Shizhong Dai
@shizhong-dai.bsky.social
Chemical biology enthusiast
NCI K99/R00, Schmidt Science Fellow w/Alice Ting
PhD w/ Kevan Shokat
NCI K99/R00, Schmidt Science Fellow w/Alice Ting
PhD w/ Kevan Shokat
Check out this cool project led by Peter/Andrew in the Ting lab! Amazing how a simple, elegant computational method can reveal mutation-biased conformational preferences in some of my fav proteins. Excited to be part of this and to see CB expanded to many other protein families!
Can we design mutations that bias proteins towards desired conformational states?
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
www.science.org
January 9, 2026 at 6:29 PM
Check out this cool project led by Peter/Andrew in the Ting lab! Amazing how a simple, elegant computational method can reveal mutation-biased conformational preferences in some of my fav proteins. Excited to be part of this and to see CB expanded to many other protein families!
Reposted by Shizhong Dai
Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: www.huttenhainlab.com
By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/...
#TeamMassSpec
By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/...
#TeamMassSpec
Huttenhain Lab | Home
The Huttenhain Lab at Stanford University studies cellular signaling networks to uncover how cells decode extracellular cues into dynamic physiologic responses.
www.huttenhainlab.com
December 6, 2024 at 3:03 PM
Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: www.huttenhainlab.com
By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/...
#TeamMassSpec
By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/...
#TeamMassSpec
Reposted by Shizhong Dai
So excited to share our work developing a new class of modular synthetic GPCRs, out today @Nature! Check it out nature.com/articles/s41...
December 5, 2024 at 8:10 AM
So excited to share our work developing a new class of modular synthetic GPCRs, out today @Nature! Check it out nature.com/articles/s41...
Reposted by Shizhong Dai
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..