UChicagoCOI on this paper www.nature.com/articles/s41...

Thymic epithelial cells amplify epigenetic noise to promote immune tolerance - Nature

The activity of the tumour-suppressor protein p53 is repressed in the thymus to augment fluctuations in background chromatin accessibility as a means of mediating ectopic gene expressio...

www.nature.com

saligramalab.bsky.social @saligramalab.bsky.social · Aug 15

Thanks so much!

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saligramalab.bsky.social @saligramalab.bsky.social · Aug 15

does anyone have suggestion for good service provider for #scientific #journal #cover #image?

saligramalab.bsky.social @saligramalab.bsky.social · Aug 15

#Passive #defeatism -one doesn’t need to understand everything. Don’t be fooled in the current structure of multiomics data -not everything is known or will be resolved with generating massive data. There are many questions #unanswered in #science