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Reposted by Scheiffele Lab

Zeynep Okur @zeynepokur.bsky.social · Jun 11

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation

Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

www.sciencedirect.com

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Scheiffele Lab @scheiffelelab.bsky.social · Mar 24

Great Lab and a great project!

Postdoc position: Synaptic specificity in cortical and thalamocortical circuits - VIB

Overview The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the KU Leuven, which ranks among the world’s top 50 universities. At ou...

jobs.vib.be

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 28

Same here -

How Canadians Are Directing Their Ire at the U.S. Over Trump’s Tariffs

Canadians are shunning American products and abandoning trips to the United States to protest the economic punishment President Trump has threatened to impose with tariffs.

www.nytimes.com

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 27

Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!

Transcriptomic neuron types vary topographically in function and morphology - Nature

Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...

www.nature.com

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 21

Important article on the urgent question how to upkeep key information platforms for science

Science must step away from nationally managed infrastructure

Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…

www.thetransmitter.org

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 12

Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus

Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...

www.biorxiv.org

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 12

Exciting job opportunity in Europe!

Group Leader - Molecular Mechanisms of Environmental Adaptation

We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

embl.wd103.myworkdayjobs.com

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 11

Congratulations!!!

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Reposted by Scheiffele Lab

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jan 16

Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1

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Scheiffele Lab @scheiffelelab.bsky.social · Feb 10

Beautiful example of spatial proteomic dissection
of synapse diversity from De Wit Lab!

Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed

Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...

pubmed.ncbi.nlm.nih.gov

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Reposted by Scheiffele Lab

Harmit Singh Malik @harmitmalik.bsky.social · Jan 28

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

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Scheiffele Lab @scheiffelelab.bsky.social · Jan 29

A great read!

pubmed.ncbi.nlm.nih.gov/39121543/

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Reposted by Scheiffele Lab

Shari Wiseman @shariwiseman.bsky.social · Dec 9

Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.

springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor, Nature Neuroscience

Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...

springernature.wd3.myworkdayjobs.com

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Scheiffele Lab @scheiffelelab.bsky.social · Nov 29

Nothing is better than working with amazing talented people! Congrats Zeynep - so well deserved!

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Scheiffele Lab @scheiffelelab.bsky.social · Nov 25

…and another cool approach to uncover RNA-RNA interactions !
www.cell.com/cell/fulltex...

snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification

Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.

www.cell.com

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Scheiffele Lab @scheiffelelab.bsky.social · Nov 25

Cool method!
www.cell.com/neuron/fullt...

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes

Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation. Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while overexpression prevent...

www.cell.com

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Reposted by Scheiffele Lab

The Elowitz Lab at Caltech @elowitzlab.bsky.social · Nov 25

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...