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Background The study aims to understand system barriers to research participation for people with intellectual disabilities. Methods A mixed-methods approach examined the inclusivity of people wit...

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This cross-sectional study examines the inclusion of patients with cancer from lower and upper middle–income countries in randomized clinical trials conducted by high-income countries.

A new campaign at UCC aims to make health research more inclusive, to include under-served groups like women, ethnic minorities, LGBTQ+ individuals, older adults, and people with disabilities

This link will take you to a page that’s not on LinkedIn

This link will take you to a page that’s not on LinkedIn

Abstract. The burden of heart failure remains substantial worldwide, and heart failure with reduced ejection fraction (HFrEF) affects approximately half of

Background Cancer clinical trials often employ exclusion criteria that can impact vulnerable populations, particularly individuals with psychological, psychiatric, or neurological conditions. Aims...

PDF | On Apr 23, 2019, Sean Khozin and others published Decentralized Trials in the Age of Real‐World Evidence and Inclusivity in Clinical Investigations | Find, read and cite all the research you nee...

Background The importance of more diversity of study populations in clinical trials is currently widely acknowledged. Decentralized clinical trial (DCT) approaches are presented as a potential means to broaden diversity by eliminating several barriers to participation. However, the precise meaning of, and objectives related to diversity in DCTs remain unclear. Diversity runs the risk of becoming a ‘buzzword’: widely acknowledged to be important, yet prone to multiple interpretations and challenging to implement in practice. We argue that the aim of increasing diversity in clinical trials requires clear and well-substantiated specifications. Methods We analyze the concept of diversity and the ethical requirements surrounding fair participant selection within the context of clinical research, in order to further specify and operationalize the aim of increasing diversity in the context of DCTs. Results Through analyzing the concept of diversity and ethical requirements for fair participant selection, we propose that diversity should be specified in a way that improves the position of the groups that are currently most underrepresented in the research context. In practice, this entails that, in order to contribute to diversity, the selection of participants should prioritize (i) gaining scientific knowledge on groups for which this is lacking, and (ii) inclusion of underrepresented groups in research when appropriate considering a study’s objectives, and risks and benefits. Conclusions Our analysis facilitates translating the aim of increasing diversity with DCTs to more specific and actionable objectives for recruitment and inclusion. Moreover, it contributes to a further specification of the concept of diversity and fair participant selection in research contexts.

Background Patient and public involvement (PPI) in research is growing internationally, but little is known about black and minority ethnic (BME) involvement and the factors influencing their involv...

Health equity should be regarded as a fundamental principle and a priority for all guideline development organizations. Yet, this principle has not been consistently prioritized in the creation of ma...

Improving diversity in clinical trials is an ethical and scientific imperative, which requires a multifaceted approach.

Background Representing all population groups in health and social care research is essential for generating research relevant to decision making in everyday clinical and social healthcare policy and ...

Public involvement in research and other initiatives for myalgic encephalomyelitis (ME) (also known as chronic fatigue syndrome) has been crucial in raising awareness of the disease and exposing inad...