Steven Cheng
@scheng23.bsky.social
Chemistry & Chemical Biology PhD Candidate @Harvard woolab.org |
Chemical Engineering @Stanford Alumnus |
Small molecules 💊, PTMs (esp O-GlcNAc 🟦), RNA splicing 🧬
Chemical Engineering @Stanford Alumnus |
Small molecules 💊, PTMs (esp O-GlcNAc 🟦), RNA splicing 🧬
Therapeutic potential of allosteric HECT E3 ligase inhibition
www.cell.com/cell/fulltex...
"we discover inhibitors that bind a cryptic cavity distant from the catalytic cysteine"
...
"these inhibitors restrict an essential catalytic motion by extending an α helix over a conserved glycine hinge"
www.cell.com/cell/fulltex...
"we discover inhibitors that bind a cryptic cavity distant from the catalytic cysteine"
...
"these inhibitors restrict an essential catalytic motion by extending an α helix over a conserved glycine hinge"
April 7, 2025 at 4:14 PM
Therapeutic potential of allosteric HECT E3 ligase inhibition
www.cell.com/cell/fulltex...
"we discover inhibitors that bind a cryptic cavity distant from the catalytic cysteine"
...
"these inhibitors restrict an essential catalytic motion by extending an α helix over a conserved glycine hinge"
www.cell.com/cell/fulltex...
"we discover inhibitors that bind a cryptic cavity distant from the catalytic cysteine"
...
"these inhibitors restrict an essential catalytic motion by extending an α helix over a conserved glycine hinge"
Very interesting screening approach leveraging different technologies including DELs, photocleavable linkers, microfluidics, RNA-seq to discover new bioactive VHL molecular glues
March 21, 2025 at 3:06 PM
Very interesting screening approach leveraging different technologies including DELs, photocleavable linkers, microfluidics, RNA-seq to discover new bioactive VHL molecular glues
www.nature.com/articles/s41...
www.nature.com/articles/d41...
A polyene macrolide targeting phospholipids in the fungal cell membrane
New antifungal breaks the mould
"Mandimycin is an antifungal molecule that acts by specifically targeting phospholipids"
www.nature.com/articles/d41...
A polyene macrolide targeting phospholipids in the fungal cell membrane
New antifungal breaks the mould
"Mandimycin is an antifungal molecule that acts by specifically targeting phospholipids"
March 21, 2025 at 3:01 PM
www.nature.com/articles/s41...
www.nature.com/articles/d41...
A polyene macrolide targeting phospholipids in the fungal cell membrane
New antifungal breaks the mould
"Mandimycin is an antifungal molecule that acts by specifically targeting phospholipids"
www.nature.com/articles/d41...
A polyene macrolide targeting phospholipids in the fungal cell membrane
New antifungal breaks the mould
"Mandimycin is an antifungal molecule that acts by specifically targeting phospholipids"
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
January 10, 2025 at 8:00 PM
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
TIL there's an E3 ligase named "itchy"
December 13, 2024 at 3:50 PM
TIL there's an E3 ligase named "itchy"
December 11, 2024 at 5:42 PM
www.pnas.org/doi/10.1073/...
Targeted degradation of Pin1 by protein-destabilizing compounds
“Molecular crowbar” degraders, will be interesting to see generalizability to other targets (BRD4 🫥)
Targeted degradation of Pin1 by protein-destabilizing compounds
“Molecular crowbar” degraders, will be interesting to see generalizability to other targets (BRD4 🫥)
November 21, 2024 at 5:10 PM
www.pnas.org/doi/10.1073/...
Targeted degradation of Pin1 by protein-destabilizing compounds
“Molecular crowbar” degraders, will be interesting to see generalizability to other targets (BRD4 🫥)
Targeted degradation of Pin1 by protein-destabilizing compounds
“Molecular crowbar” degraders, will be interesting to see generalizability to other targets (BRD4 🫥)