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Reposted by SellinLab

strategiska.se @strategiska.bsky.social · Sep 4

Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården.

#Organoid #UppsalaUniversitet #Forskning

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SellinLab @sellinlab.bsky.social · Aug 24

@eurjimmunol.bsky.social

SellinLab @sellinlab.bsky.social · Aug 24

With key contributions from Grisna Isabel Prensa and Julia Andersson, and made possible through our long-standing collaboration with the Pejler laboratory.

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SellinLab @sellinlab.bsky.social · Aug 24

Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek.

onlinelibrary.wiley.com/doi/10.1002/...

Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

Mast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-sec....

onlinelibrary.wiley.com

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SellinLab @sellinlab.bsky.social · Aug 5

Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines

www.nature.com/articles/s41...

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization - npj Vaccines

npj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

www.nature.com

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Victor J. Torres @torreslab.bsky.social · Jun 23

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Microbial Pathogenesis & Host Response

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

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SellinLab @sellinlab.bsky.social · Jun 24

Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo.

i3scongress.innozh.fr

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SellinLab @sellinlab.bsky.social · Jun 24

Congrats, @alexandraboegli.bsky.social !

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Nature Genetics @natgenet.nature.com · Jun 23

📢ONLINE @natgenet.nature.com

📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.

By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.

⬇️

www.nature.com/articles/s41...

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics

A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

www.nature.com

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SellinLab @sellinlab.bsky.social · Jun 24

@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.

Maria Letizia Di Martino @mldm.bsky.social · Jun 24

Excited to be at #EESMicrobiology this week presenting our latest work on #Shigella gut #organoid infection screen from our recent Nature Genetics paper (see below)!
Stop by poster 109 or just look for me, happy to chat and connect!
#Microbiology #Shigella #Organoids #TraDIS

Nature Genetics @natgenet.nature.com · Jun 23

📢ONLINE @natgenet.nature.com

📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.

By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.

⬇️

www.nature.com/articles/s41...

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Microbiology Society @microbiologysociety.org · Jun 16

The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25

Poster of Understanding and predicting microbial evolutionary dynamics 2025 saying that abstracts are closing. With the date of the event and location.

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Maria Letizia Di Martino @mldm.bsky.social · Jun 17

New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.

#Shigella #virulence #microsky

www.biorxiv.org

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SellinLab @sellinlab.bsky.social · Jun 13

Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday.

www.nature.com/articles/s41...

Organoid models advance dysentery control - Nature Genetics

Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...

www.nature.com

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SellinLab @sellinlab.bsky.social · Jun 12

Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com.

Link to the full paper here: rdcu.be/eqGgf

SciLifeLab @scilifelab.se · Jun 12

“we used mini organs, specifically mini-intestines, and infected them with a dangerous bacterium called Shigella” says @mldm.bsky.social‬

@sellinlab.bsky.social‬ (SciLifeLab & @uu.se) shows that cultured mini-organs can uncover how pathogens cause disease

youtu.be/xG_66ZGd_fk

Lab-grown mini-organs help uncover how pathogens cause disease

YouTube video by SciLifeLab

youtu.be

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SellinLab @sellinlab.bsky.social · Jun 12

The study would not have been possible without the relentless drive of @mldm.bsky.social and the very fruitful collaboration with Laura Jenniches and @lbarquist.bsky.social at the @helmholtz-hiri.bsky.social and many other colleagues. @andrenmateus.bsky.social, @erixoneriksson.bsky.social

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SellinLab @sellinlab.bsky.social · Jun 12

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.

Out @natgenet.nature.com:

rdcu.be/eqGgf

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen

Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...

rdcu.be

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Ferric Fang, MD @fangferric.bsky.social · Jun 11

I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.

NPR @npr.org · Jun 11

Despite its fishy name, the bacteria salmonella has no connection to the underwater creature.

Word of the Week: how a bacteria unrelated to fish got its name "salmonella"

Despite its fishy name, the bacteria salmonella has no connection to the underwater creature.

n.pr

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Jan-Willem Veening @veeninglab.com · Jun 10

New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...

DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM

wwwfbm.unil.ch

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Leigh Knodler @leighknodler.bsky.social · Jun 3

Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......

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European Research Council (ERC) @erc.europa.eu · Jun 2

Planning to apply for #research #funding from the ERC?

From the next application rounds, expect changes to the:

• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)

More 👇 europa.eu/!RPHWvv

Changes to the 2026 and 2027 Work Programmes

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

europa.eu

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SellinLab @sellinlab.bsky.social · May 30

With relevance also to epithelial #glycocalyx biology and #inflammasome signalling.

SellinLab @sellinlab.bsky.social · May 30

Kudos to first lead author Petra Geiser, and to all the contributors @uu.se, @scilifelab.se, Uppsala university hospital, @mldm.bsky.social @erixoneriksson.bsky.social

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SellinLab @sellinlab.bsky.social · May 30

The study highlights how just a handful of differing virulence factors active at the epithelial surface invasion step (Salmonella) vs at the intraepithelial expansion step (Shigella) to a large extent can explain the contrasting epithelial infection cycles of these related bacteria.

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SellinLab @sellinlab.bsky.social · May 30

Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.

journals.asm.org/doi/10.1128/...

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio

Pathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. This work combines ba...

journals.asm.org

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The LeibundGut-lab @lableibundgut.bsky.social · May 29

The LeibundGut-lab at the @mrccmm.bsky.social, in collaboration with @neil-gow.bsky.social, recruits two postdocs to study the skin commensal yeast Malassezia in atopic dermatitis #fungalrecognition and #fungalimmunology jobs.exeter.ac.uk/hrpr_webrecr... jobs.exeter.ac.uk/hrpr_webrecr...

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jobs.exeter.ac.uk

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