SellinLab
@sellinlab.bsky.social
The Mikael Sellin & colleagues infection biology laboratory at Uppsala University/SciLifeLab. MS responsible for posts.
Pinned
Reposted by SellinLab
Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen...
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
The pcnB gene sustains Shigella flexneri virulence
Author summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...
journals.plos.org
November 21, 2025 at 11:28 AM
Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen...
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
Reposted by SellinLab
Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården.
#Organoid #UppsalaUniversitet #Forskning
#Organoid #UppsalaUniversitet #Forskning
September 4, 2025 at 1:27 PM
Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården.
#Organoid #UppsalaUniversitet #Forskning
#Organoid #UppsalaUniversitet #Forskning
Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
Mast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-sec....
onlinelibrary.wiley.com
August 24, 2025 at 1:35 PM
Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization - npj Vaccines
npj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
www.nature.com
August 5, 2025 at 8:34 PM
Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by SellinLab
Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...
Microbial Pathogenesis & Host Response
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
June 23, 2025 at 8:24 PM
Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...
Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo.
i3scongress.innozh.fr
i3scongress.innozh.fr
June 24, 2025 at 11:54 AM
Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo.
i3scongress.innozh.fr
i3scongress.innozh.fr
Reposted by SellinLab
📢ONLINE @natgenet.nature.com
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics
A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.
www.nature.com
June 23, 2025 at 2:11 PM
📢ONLINE @natgenet.nature.com
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.
Excited to be at #EESMicrobiology this week presenting our latest work on #Shigella gut #organoid infection screen from our recent Nature Genetics paper (see below)!
Stop by poster 109 or just look for me, happy to chat and connect!
#Microbiology #Shigella #Organoids #TraDIS
Stop by poster 109 or just look for me, happy to chat and connect!
#Microbiology #Shigella #Organoids #TraDIS
📢ONLINE @natgenet.nature.com
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.
By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.
⬇️
www.nature.com/articles/s41...
June 24, 2025 at 8:58 AM
@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.
Reposted by SellinLab
The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25
June 16, 2025 at 3:00 PM
The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25
Reposted by SellinLab
New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
www.biorxiv.org
June 17, 2025 at 9:35 AM
New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Organoid models advance dysentery control - Nature Genetics
Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...
www.nature.com
June 13, 2025 at 11:13 AM
Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com.
Link to the full paper here: rdcu.be/eqGgf
Link to the full paper here: rdcu.be/eqGgf
“we used mini organs, specifically mini-intestines, and infected them with a dangerous bacterium called Shigella” says @mldm.bsky.social
@sellinlab.bsky.social (SciLifeLab & @uu.se) shows that cultured mini-organs can uncover how pathogens cause disease
youtu.be/xG_66ZGd_fk
@sellinlab.bsky.social (SciLifeLab & @uu.se) shows that cultured mini-organs can uncover how pathogens cause disease
youtu.be/xG_66ZGd_fk
Lab-grown mini-organs help uncover how pathogens cause disease
YouTube video by SciLifeLab
youtu.be
June 12, 2025 at 2:24 PM
Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com.
Link to the full paper here: rdcu.be/eqGgf
Link to the full paper here: rdcu.be/eqGgf
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
June 12, 2025 at 2:14 PM
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
Reposted by SellinLab
I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.
Despite its fishy name, the bacteria salmonella has no connection to the underwater creature.
Word of the Week: how a bacteria unrelated to fish got its name "salmonella"
Despite its fishy name, the bacteria salmonella has no connection to the underwater creature.
n.pr
June 11, 2025 at 4:01 PM
I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.
Reposted by SellinLab
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
wwwfbm.unil.ch
June 10, 2025 at 1:53 PM
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
Reposted by SellinLab
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
June 3, 2025 at 4:40 PM
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Reposted by SellinLab
Planning to apply for #research #funding from the ERC?
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
europa.eu
June 2, 2025 at 10:02 AM
Planning to apply for #research #funding from the ERC?
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio
Pathogenic bacteria employ partially overlapping sets of virulence factor functions
to colonize host epithelia but can differ markedly in their pathogenesis and disease
kinetics. This work combines ba...
journals.asm.org
May 30, 2025 at 1:45 PM
Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by SellinLab
The LeibundGut-lab at the @mrccmm.bsky.social, in collaboration with @neil-gow.bsky.social, recruits two postdocs to study the skin commensal yeast Malassezia in atopic dermatitis #fungalrecognition and #fungalimmunology jobs.exeter.ac.uk/hrpr_webrecr... jobs.exeter.ac.uk/hrpr_webrecr...
Powered by MHR
jobs.exeter.ac.uk
May 29, 2025 at 8:36 PM
The LeibundGut-lab at the @mrccmm.bsky.social, in collaboration with @neil-gow.bsky.social, recruits two postdocs to study the skin commensal yeast Malassezia in atopic dermatitis #fungalrecognition and #fungalimmunology jobs.exeter.ac.uk/hrpr_webrecr... jobs.exeter.ac.uk/hrpr_webrecr...
Reposted by SellinLab
Great meeting coming up next May
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
www.keystonesymposia.org
May 12, 2025 at 6:42 PM
Great meeting coming up next May
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by SellinLab
#EESInfection was very inspiring and enriching! Thanks for all new connections and for the opportunity to present our soon to be published story on TraDIShigella during infection of human intestinal organoids! Stay tuned to read the full story!
And it’s a wrap on #EESInfection! ✨🦠
Huge thanks to all participants, speakers, and organisers who made it a success. Can’t wait for next time!
🏅👏 Congrats to our 5 poster prize winners for their fantastic work!
Stay updated ➡️ embl.org/events/
Huge thanks to all participants, speakers, and organisers who made it a success. Can’t wait for next time!
🏅👏 Congrats to our 5 poster prize winners for their fantastic work!
Stay updated ➡️ embl.org/events/
May 28, 2025 at 2:55 PM
#EESInfection was very inspiring and enriching! Thanks for all new connections and for the opportunity to present our soon to be published story on TraDIShigella during infection of human intestinal organoids! Stay tuned to read the full story!
Reposted by SellinLab
The 23rd ESCMID Summer School is soon approaching! Claim your spot before it's too late! lnkd.in/dNJ67B6B
🛎️ Registration deadline extended to next week, 04 June 2025!
🗓️ 29 June - 05 July ☀️
🌍 University College Dublin, Ireland 🍀
#IDSky #MedSky #clinmicro
🛎️ Registration deadline extended to next week, 04 June 2025!
🗓️ 29 June - 05 July ☀️
🌍 University College Dublin, Ireland 🍀
#IDSky #MedSky #clinmicro
May 27, 2025 at 3:27 PM
The 23rd ESCMID Summer School is soon approaching! Claim your spot before it's too late! lnkd.in/dNJ67B6B
🛎️ Registration deadline extended to next week, 04 June 2025!
🗓️ 29 June - 05 July ☀️
🌍 University College Dublin, Ireland 🍀
#IDSky #MedSky #clinmicro
🛎️ Registration deadline extended to next week, 04 June 2025!
🗓️ 29 June - 05 July ☀️
🌍 University College Dublin, Ireland 🍀
#IDSky #MedSky #clinmicro
Reposted by SellinLab
Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04
Shigella, the first international meeting
coming-soon.embo.org
May 27, 2025 at 3:22 PM
Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04
Congrats to our newly baked Dr. Christopher von Beek, who defended his thesis on #Mastcells and #bacterial #infection in stride. Hooray!
Thanks a lot to faculty opponent Jean Marshall and committee members Sanna Koskiniemi, Cecilia Andersson and Stefan Roos for the high-level sparring.
Thanks a lot to faculty opponent Jean Marshall and committee members Sanna Koskiniemi, Cecilia Andersson and Stefan Roos for the high-level sparring.
May 25, 2025 at 9:29 PM
Congrats to our newly baked Dr. Christopher von Beek, who defended his thesis on #Mastcells and #bacterial #infection in stride. Hooray!
Thanks a lot to faculty opponent Jean Marshall and committee members Sanna Koskiniemi, Cecilia Andersson and Stefan Roos for the high-level sparring.
Thanks a lot to faculty opponent Jean Marshall and committee members Sanna Koskiniemi, Cecilia Andersson and Stefan Roos for the high-level sparring.