Lightnews — Scholar-powered news

Schwalbe Lab @schwalbe-lab.bsky.social · 9d

Our study shows Ephrin A1 undergoes conformational selection when binding EphA2, while its juxtamembrane regions stay flexible. These insights clarify bidirectional signaling and may guide future therapeutic strategies.
Full text: www.sciencedirect.com/science/arti...

#NMR #Ephrin #Cancer #receptor

Structural role of conformational heterogeneity and juxtamembrane regions in the Ephrin A1 interactions with the EphA2 receptor ligand-binding domain

Ephrin growth factors are attached to the membrane by either GPI-anchor or transmembrane domains and are known to signal bi-directionally: cells, expr…

www.sciencedirect.com

1 1

Schwalbe Lab @schwalbe-lab.bsky.social · 13d

Great contribution from our former lab member Robert Silvers in @narjournal.bsky.social ☺️
"Noncanonical RNA binding of human La-related protein 6"
Full text: academic.oup.com/nar/article/...
#LARP #NMR #RNA #structure

Noncanonical RNA binding of human La-related protein 6

academic.oup.com

1 1

Schwalbe Lab @schwalbe-lab.bsky.social · 13d

Take a look at the publication of our former lab member Nina Kubatova in @pnas.org 😇
"Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies"
Full text: www.pnas.org/doi/10.1073/...
#DEER #protein #SingleMolecule #GPCR

Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies | PNAS

G protein–coupled receptors (GPCRs) comprise a large class of membrane proteins that mediate cellular responses to a wide range of external signals...

www.pnas.org

1 2

Schwalbe Lab @schwalbe-lab.bsky.social · 15d

Together with the Evanseck Lab, our lab just published the NMR + MD structure of the Omicron SARS-CoV-2 s2m RNA, revealing a pentaloop with remarkable dynamics.

Full text: m.rnajournal.cshlp.org/content/earl...

#NMR #MD #RNA #SARSCoV2 #structure #dynamics

RNA | Mobile

m.rnajournal.cshlp.org

1 2

Schwalbe Lab @schwalbe-lab.bsky.social · 22d

At the 2025 meeting of the German focus group of Magnetic Resonance (FGMR, EPR/NMR), Harald Schwalbe, Instruct-director, introduced access possibilities and highlighted the recent installation of the German Instruct centre.

@instruct-eric.bsky.social @gdch.de

#NMR #EPR #FGMR #GDCh #InstructERIC

1 5

Schwalbe Lab @schwalbe-lab.bsky.social · Sep 8

Exciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation.
academic.oup.com/nar/article/...

Structural basis for ligand recognition in the tobramycin riboswitch

Abstract. Recently, a novel tobramycin-responsive riboswitch was developed by a combination of Capture-SELEX and in vivo screening. This riboswitch regulat

academic.oup.com

2 5

Reposted by Schwalbe Lab

Instruct-ERIC @instruct-eric.bsky.social · Aug 22

Instruct Director Harald Schwalbe will be in Denmark for the SBiNLab’s 25th anniversary!

www1.bio.ku.dk/english/rese... @schwalbe-lab.bsky.social

Researchers in Denmark can receive access to Instruct technologies and instrumentation here - instruct-eric.org/submit-propo...

New Horizons in Protein Dynamics – Department of Biology - University of Copenhagen

www1.bio.ku.dk

4 5

Schwalbe Lab @schwalbe-lab.bsky.social · Aug 5

Our newest publication is online!
Using fragment-growth guided by NMR spectroscopy, we optimized small molecules targeting SCoV-2 SL1 RNA, integrating solubility, affinity, and specificity to identify translation inhibitors.

Full text: pubs.acs.org/doi/10.1021/...

#NMR #drugdesign #RNA #SARSCoV2

Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight

We present the development of low molecular weight inhibitors that target the 5′-terminal RNA stem-loop 1 (SL1) of the SARS-CoV-2 genome. SL1 is crucial for allowing viral protein synthesis in the con...

pubs.acs.org

2 3

Schwalbe Lab @schwalbe-lab.bsky.social · Jul 31

Check out our newest chemical shift assignment! 🎉
We used NMR to characterize the SL5a stem-loop from HCoV-229E, a conserved RNA element key to coronavirus RNA translation and replication.

doi.org/10.1007/s121...

#RNA #NMR #Virology #StructuralBiology #Assignment #Coronavirus

1H, 13C and 15N chemical shift assignment for stem-loop 5a from the 5‘UTR of HCoV-229E - Biomolecular NMR Assignments

Due to the emergence of the SARS-CoV-2 virus, research on coronaviruses has been massively accelerated. In addition to SARS-CoV-2, there are other human coronaviruses, including HCoV-229E. In all coro...

doi.org

1 3

Reposted by Schwalbe Lab

Magnetic Resonance News @nmr900.bsky.social · Jul 6

RT @euromar2025 EUROMAR 2025 opens in Oulu
A fantastic lineup of prize winners:
🏆 Prof. Thomas Prisner – Richard R. Ernst Prize
🏆 Dr. Nergiz Sahin Solmaz – Raymond Andrew Prize
🏆 Prof. Tuo Wang – Ampere Prize for Young Investigators

Congratulations to all!
#EUROMAR2025 #NMR #EPR #MRI #ESR #NMRchat

3 10

Schwalbe Lab @schwalbe-lab.bsky.social · Jul 3

Workshop Alert: On July 10, Nathalie Weickgenannt and Laura Buglioni from @angewandtechemie.bsky.social will be at Goethe University Frankfurt to host a Wiley Publishing Workshop. Don’t miss this opportunity to gain valuable insights into scientific publishing!

3 4

Schwalbe Lab @schwalbe-lab.bsky.social · Jul 2

New publication is out in @febsopenbio.bsky.social ! 🎉
"NMR screening of low molecular weight inhibitors targeting the papain-like protease (PLPro) of SARS-CoV-2"

Full text: febs.onlinelibrary.wiley.com/doi/10.1002/...

#screening #NMR #SARS-CoV2 #targeting

FEBS Press

Papain-like protease from SARS-CoV-2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR scr...

febs.onlinelibrary.wiley.com

1 3

Schwalbe Lab @schwalbe-lab.bsky.social · Jul 1

New publication in @narjournal.bsky.social - Using NMR, SAXS & MD, we characterize the dynamic nonaloop of the SARS-CoV-2 Delta s2m RNA, contributing to future ensemble-functional studies of dynamic RNA motifs.

Full text: doi.org/10.1093/nar/...

#RNA #StructuralBiology #NAR #NMR #MDSimulations

Structural heterogeneity and dynamics in the apical stem loop of s2m from SARS-CoV-2 Delta by an integrative NMR spectroscopy and MD simulation approach

Abstract. In structured RNAs, helical elements are often capped by apical loops that are integral structural elements, ranging from 3 to >20 nts of size

doi.org

3 8

Schwalbe Lab @schwalbe-lab.bsky.social · Jun 24

x.com/lab_lucio/st...

Lucio Frydman Lab on X: "Destruction was extensive, but thanks to numerous precautions there were zero casualties. The Gigahz, the 7T human, the 15.2T animal and the DNPs, are all up and running. So is the He recycling, and our lower-field 500, 600 solids and liquids machines. So life goes on! https://t.co/vaxW9hx8WP" / X

Destruction was extensive, but thanks to numerous precautions there were zero casualties. The Gigahz, the 7T human, the 15.2T animal and the DNPs, are all up and running. So is the He recycling, and our lower-field 500, 600 solids and liquids machines. So life goes on! https://t.co/vaxW9hx8WP

x.com

1 1 2

Schwalbe Lab @schwalbe-lab.bsky.social · Jun 10

Let's support the Bethesda Declaration and stand up for science together ✍️
actionnetwork.org/petitions/op...

Sign The Open Letter to Stand Up For Science Now!

Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...

actionnetwork.org

1

Schwalbe Lab @schwalbe-lab.bsky.social · May 30

A great overview of methods to investigate RNA modifications 😊
onlinelibrary.wiley.com/doi/full/10....

2 7

Schwalbe Lab @schwalbe-lab.bsky.social · May 26

Prof. José María Carazo has been elected Chair of the Instruct-ERIC Council, with Dr. Evangelia Chrysina as Vice-Chair. Both bring structural biology expertise to further develop European research infrastructure.

@instruct-eric.bsky.social

instruct-eric.org/news/instruc...

Instruct-ERIC New Council Chair and Vice-Chair

Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

instruct-eric.org

4 14

Schwalbe Lab @schwalbe-lab.bsky.social · May 16

Another publication on DNA G-quadruplexes in collaboration with the Heckel group is out! 🎉

"Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter"

Full text: pubs.acs.org/doi/10.1021/...

#G4 #quadruplex #photocages #NMR #VEGF #structure

Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter

The vascular endothelial growth factor (VEGF) promoter region, which is involved in cancer progression, contains guanine-rich sequences capable of forming G-quadruplex (G4) structures. G4s play a crit...

pubs.acs.org

2 3

Schwalbe Lab @schwalbe-lab.bsky.social · May 5

New publication from Robert Silver's lab reporting the NMR assignment of the 5'SL-bound La domain of human La-related protein 6 (HsLARP6). Congratulations!

Full text:
link.springer.com/article/10.1...

1H, 13C, and 15N resonance assignment of the 5’SL-bound La domain of the human La-related protein 6 - Biomolecular NMR Assignments

link.springer.com

2 3

Schwalbe Lab @schwalbe-lab.bsky.social · May 5

Congratulations to Hashim Al-Hashimi on his election to the American Academy of Arts and Sciences! We are thrilled to see his outstanding work being recognized.
🔗 news.columbia.edu/news/three-c...

Three Columbia Faculty Members Elected to the American Academy of Arts and Sciences

The academy honors excellence across a wide range of fields, including academia, business, public affairs, and the arts.

news.columbia.edu

2 11

Schwalbe Lab @schwalbe-lab.bsky.social · Apr 28

Check out our latest assignment note 🥳
'NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA'

Full text: link.springer.com/article/10.1...

#NMR #RNA #m6a #Erythromycinmethyltransferase

NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA - Biomolecular NMR Assignments

The increasing prevalence of antibiotic resistance represents a significant public health concern, underscoring the urgent need for the development of novel therapeutic strategies. The antibiotic effe...

link.springer.com

2 5

Schwalbe Lab @schwalbe-lab.bsky.social · Apr 22

Check out our latest publication on DNA G-quadruplexes! We show how the ligand Phen-DC3 modulates the folding of the human telomeric repeat 23TAG DNA, providing insights into the modulation of G4 folding.

Read more here 👉 doi.org/10.1002/chem...

#DNA #GQuadruplex #folding #kinetics #realtime #NMR

Exploring the modulation of the complex folding landscape of Human Telomeric DNA by low molecular weight ligands

Telomeric DNA forms G-quadruplex (G4) structures. These G4s structures are crucial for genomic stability and therapeutic targeting. Using time-resolved NMR and CD spectroscopies, we investigated how ...

doi.org

3 3

Schwalbe Lab @schwalbe-lab.bsky.social · Apr 16

Two of our publications are among the most widely read papers in Chemistry and ChemMedChem! 🤩🎉
#EPHA2 #colorectalcancer #drugdiscovery

Full text here:
chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

2

Schwalbe Lab @schwalbe-lab.bsky.social · Apr 14

The newest collaboration project has been published! Congrats to the group of @m-grininger.bsky.social 🥳

'Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases'

Full text link: www.sciencedirect.com/science/arti...

Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases

Acyl carrier proteins (ACPs) are key domains in fatty acid and polyketide synthases (PKSs), shuttling intermediates to catalytic partners. Here, we pr…

www.sciencedirect.com

3 5

Schwalbe Lab @schwalbe-lab.bsky.social · Mar 24

In February 2025, Instruct-ERIC Director Prof. Harald Schwalbe visited the Instruct-ERIC center in Israel.

Visit here for the full report: instruct-eric.org/news/focus-o...

Focus on: Instruct-IL

Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

instruct-eric.org

1 1