Sam Burns
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Sam Burns
@samanthabrns.bsky.social
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samanthabrns.bsky.social
#PITT_IDFall25
Estimation of prevention-effective CAB-LA concentrations among men who have sex with men (MSM) and transgender women (TGW) in HPTN 083
This nested case-control study among participants in the HPTN 083 trial found that maintaining consistent plasma Cabotegravir concentrations ≥4x PA-IC90 (0
academic.oup.com
November 10, 2025 at 1:46 AM
samanthabrns.bsky.social
#PITT_IDFall25
Restoring TB-specific Immunity in Early HIV Infection—the Dual Promise of Early Antiretroviral and TB Preventive Treatment
Abstract. Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, maki
academic.oup.com
November 9, 2025 at 11:50 PM
samanthabrns.bsky.social
#PITT_IDFall25
Risk and response adapted treatment in pediatric Epstein-Barr virus associated hemophagocytic lymphohistiocytosis
A cytokine- and clinical-based risk stratification system, combined with dynamic response assessment, enables tailored treatment for pediatric EBV-HLH pati
academic.oup.com
November 3, 2025 at 5:38 PM
samanthabrns.bsky.social
#PITT_IDFall25
Pneumococcal Serotype Distribution and Coverage of Existing and Pipeline Pneumococcal Vaccines
Across pneumococcal conditions, pneumococcal conjugate vaccine (PCV) coverage and preventable burdens were lowest for PCV15 and highest for PCV31, with PCV
academic.oup.com
November 3, 2025 at 5:37 PM
samanthabrns.bsky.social
#PITT_IDFall25
Vaccine Effectiveness Against Influenza A(H1N1), A(H3N2), and B-Associated Hospitalizations, United States, 1 September 2023 to 31 May 2024
This article provides differential VE against influenza-associated hospitalization during 2023–2024 for all 3 relevant subtypes/lineage (A/H1N1, A/H3N2, an
academic.oup.com
October 26, 2025 at 2:58 PM
samanthabrns.bsky.social
#PITT_IDFall25
Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis
Silent cerebral infarctions are common in children with tuberculous meningitis of mild severity. This study links these infarctions to elevated systemic MM
academic.oup.com
October 26, 2025 at 2:58 PM
samanthabrns.bsky.social
#PITT_IDFall25
Community-acquired pneumonia
Community-acquired pneumonia is a major global health challenge that disproportionately affects vulnerable populations, including older people, immunocompromised people, those with chronic conditions,...
www.thelancet.com
October 20, 2025 at 5:07 PM
samanthabrns.bsky.social
#PITT_IDFall25
www.lifescience.net
October 20, 2025 at 5:05 PM
samanthabrns.bsky.social
#PITT_IDFall25
Uncovering the Challenges of Multidrug-Resistant Klebsiella Infections | Contagion Live
The Center for Discovery and Innovation’s Barry Kreiswirth, PhD, discusses this emerging challenge that is ongoing in both the community and healthcare settings, especially around resistant urinary tr...
www.contagionlive.com
October 13, 2025 at 9:31 PM
samanthabrns.bsky.social
#PITT_IDFall25
Congenital Toxoplasmosis: Fewer Clinical Signs at 3 Years of Age Over the Last 15 Years but Stable Risk of Materno-fetal Transmission
Abstract. The risk and severity of congenital toxoplasmosis were estimated using data from 2455 consecutive mother–child pairs. Clinical signs at 3 years w
academic.oup.com
October 13, 2025 at 9:30 PM
samanthabrns.bsky.social
#PITT_IDFall25
Restoring TB-specific immunity in early HIV infection—the dual promise of early antiretroviral and TB preventive treatment
Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tubercu
academic.oup.com
October 6, 2025 at 6:39 PM
samanthabrns.bsky.social
#PITT_IDFall25
Household Molecular Epidemiology of Streptococcus pyogenes Carriage and Infection in The Gambia
First molecular analysis of S pyogenes skin carriage in Africa. Skin carriage may be an important reservoir in RHD-endemic settings. · Highest strain diver
academic.oup.com
October 6, 2025 at 6:37 PM
samanthabrns.bsky.social
#PITT_IDFall25
Cluster-randomized Controlled Trial of Enhanced Carbapenem-resistant Enterobacterales Prevention Program in General Medicine Wards, Siriraj Hospital
In a resource-limited setting at Siriraj Hospital, a cluster-randomized trial in six medical wards compared enhanced CRE prevention—including education, al
academic.oup.com
September 29, 2025 at 6:11 PM
samanthabrns.bsky.social
#PITT_IDFall25
How Wolbachia bacteria could help us tackle some of the world’s most neglected tropical diseases
A common bacterium can dramatically reduce the spread of dengue fever and other tropical diseases.
ourworldindata.org
September 29, 2025 at 6:09 PM
samanthabrns.bsky.social
#PITT_IDFall25
Merck’s Enflonsia (clesrovimab) gets positive EMA CHMP opinion for infant RSV prevention
Merck’s single-dose, weight-independent antibody provides about five months of protection; EC decision pending, and it is already FDA approved in the United States.
www.contagionlive.com
September 23, 2025 at 1:16 AM
samanthabrns.bsky.social
#PITT_IDFall25
Efficacy of Primaquine for the Radical Cure of Plasmodium vivax Malaria in Northeast Myanmar and the Impact of Cytochrome P450 2D6 Genotypes
This study evaluated chloroquine and 14-day low-dose primaquine as directly observed therapy for Plasmodium vivax malaria in the Greater Mekong subregion a
academic.oup.com
September 23, 2025 at 1:11 AM
samanthabrns.bsky.social
#PITT_IDFall25
USDA confirms first H5N1 avian flu detection in Nebraska dairy cows
Nebraska's agriculture department says the herd is located in the central part of the state and is under quarantine.
www.cidrap.umn.edu
September 16, 2025 at 5:25 PM
samanthabrns.bsky.social
#PITT_IDFall25
27 sickened by salmonella in outbreak linked to dog food and treats
VANCOUVER - The Canadian Food Inspection Agency says 27 people have been sickened with salmonella, mostly in Alberta and British Columbia, in an outbreak linked to contaminated dog food and
www.thecanadianpressnews.ca
September 16, 2025 at 5:24 PM
samanthabrns.bsky.social
#PITT_IDFall25
Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity
Author summary This study addresses the passive transfer and inter-generational inheritance of functionally potent antibodies, and the relative ability of IgG antibodies to drive broad recognition and...
journals.plos.org
September 8, 2025 at 8:21 PM
samanthabrns.bsky.social
#PITT_IDFall25
CDC Reports Outbreak of Neisseria meningitidis Conjunctivitis Among Military Trainees in Texas
41 cases of nongroupable N meningitidis conjunctivitis were identified at Joint Base San Antonio-Lackland, highlighting diagnostic, treatment, and surveillance implications for congregate living setti...
www.contagionlive.com
September 8, 2025 at 8:20 PM
samanthabrns.bsky.social
#PITT_ID25
Mosquito feeding habits could influence disease spread | Edinburgh Infectious Diseases | Edinburgh Infectious Diseases
August 2025: A recent study involving researchers from the Roslin Institute shows how feeding preference may sustain transmission of mosquito-borne viruses.
edinburgh-infectious-diseases.ed.ac.uk
September 2, 2025 at 12:59 AM
samanthabrns.bsky.social
#PITT_ID25 Relevant to rheumatoid arthritis and other rheumatic diseases we are learning about in class.
Continuation versus temporary interruption of immunomodulatory agents during infections in patients with inflammatory rheumatic diseases: a randomized controlled trial
AbstractBackground. Immunomodulatory agents (IA) are commonly used to treat inflammatory rheumatic diseases (IRDs). Guidelines typically recommend temporar
academic.oup.com
September 2, 2025 at 12:58 AM
samanthabrns.bsky.social
#PITT_ID25
Transmission of group A Streptococcus in long-term care: An outbreak investigation
We report 2 outbreaks comprising a cluster of 18 group A Streptococcal infections across 2 nursing facilities. Point prevalence surveillance testing identified 8 of 18 cases, and whole genome sequenci...
www.ajicjournal.org
April 27, 2025 at 4:51 PM
samanthabrns.bsky.social
#PITT_ID25
Human Infection with a Novel Tickborne Orthonairovirus Species in China | NEJM
This report describes a novel tickborne orthonairovirus species identified in patients presenting with an acute febrile illness in China.
www.nejm.org
April 27, 2025 at 4:50 PM
samanthabrns.bsky.social
#PITT_ID25
FDA fast tracks Sanofi’s mRNA vaccine for chlamydia - Pharmaceutical Technology
Sanofi will commence a Phase I/II trial with its vaccine candidate in the next few days to start generating immunogenicity data.
www.pharmaceutical-technology.com
April 21, 2025 at 1:36 PM