Lightnews — Scholar-powered news

Reposted by Shady Saad

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

10 46 120

Shady Saad @shadys11.bsky.social · 7d

Fantastic work Raquel! So well deserved

1

Shady Saad @shadys11.bsky.social · 22d

I’m very excited to share that Stanford Medicine has highlighted my work

med.stanford.edu/news/insight...

Behind the Science: How a ‘speech gene’ could help treat Huntington’s

Stanford Medicine researchers found cells that keep a speech-linked protein called FOXP2 from clumping; its tricks could break apart clumps of proteins that cause devastating brain diseases.

med.stanford.edu

7

Reposted by Shady Saad

Ryan Flynn @raflynn5.bsky.social · Apr 23

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically

connecting ‘cell surface RNA biology’ to cancer biology

@natbiotech.nature.com
www.nature.com/articles/s41...

3 22 65

Reposted by Shady Saad

Cedric Boeckx @cedricboeckx.bsky.social · Apr 22

What did the two amino acid substitutions in #FOXP2 that occurred uniquely in the human lineage do? 🧪🧬 🧠
Fascinating new @cp-cell.bsky.social study by @shadys11.bsky.social D. Jarosz & J. Wysocka, uncovering a molecular function for these 2 substitutions in promoting the solubility of FOXP2. (1/n)

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

www.cell.com

2 12 26

Reposted by Shady Saad

Simon Fisher @profsimonfisher.bsky.social · Apr 22

When we first isolated FOXP2 & implicated it in speech disorder, a notable feature was its big stretch of consecutive glutamine (Q) residues, the longest polyQ tract in a native protein. @shadys11.bsky.social et al here use it as a model to reveal how polyQ proteins avoid forming toxic assemblies.🙌🧪

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

www.cell.com

3 8 23

Shady Saad @shadys11.bsky.social · Apr 22

To our surprise, there is more contribution for the N303 site on the solubility of FOXP2.
The same site is also contributing more to certain humanized mouse phenotypes

www.nature.com/articles/s41...

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein - Scientific Reports

Scientific Reports - Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

www.nature.com

1 1

Shady Saad @shadys11.bsky.social · Apr 22

Thank you!

1

Shady Saad @shadys11.bsky.social · Apr 22

Thank you Christa!!

Shady Saad @shadys11.bsky.social · Apr 21

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social

www.cell.com/cell/fulltex...

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

www.cell.com

3 23 100

Reposted by Shady Saad

Cell - a Cell Press journal @cp-cell.bsky.social · Apr 16

Now online! DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-promoting mechanisms utilized by FOXP2 diminishes aggregation and amyloid formation by the pathological form of Huntingtin polyQ.

dlvr.it

2 3