Sharu Paul
sharupaul.bsky.social
Sharu Paul
@sharupaul.bsky.social
Scientist @ISU

Bioinformatics | Deep Learning | Single Cell Tech
Reposted by Sharu Paul
Apomixis in Boechera isn't a quirk—it’s driven by fragile genomic sites, B chromosomes, and chromosome fissions.

Key takeaway: Evolution is reusing these fragile regions repeatedly to trigger apomixis. Not just dosage, but structural evolution! #PlantSci #Evolution #Genetics #PAG33
January 9, 2026 at 7:42 PM
Reposted by Sharu Paul
Legumes usually fix nitrogen in their roots, but Sesbania rostrata does it in the stem. Haofei Luo used EMS to find that ARP1 is a key transcription factor, and when overexpressed, can induce stem nodule-like structures in a relates species. #PlantSci #Legumes #Symbiosis #PAG33
January 9, 2026 at 9:34 PM
Reposted by Sharu Paul
For example, you shouldn't use a splice-aware RNA-Seq aligner like STAR on reads from a prokaryotic organism. 🧬 🖥️ #PAG33

I think this is why it can be challenging to teach bioinformatics. There is so much knowledge that needs to be taught!

What other examples can you think of?
December 15, 2025 at 3:09 PM
Reposted by Sharu Paul
Bioinformatics rests on three pillars of knowledge: Biology, Sequencing Technology and Software. Not understanding the assumptions and limitations of these pillars as they relate to your project will reduce your ability to explore your data. 🧬 🖥️ #PAG33
December 15, 2025 at 3:06 PM
Reposted by Sharu Paul
Agata Daszkowska-Golec highlights a "genetic flip" where removing two components of the cap-binding complex (CBC) actually creates hormone insensitivity though single mutants are highly sensitive. CBC loss disturbs the spliceosome and interacts with SERRATE (SE) to alter mRNA metabolism. #PAG33
January 9, 2026 at 10:09 PM
Reposted by Sharu Paul
Kevin Cox presented Expansion Microscopy: using a swellable hydrogel to enlarge cells physically moving cellular structures apart, allowing nanoscale imaging on a standard light microscope. I wonder if this can translate to better chromosome squashes? #Microscopy #Jim_Birchler #PAG33
January 9, 2026 at 10:32 PM
Reposted by Sharu Paul
🧊 Postdoctoral Researcher – University of Oslo, Norway
Advance AI-powered Arctic observing systems using data from field & satellite sources
🎓 PhD in #Geosciences or related field
📅 Deadline: 5 Dec 2025
🔗 higherjobz.com/postdoctoral...
#Postdoc #Research #ArcticResearch #Norway #AcademicJobs
Postdoctoral Researcher in Arctic Observing Systems – Oslo | HigherJobz
Apply for a Postdoctoral Researcher position in Active Learning for Arctic Observing Systems at the University of Oslo. Deadline 5 Dec 2025.
higherjobz.com
November 2, 2025 at 5:05 AM
Reposted by Sharu Paul
Reposted by Sharu Paul
My department is hiring! Join us! jobs.colostate.edu/postings/165...
September 8, 2025 at 7:41 PM
Reposted by Sharu Paul
The NIH Loan Repayment program is ongoing. NIH will repay 25% of eligible education debt, up to a max of $50,000/ yr for individuals qualified by higher degree status and US citizen, national, or resident status.
Eligibility, subcategories&application guide/link:
grants.nih.gov/funding/fund...
Extramural LRP | Grants & Funding
grants.nih.gov
September 9, 2025 at 12:16 PM
Reposted by Sharu Paul
In a global first, Uganda’s Ministry of Health, the World Health Organization (WHO) and other partners today launched a first-ever vaccine trial for Ebola from the Sudan species of the virus, and at an unprecedented speed for a randomized vaccine trial in an emergency.🧵
February 3, 2025 at 9:22 PM
Reposted by Sharu Paul
RIP blood brain barrier & brain trauma grants
February 4, 2025 at 2:18 AM
Reposted by Sharu Paul
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 1:26 AM
Reposted by Sharu Paul
The soybean cyst nematode genomics database has been updated as of last night. SCNBase.org now has all 9 early release H. glycines genomes and annotations. All files are downloadable and accessible through BLAST, feature search, and Jbrowse. The pan-genome paper is coming soon! #science #genomics
SCNBase
SCNBase.org
November 27, 2024 at 6:08 PM
Turkeys have 80 chromosomes. Humans have 46. We don't know the biological significance of the chromosome numbers. All we know is changing the number changes the biology.
November 26, 2024 at 11:28 PM
Unlike XX/XY in Humans, Birds have ZZ/ZW system. There's more, males are homogametic ZZ, and females are heterogametic ZW.
November 26, 2024 at 11:13 PM
Whales are more closely related to cows than cows are to horses
November 14, 2024 at 2:17 AM