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Simon Grassmann 草人 @simongrassmann.bsky.social · May 23

I didn't expect to be so sad learning that my favorite philosopher, Alasdair MacIntyre, has passed 💔. I hope I can explore lessons from his philosophy for STEM research more in the future, I made a first attempt in this book chapter:

sciencedirect.com/science/arti...

Neoliberalism in academia—What we can learn from physiology

Neoliberalism has transformed academia by centering competition. Competition for high-impact papers and grants is supposed to “optimize” science. Howe…

sciencedirect.com

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Reposted by Simon Grassmann 草人

Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 21

So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus

During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

www.science.org

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Simon Grassmann 草人 @simongrassmann.bsky.social · Mar 7

Traveled to DC today for the Stand Up for Science rally ❤️🔬
We need public funding of science, no cuts!

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Reposted by Simon Grassmann 草人

Joseph Sun Lab @josephsunlab.bsky.social · Feb 28

Congratulations to Dr. Adriana Mujal on this @cp-immunity.bsky.social study demonstrating a new role for an age old cytokine! www.cell.com/immunity/ful...

Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells

NK cells possess innate and adaptive features, but unlike T and B cells, NK cells are not thought to require priming in lymphoid organs. Mujal et al. demonstrate that the spleen supports enhanced expa...

www.cell.com

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Reposted by Simon Grassmann 草人

Romagnani Lab @romagnanilab.bsky.social · Dec 3

Huge congratulations to @timorckert.bsky.social on receiving the Pettenkofer Prize for our work on human NK cell memory and clonality! A heartfelt thank you to Oliver Keppler and the Pettenkofer-Stiftung for the warm welcome and the wonderful ceremony!

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Simon Grassmann 草人 @simongrassmann.bsky.social · Dec 3

Not sure who can access this outside US universities.. 😬 will try to write articles about the topic soon

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Simon Grassmann 草人 @simongrassmann.bsky.social · Dec 3

I made an excursion into the Humboldt vs. neoliberal university model, some (left) Alasdair MacIntyre takes on virtues in academia and ideas about what to change and how. 😉 Check out my chapter about neoliberalism in academia in this new book: www.sciencedirect.com/science/arti...

Neoliberalism in academia—What we can learn from physiology

Neoliberalism has transformed academia by centering competition. Competition for high-impact papers and grants is supposed to “optimize” science. Howe…

www.sciencedirect.com

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 18

You should follow my amazing mentor joe 😊 we have a lot cooking in the lab about to go out, if you are interested in NK cells (and a little CD8 and even B cells 😂) give a follow

Joseph Sun Lab @josephsunlab.bsky.social · Nov 18

hello to everyone on bluesky!

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Reposted by Simon Grassmann 草人

Joseph Sun Lab @josephsunlab.bsky.social · Nov 18

hello to everyone on bluesky!

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 16

Immunologists (especially if interested in NK cells) should follow @labwaggoner.bsky.social, on twitter the best way to not miss papers 😅 stephen you should ask @rodrahimi.bsky.social to be added to an “immunology starter pack”

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 14

This is amazing 😊 could you add me too?

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 13

Now I study NK cell signaling, in particular antigen and cytokine signaling via STATs. I put something on BioRxiv, but it changed a lot, when I resubmit I will adapt it. Hit me up if you need help with STAT CUT&RUNs, I have established them all (but STAT6 😅)

www.biorxiv.org/content/10.1...

Early antigen receptor signaling in natural killer cells alters STAT4-dependent fate decisions via epigenetic remodeling

Natural Killer (NK) cells are innate cytotoxic lymphocytes that possess features of adaptive immunity, including antigen specificity and clonal expansion. NK cells rapidly respond to cytokines release...

www.biorxiv.org

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 13

ILC1-like NK cells as separate lineage:

www.cell.com/immunity/ful...

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Adaptive-like responses to MCMV are thought to originate from circulating conventional NK cells. Here, Flommersfeld et al. use single-cell fate mapping to show that a separate lineage of spleen-reside...

www.cell.com

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 13

NK cells first single-cell transfer:
www.cell.com/immunity/ful...

www.cell.com

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Simon Grassmann 草人 @simongrassmann.bsky.social · Nov 13

To populate my Bluesky and people know what I do: I am an MD turned immunology "basic" researcher. In the past I did adoptive T cell therapy and then fate mapping in the Buchholz lab in Munich:
CD8+ T cells in MCMV:
www.nature.com/articles/s41...

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection - Nature Immunology

T cell memory formation is often described as occurring during the chronic phases of infection. Buchholz and colleagues use the phenomenon of ‘memory inflation’ following cytomegalovirus infection to ...

www.nature.com

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