J Scotch McClure
@scotchmcclure.bsky.social
CEO @ Maxwell Biosciences - developing a Synthetic Immune System - science shows it is effective vs viruses, fungi & bacteria. MaxwellBiosciences.com
🧵 https://bsky.app/profile/scotchmcclure.bsky.social/post/3kktsqq7j222a
🧵 https://bsky.app/profile/scotchmcclure.bsky.social/post/3kktsqq7j222a
Swollen and red, front and back, and when I massage it my right wrist throbs. Absolutely bizarre, intense, aching, burning pain.
The mystery of long COVID never ends.
The mystery of long COVID never ends.
February 16, 2024 at 5:08 AM
Swollen and red, front and back, and when I massage it my right wrist throbs. Absolutely bizarre, intense, aching, burning pain.
The mystery of long COVID never ends.
The mystery of long COVID never ends.
Excellent question. We are doing so. The exact list of trial inclusions exclusion has not been finalized, and we’re open to your thoughts on the topic.
February 9, 2024 at 4:03 PM
Excellent question. We are doing so. The exact list of trial inclusions exclusion has not been finalized, and we’re open to your thoughts on the topic.
Wow that looks absolutely amazing
February 8, 2024 at 12:20 AM
Wow that looks absolutely amazing
Workin on it. Hard AF!
💪🏼👨🏻🔬 good science takes time especially when the government no longer recognizes national emergency expedite.
💪🏼👨🏻🔬 good science takes time especially when the government no longer recognizes national emergency expedite.
February 7, 2024 at 10:16 PM
Workin on it. Hard AF!
💪🏼👨🏻🔬 good science takes time especially when the government no longer recognizes national emergency expedite.
💪🏼👨🏻🔬 good science takes time especially when the government no longer recognizes national emergency expedite.
Common comorbidity, for sure. MTHFR polymorphism —> lower levels of methylcobalamin and folate —> difficulty repairing DNA, and also impaired methylation. Thus, weakening immune function as well as control how genes are turned on or off, making it easier for infections to sneak past our defenses.
February 7, 2024 at 10:15 PM
Common comorbidity, for sure. MTHFR polymorphism —> lower levels of methylcobalamin and folate —> difficulty repairing DNA, and also impaired methylation. Thus, weakening immune function as well as control how genes are turned on or off, making it easier for infections to sneak past our defenses.
When?
We’re kicking around logistics and financing right now to try to fit in #LongCOVID FDA phase 1b human trials in 2025.
Very rough date and certain to move around a bit.
We’re kicking around logistics and financing right now to try to fit in #LongCOVID FDA phase 1b human trials in 2025.
Very rough date and certain to move around a bit.
February 7, 2024 at 5:59 PM
When?
We’re kicking around logistics and financing right now to try to fit in #LongCOVID FDA phase 1b human trials in 2025.
Very rough date and certain to move around a bit.
We’re kicking around logistics and financing right now to try to fit in #LongCOVID FDA phase 1b human trials in 2025.
Very rough date and certain to move around a bit.
17. How We Invented the Tech
Mimicking the human innate immune system, how we did it.
VIDEO:
m.youtube.com/watch?v=INJn...
Mimicking the human innate immune system, how we did it.
VIDEO:
m.youtube.com/watch?v=INJn...
https://m.youtube.com/watch?v=INJnp5qLk6Y&feature=youtu.be
m.youtube.com
February 7, 2024 at 5:58 PM
17. How We Invented the Tech
Mimicking the human innate immune system, how we did it.
VIDEO:
m.youtube.com/watch?v=INJn...
Mimicking the human innate immune system, how we did it.
VIDEO:
m.youtube.com/watch?v=INJn...
16. Our FDA docs were submitted for our first “Pre-IND” meeting and we received highly supportive FDA feedback.
Read more about our tech, science and plan to treat #LongCOVId here: maxwellbiosciences.com/technology
🙏🏼 Pray that we are successful. I believe it’s the world’s best hope.
Read more about our tech, science and plan to treat #LongCOVId here: maxwellbiosciences.com/technology
🙏🏼 Pray that we are successful. I believe it’s the world’s best hope.
Claromer Technology to Fight Long COVID — Maxwell Biosciences
To fight Long COVID, brain fungal infections and other polymicrobial
infections you would need something that is able to tackle many types of
infections at once. DARPA funded this concept as a "synt...
maxwellbiosciences.com
February 7, 2024 at 5:57 PM
16. Our FDA docs were submitted for our first “Pre-IND” meeting and we received highly supportive FDA feedback.
Read more about our tech, science and plan to treat #LongCOVId here: maxwellbiosciences.com/technology
🙏🏼 Pray that we are successful. I believe it’s the world’s best hope.
Read more about our tech, science and plan to treat #LongCOVId here: maxwellbiosciences.com/technology
🙏🏼 Pray that we are successful. I believe it’s the world’s best hope.
15. The University of Texas Medical Branch confirmed our study on our “CLAROMER” brand molecule using an electron microscope in their bio containment level 3 (BSL-3) lab. You can see it disintegrates the viral envelope.
February 7, 2024 at 5:55 PM
15. The University of Texas Medical Branch confirmed our study on our “CLAROMER” brand molecule using an electron microscope in their bio containment level 3 (BSL-3) lab. You can see it disintegrates the viral envelope.
14. Here’s how your immune system peptide “LL-37” works (and how our potential drug works).
It targets a type of fat that only shows up in diseased or infected cells, and pathogens. This is how your immune system knows when to use it. Same with our molecule.
It targets a type of fat that only shows up in diseased or infected cells, and pathogens. This is how your immune system knows when to use it. Same with our molecule.
February 7, 2024 at 5:54 PM
14. Here’s how your immune system peptide “LL-37” works (and how our potential drug works).
It targets a type of fat that only shows up in diseased or infected cells, and pathogens. This is how your immune system knows when to use it. Same with our molecule.
It targets a type of fat that only shows up in diseased or infected cells, and pathogens. This is how your immune system knows when to use it. Same with our molecule.
13. The drug candidate is highly potent while remaining safe in animals and in preclinical human lung tissue. Tested in mice, rats, and Fauci’s team at NIH NAIAD tested in Syrian hamsters for us.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphip...
Scientific Reports - Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids
www.nature.com
February 7, 2024 at 5:53 PM
13. The drug candidate is highly potent while remaining safe in animals and in preclinical human lung tissue. Tested in mice, rats, and Fauci’s team at NIH NAIAD tested in Syrian hamsters for us.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
12. This is a world-first scientific breakthrough, mostly been overlooked by popular media.
A drug candidate that kills herpes, all tested corona viruses, all tested influenza, all pathogenic bacteria, fungus, mold, yeast and biofilms - AND is safe in animal tests.
Notable?
A drug candidate that kills herpes, all tested corona viruses, all tested influenza, all pathogenic bacteria, fungus, mold, yeast and biofilms - AND is safe in animal tests.
Notable?
February 7, 2024 at 5:51 PM
12. This is a world-first scientific breakthrough, mostly been overlooked by popular media.
A drug candidate that kills herpes, all tested corona viruses, all tested influenza, all pathogenic bacteria, fungus, mold, yeast and biofilms - AND is safe in animal tests.
Notable?
A drug candidate that kills herpes, all tested corona viruses, all tested influenza, all pathogenic bacteria, fungus, mold, yeast and biofilms - AND is safe in animal tests.
Notable?
11. We found a way to mimic LL-37 in the form of a small molecule - not a peptide.
We attached the functional portions that make LL-37 work to a stable chemical backbone.
We published stable efficacy against SARS-CoV-2, Herpes, bacteria, etc
pubmed.ncbi.nlm.nih.gov/33807248/
We attached the functional portions that make LL-37 work to a stable chemical backbone.
We published stable efficacy against SARS-CoV-2, Herpes, bacteria, etc
pubmed.ncbi.nlm.nih.gov/33807248/
Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids - PubMed
Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these in...
pubmed.ncbi.nlm.nih.gov
February 7, 2024 at 5:50 PM
11. We found a way to mimic LL-37 in the form of a small molecule - not a peptide.
We attached the functional portions that make LL-37 work to a stable chemical backbone.
We published stable efficacy against SARS-CoV-2, Herpes, bacteria, etc
pubmed.ncbi.nlm.nih.gov/33807248/
We attached the functional portions that make LL-37 work to a stable chemical backbone.
We published stable efficacy against SARS-CoV-2, Herpes, bacteria, etc
pubmed.ncbi.nlm.nih.gov/33807248/
10. Human Cathelicidin Antimicrobial Peptide “LL-37”
LL-37 is a possible “super drug” because it kills all the bad bugs. The problem is nobody has been able to find a way to stabilize it. Bacteria create anti-LL-37 enzymes that eat LL-37. It’s a battle.
www.ncbi.nlm.nih.gov/pmc/articles...
LL-37 is a possible “super drug” because it kills all the bad bugs. The problem is nobody has been able to find a way to stabilize it. Bacteria create anti-LL-37 enzymes that eat LL-37. It’s a battle.
www.ncbi.nlm.nih.gov/pmc/articles...
The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic ...
www.ncbi.nlm.nih.gov
February 7, 2024 at 5:50 PM
10. Human Cathelicidin Antimicrobial Peptide “LL-37”
LL-37 is a possible “super drug” because it kills all the bad bugs. The problem is nobody has been able to find a way to stabilize it. Bacteria create anti-LL-37 enzymes that eat LL-37. It’s a battle.
www.ncbi.nlm.nih.gov/pmc/articles...
LL-37 is a possible “super drug” because it kills all the bad bugs. The problem is nobody has been able to find a way to stabilize it. Bacteria create anti-LL-37 enzymes that eat LL-37. It’s a battle.
www.ncbi.nlm.nih.gov/pmc/articles...
9. The Human Immune System
Your immune cells use a single peptide - Human Cathelicidin Antimicrobial Peptide (aka “LL-37) to tackle all of those bugs.
What if we could make a drug to mimic that peptide?
Your immune cells use a single peptide - Human Cathelicidin Antimicrobial Peptide (aka “LL-37) to tackle all of those bugs.
What if we could make a drug to mimic that peptide?
February 7, 2024 at 5:49 PM
9. The Human Immune System
Your immune cells use a single peptide - Human Cathelicidin Antimicrobial Peptide (aka “LL-37) to tackle all of those bugs.
What if we could make a drug to mimic that peptide?
Your immune cells use a single peptide - Human Cathelicidin Antimicrobial Peptide (aka “LL-37) to tackle all of those bugs.
What if we could make a drug to mimic that peptide?
8. PROBLEM, **very difficult**
So, it’s lots of pathogens and it’s a different mix of bugs for each patient. In order to best it we need a drug that stops enveloped viruses, pathogenic bacteria, fungus, mold, yeast AND biofilms.
We have a potential solution…
So, it’s lots of pathogens and it’s a different mix of bugs for each patient. In order to best it we need a drug that stops enveloped viruses, pathogenic bacteria, fungus, mold, yeast AND biofilms.
We have a potential solution…
February 7, 2024 at 5:49 PM
8. PROBLEM, **very difficult**
So, it’s lots of pathogens and it’s a different mix of bugs for each patient. In order to best it we need a drug that stops enveloped viruses, pathogenic bacteria, fungus, mold, yeast AND biofilms.
We have a potential solution…
So, it’s lots of pathogens and it’s a different mix of bugs for each patient. In order to best it we need a drug that stops enveloped viruses, pathogenic bacteria, fungus, mold, yeast AND biofilms.
We have a potential solution…
7. Its a Pathogen Party, and Everyone’s invited
It’s not just bacteria and fungus, it’s also other viruses especially the herpes family: HSV-1 & 2, and the Human Herpes Virus family (many) because it is so common (over 80% of population).
www.nature.com/articles/d41...
It’s not just bacteria and fungus, it’s also other viruses especially the herpes family: HSV-1 & 2, and the Human Herpes Virus family (many) because it is so common (over 80% of population).
www.nature.com/articles/d41...
Could long COVID be linked to herpes viruses? Early data offer a hint
Low cortisol levels and herpes-virus reactivation are associated with prolonged COVID-19 symptoms, preliminary research suggests. Low cortisol levels and herpes-virus reactivation are associated with ...
www.nature.com
February 7, 2024 at 5:48 PM
7. Its a Pathogen Party, and Everyone’s invited
It’s not just bacteria and fungus, it’s also other viruses especially the herpes family: HSV-1 & 2, and the Human Herpes Virus family (many) because it is so common (over 80% of population).
www.nature.com/articles/d41...
It’s not just bacteria and fungus, it’s also other viruses especially the herpes family: HSV-1 & 2, and the Human Herpes Virus family (many) because it is so common (over 80% of population).
www.nature.com/articles/d41...
6. The pathology of biofilm enabled SARS-CoV-2 Post Viral Syndrome in #LongCOVID is well studied in bats. The biofilm allow for the virus to evade the immune system, continue to evolve and fuels the growth of pathogenic fungus and bacteria.
journals.asm.org/doi/pdf/10.1...
journals.asm.org/doi/pdf/10.1...
journals.asm.org
February 7, 2024 at 5:47 PM
6. The pathology of biofilm enabled SARS-CoV-2 Post Viral Syndrome in #LongCOVID is well studied in bats. The biofilm allow for the virus to evade the immune system, continue to evolve and fuels the growth of pathogenic fungus and bacteria.
journals.asm.org/doi/pdf/10.1...
journals.asm.org/doi/pdf/10.1...
5. The biofilm theory of #LongCOVID and Post Viral Syndrome is by far the most evidenced and backed by science.
I’ll post a few good articles, including COVID but also others. This one is RSV - which is going around right now especially in children.
www.pnas.org/doi/10.1073/...
I’ll post a few good articles, including COVID but also others. This one is RSV - which is going around right now especially in children.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 7, 2024 at 5:46 PM
5. The biofilm theory of #LongCOVID and Post Viral Syndrome is by far the most evidenced and backed by science.
I’ll post a few good articles, including COVID but also others. This one is RSV - which is going around right now especially in children.
www.pnas.org/doi/10.1073/...
I’ll post a few good articles, including COVID but also others. This one is RSV - which is going around right now especially in children.
www.pnas.org/doi/10.1073/...
4. Cause
Once the virus weakens the immune system a polymicrobial invasion occurs. Bacteria and fungus invade and setup biofilms walls around their polymicrobial ecosystems that block the immune system.
www.ncbi.nlm.nih.gov/pmc/articles...
Once the virus weakens the immune system a polymicrobial invasion occurs. Bacteria and fungus invade and setup biofilms walls around their polymicrobial ecosystems that block the immune system.
www.ncbi.nlm.nih.gov/pmc/articles...
Polymicrobial Interactions: Impact on Pathogenesis and Human Disease
Summary: Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and o...
www.ncbi.nlm.nih.gov
February 7, 2024 at 5:45 PM
4. Cause
Once the virus weakens the immune system a polymicrobial invasion occurs. Bacteria and fungus invade and setup biofilms walls around their polymicrobial ecosystems that block the immune system.
www.ncbi.nlm.nih.gov/pmc/articles...
Once the virus weakens the immune system a polymicrobial invasion occurs. Bacteria and fungus invade and setup biofilms walls around their polymicrobial ecosystems that block the immune system.
www.ncbi.nlm.nih.gov/pmc/articles...