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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB
@sc-lab.bsky.social
110 followers 360 following 8 posts
Laboratory of structural biology of macromolecular assemblies and cytoskeletal proteins at CSIR-CCMB, Hyderabad, India. Previously at Stony Brook University(2018-2021).
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 22d
Nice work @cryoet.bsky.social and congratulations to you and your group
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 22d
Congratulations @drmichaelway.bsky.social , Carolyn and @tianyang22.bsky.social for the wonderful work. Happy to see that this is similar to our observations @natsmb.nature.com bit.ly/41T60R2 . Happy that both the independent studies came out together.
Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation - Nature Structural & Molecular Biology
Francis et al. used cryo-electron microscopy to show how a SPIN90 dimer activates the metazoan Arp2/3 complex to nucleate linear actin filaments for unidirectional and bidirectional growth, forming po...
bit.ly
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 23d
A SPIN90 dimer can either interact with a single Arp2/3 complex or two Arp2/3 complexes there either nucleating uni or bidirectional actin filaments, that can lead to multidirectional actin networks in cells for various processes. #cytoskeleton, #actin, #cellbiology
sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 23d
This study highlights the importance of the middle segment of SPIN90 and how it helps in its dimerisation. This is critical for each SPIN90 molecule to make unique activating interactions with different Arp2/3 complex subunits.
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 23d
Also thanks to our collabotors Heidy Ortiz and Brad Nolen from @universityoforegon.bsky.social. This work would not have been possible without the support of #CSIR-India and #CSIR-CCMB.
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · 23d
Happy to share our lab's recent #cryoEM studies that show how a SPIN90 dimer activates Arp2/3 complex to form either uni or bidirectional actin filaments. Congrats🎉👏 @justusfrancis.bsky.social @achyutha-kp.bsky.social @tejashyamk.bsky.social @sridharskulkarni.bsky.social @kiranvyshnav.bsky.social
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · 23d
New online: Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation
Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation
Nature Structural & Molecular Biology, Published online: 15 September 2025; doi:10.1038/s41594-025-01673-8Francis et al. used cryo-electron microscopy to show how a SPIN90 dimer activates the metazoan Arp2/3 complex to nucleate linear actin filaments for unidirectional and bidirectional growth, forming potential scaffolds for rapid assembly of dynamic actin networks.
go.nature.com
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sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · Jan 25
We have now migrated from X (@SaikatLab) to the blue zone.
sc-lab.bsky.social
Saikat's_Lab@CSIR-CCMB @sc-lab.bsky.social · Jan 25
Congrats! That is a big move. Wish you all the best!