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@sigellab.bsky.social

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Student-run account of the SigelLab. We love RNA, smFRET and NMR! In our lab, we determine structures and study dynamics of "active" RNAs. These active RNAs perform a function, e.g. self-cleavage or influencing gene expression.

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sigellab.bsky.social @sigellab.bsky.social · Jun 5

By the way: here's the beautiful cover picture!

sigellab.bsky.social @sigellab.bsky.social · Jun 5

There's a joint spotlight collection on Bioinorganic Chemistry between Chemical Science and Dalton Transactions - and our paper on elucidating the structure of G4 quadruplexes (pubs.rsc.org/doi/D5SC01416F) has been selected!

Check out the entire collection here: rsc.li/bioinorganic...

Spotlight Collection: Bioinorganic Chemistry Home

pubs.rsc.org

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sigellab.bsky.social @sigellab.bsky.social · Apr 15

Congratulations to Matteo Lisibach for winning the Semesterpreis of the University of Zurich for his outstanding master thesis entitled "Toward multiple coordinates: Resolving the intrinsic heterogeneity of a group II intron folding and splicing process". Very well done Matteo!

A folded RNA molecule in the confocal volume of a microscope and a graph showing excitations in the Cy3 and Cy5 channel. Expanding the single-molecule FRET toolkit to tackle complex macromolecular dynamics.

sigellab.bsky.social @sigellab.bsky.social · Apr 7

Do you want to assign solution structures of G-quadruplexes using NMR? Maybe this new approach we just published works for you. Congrats to Zhenghui and Carla for this amazing work!

doi.org/10.1039/D5SC01416F

Elucidating the solution structure of the monomolecular BCL2 RNA G-quadruplex: a new robust NMR assignment approach

5′ untranslated regions (UTRs) of mRNA commonly feature G-quadruplexes (G4s), crucial for translational regulation and promising as drug targets to modulate gene expression. While NMR spectroscopy is ...

doi.org

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sigellab.bsky.social @sigellab.bsky.social · Mar 13

And this is why we do RNA research. Credit: The incredible xkcd. xkcd.com/3056/

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sigellab.bsky.social @sigellab.bsky.social · Feb 26

Our collaborative work titled "G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs" was selected for the Inorganic Chemistry Frontiers Outstanding Papers Award! Thanks to everyone who has participated in this outstanding work!

sigellab.bsky.social @sigellab.bsky.social · Feb 25

Hello bluesky! The SigelLab is now also here, we are looking forward to good science, fascinating stories and good discussions!

This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.

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