Shan-Lu Liu
@shanluliu.bsky.social
1.3K followers 160 following 22 posts
President, American Society for Virology; Professor, The Ohio State University
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shanluliu.bsky.social
We are excited to share our new work on PLSCR1 restriction of entry of HIV and other lentiviruses published now in PNAS www.pnas.org/doi/epdf/10....
shanluliu.bsky.social
May be related to the increased conformational stability of spike induced by these NTD mutations, correlating with decreased fusion and infectivity journals.asm.org/doi/full/10....
Reposted by Shan-Lu Liu
gregggonsalves.bsky.social
I wanted to remind everyone about the "Save AIDS Research" livestream that will go live on YouTube this Tuesday (9/16) at 11:00am EDT. We have an amazing program of 70+ speakers who will be sharing their latest research. Get all the details at www.saveaidsresearch.org.
24 Hours to Save AIDS Research
www.saveaidsresearch.org
shanluliu.bsky.social
We mourn the passing of Nobel laureate David Baltimore, a towering figure in molecular biology and virology, and a pioneer and founder of ASV. His discoveries transformed science and medicine, and his mentorship inspired generations. His legacy will continue to guide and inspire virology and ASV.
Reposted by Shan-Lu Liu
amersocvirology.bsky.social
As RFK testifies in front of the Senate today, ASV wants to emphasize the risks posed by his decisions related to virus outbreaks and the public health of Americans. Together with our partner organizations, we call for RFK's resignation: asm.org/press-releas...
Joint Statement Calling for Secretary Kennedy Resignation
The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.
asm.org
shanluliu.bsky.social
An incredible episode: Stanley Plotkin joins TWiV to recount his career as a vaccinologist, having participated in the development of vaccines for polio, rabies, and rubella, and his thoughts on the current anti-science, anti-public health, and anti-vaccine climate. www.microbe.tv/twiv/
shanluliu.bsky.social
Years of research show protection from COVID-19 vaccines — both the types made with mRNA and a type made with traditional technology — does wane over time. The vaccinations provide the strongest protection against severe infection and death, even if people still become infected.
shanluliu.bsky.social
I am honored to serve as president of the American society for Virology, thank you for your support. I wish to thank our past president Hector Aguilar-Carreno for a wonderful service and look forward to working with everyone.
shanluliu.bsky.social
Harvard Virologist David Knipe on his NIH grant cancellation: “How did forty-five years of desired research become undesirable overnight?” magazine.hms.harvard.edu/articles/i-a...
Reposted by Shan-Lu Liu
zandrea.bsky.social
A wonderful talk by @shanluliu.bsky.social at #ASV2025 about viral cell-cell transmission. Thank you for the shout out to our deltaE SARS-CoV-2 preprint!
A slide from Dr. Shan-Lu Liu’s symposium at ASV 2025 showing figures from my postdoc Dr. Hannah Fischer’s preprint on deltaE SARS-CoV-2.
shanluliu.bsky.social
Congratulations to Michael and also Harmit! Hutch is indeed a unique place. I learned a lot from the Thursday morning virology meeting and truly enjoyed the Friday afternoon seminars and beer hours.
Reposted by Shan-Lu Liu
biorxivpreprint.bsky.social
IFN-inducible Human Phospholipid Scramblase 1 (PLSCR1) ProteinRestricts HIV-1 Infection by Inhibiting Membrane Fusion https://www.biorxiv.org/content/10.1101/2025.06.23.661195v1
shanluliu.bsky.social
Our new work: ZIKV infection induces autophagy which mediates the downregulation of host entry factors TIM-1 and AXL. This, in turn, promotes sustained ZIKV infection by preventing superinfection and dampening the host innate immunity. www.pnas.org/doi/10.1073/...
shanluliu.bsky.social
Hi Michael, sorry missing the party due to travels, congratulations on your retirement! Thank you for your support of me and scientific community.
shanluliu.bsky.social
The ancestral BA.3 was much less immune evasive compared to BA.1 and BA.2, see our NEJM paper in 2022 www.nejm.org/doi/10.1056/...
shanluliu.bsky.social
BA.2.87.1 is quite different from JN.1 and XBB.1.5 but more similar to their ancestral BA.2 in infectivity and neutralization escape. journals.asm.org/doi/10.1128/...
Reposted by Shan-Lu Liu
Reposted by Shan-Lu Liu
amersocvirology.bsky.social
Vaccines work! As measles cases have recently been reported in Alaska, Georgia, New York, Rhode Island and Texas, it's important to remember that prior to the introduction of the measles vaccine in 1963, measles killed 400-500 people and resulted in ~48,000 hospitalizations per year.
Graph showing that prior to 1963 when the measles vaccine was introduced, there were around 300,000-700,000 measles cases per year. Within a few years of the vaccine, the number of cases fell below 20,000/year. There were a blips where cases rose, but shortly after the second vaccine dose was recommended in 1989, annual cases have generally been well below 1,000 cases. In 2000, measles elimination was declared in the US. Now we have sporadic outbreaks that typically spread among unvaccinated people. Chart is from Center for American Progress and is based on CDC data on measles cases.