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SheinerLab @sheinerlab.bsky.social · 1d

An official new measuring unit for the parasitology community had emerged from this @parafrap.bsky.social #EMBO conference... #shitton @nicolas3474.bsky.social
@kirkdeitsch.bsky.social

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SheinerLab @sheinerlab.bsky.social · 2d

Fabulous work from @nicolas3474.bsky.social on the protein atlas of the molluscs parasite #Perkinsus @parafrap.bsky.social

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SheinerLab @sheinerlab.bsky.social · 2d

Wonderful session on @parafrap.bsky.social parasites pathogenesis chaired by @apicolipid.bsky.social @clarehardinglab.bsky.social

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SheinerLab @sheinerlab.bsky.social · 2d

The science at #ParaFrap is exciting and surprising as always - less surprising: who are the last people standing on night #1 ... @freddyfrischknecht.bsky.social @kirkdeitsch.bsky.social

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SheinerLab @sheinerlab.bsky.social · 2d

Kick-off of @parafrap.bsky.social #EMBO conference at #LesEmbiez by the wonderful organisers @gloverlab.bsky.social and Benoit Gamain who put together an exciting program about parasite biology, epidemiology and combat.

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SheinerLab @sheinerlab.bsky.social · 8d

We have a project advertised as part of the @NorthWestBio1 program this year - come join us!

www.gla.ac.uk/postgraduate...

Applications to the program are here:
www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Lilach Sheiner

www.gla.ac.uk

SheinerLab @sheinerlab.bsky.social · 13d

Congratulations Saniya for graduating her PhD!!!

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SheinerLab @sheinerlab.bsky.social · 20d

Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki)

www.jobs.gla.ac.uk/job/research...

Research Associate

Job PurposeThe purpose of this role is to carry out cutting-edge research to understand the structure and function of complexes essential for organelle biology and function in the apicomplexan para...

www.jobs.gla.ac.uk

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Reposted by SheinerLab

André Schneider, University of Bern @schneian.bsky.social · 28d

The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex

Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...

journals.plos.org

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SheinerLab @sheinerlab.bsky.social · Jun 26

Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how they function in the context of each organisms’ specialised needs.

SheinerLab @sheinerlab.bsky.social · Jun 24

Team bioenergetics in divergent organisms is ready to go! #ICOP25 @macleanlab.bsky.social @lettsscience.bsky.social

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SheinerLab @sheinerlab.bsky.social · Jun 24

@fad1.bsky.social showing us how gene drives will end malaria!!

SheinerLab @sheinerlab.bsky.social · Jun 24

A first #ICOP25 day 2 highlight: Dayana Salas-Leiva of Ross Waller's lab uses LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!

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SheinerLab @sheinerlab.bsky.social · Jun 23

Some great models used to study endosymbiosis and what does it take to make a stable relationship:

Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions

Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis

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SheinerLab @sheinerlab.bsky.social · Jun 23

First - a vivid discussion about determining the origin and early evolution of eukaryotes following Andrew Roger's talk.

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SheinerLab @sheinerlab.bsky.social · Jun 23

#ICOP25 opened today with so many exciting eukaryotic microbe insights 🦠 - you know its gonna be a great one when it starts with a drown video 😉 Stay tuned!!

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Reposted by SheinerLab

Shikha @shikhas.bsky.social · May 19

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇

Andrew Maclean @macleanlab.bsky.social · May 19

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

www.nature.com

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Reposted by SheinerLab

Andrew Maclean @macleanlab.bsky.social · May 19

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

www.nature.com

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SheinerLab @sheinerlab.bsky.social · May 19

Other complex III inhibitors are being developed as drug leads for apicomplexan diseases.
Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.

SheinerLab @sheinerlab.bsky.social · May 19

Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown.
We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.

SheinerLab @sheinerlab.bsky.social · May 19

Respiratory complexes form “super-complexes” whose physiological function is debated, and assembly only studied in a few organisms.
We showed that apicomplexan conserved proteins mediate III2-IV supercomplex formation, and that this provides competitive growth advantage.

SheinerLab @sheinerlab.bsky.social · May 19

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!

But how do the parasite complexes work and how do drugs inhibit them?

Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Andrew Maclean @macleanlab.bsky.social · May 19

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

www.nature.com

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SheinerLab @sheinerlab.bsky.social · Apr 25

Inspirational talk from Dr Sharifa Abdulla about how to strike partnerships - think:
What is the problem
Whose problem is it (and therefore)
Who should be engaged in the partnership

SheinerLab @sheinerlab.bsky.social · Apr 25

Excellent to take part in a round table focus on African partnerships within our Glasgow Changing Futures strategy
@uofgsii.bsky.social @uofglasgow.bsky.social

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SheinerLab @sheinerlab.bsky.social · Mar 31

As Sheinerlab is joining the trend, Chat seem to have known that @macleanlab.bsky.social started his own lab recently and took the executive decision to remove him from the photo 😲😆

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