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Andrea Sinz 🧪

@sinzandrea.bsky.social

1.2K followers 1.2K following 200 posts

Full (W3) Professor Pharm. Chem. & Bioanalytics at MLU Halle-Wittenberg; Center for Structural Mass Spectrometry https://agsinz.pharmazie.uni-halle.de https://rtg2467.uni-halle.de/ #teammassspec #massspec #ChemSky Structural proteomics, cross-linking MS

agsinz.pharmazie.uni-halle.de

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 18d

‼️ Our Nature Comm paper is finally online!🎉
pubmed.ncbi.nlm.nih.gov/40973726/
I am so proud of this joint work with Anette Kaiser @unileipzig.bsky.social. We investigate the interactions of the Y2 receptor with NPY. Thank you all who contributed! 👏 💪
@unihalle.bsky.social #chemsky #academicsky

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 12h

🧪What a fantastic symposium with such amazing science! Thank you 🙏 Andrea Graziadei, @claudio-iacobucci.bsky.social and Lolita Piersimoni, for getting this organized!🎉🎉🎉
@humantechnopole.bsky.social
Next year this symposium will be held in San Francisco…
#teammassspec #academicsky #chemsky

Andrea Sinz 🧪 @sinzandrea.bsky.social · 1d

🧪 Michal Sharon just gave a fantastic talk @ssp2025.bsky.social on how native MS can give detailed structural insights into the circulating 20S proteasome. 👏 @humantechnopole.bsky.social #teammassspec #academicsky

Andrea Sinz 🧪 @sinzandrea.bsky.social · 2d

🧪 Paola Picottigives a great keynote lecture on decoding the protein dance. What a fantastic first day of the @ssp2025.bsky.social at @humantechnopole.bsky.social in Milan!👏

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 3d

🧪
www.nature.com/articles/s41...

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 3d

🧪 And this is the second Nature Communications @natcomms.nature.com paper where we contributed:
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social

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Reposted by Andrea Sinz 🧪

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 21d

New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴

doi.org/10.48550/arX...

Figure 3 from the paper with the caption: "Role of machine learning in de novo design of IDRs. (A) Machine-learning models can be trained on diverse data sources, from molecular dynamics simulations to annotations of cellular localization and protein structures from the Protein Data Bank. (B) Often implemented as neural networks using sequence-encoded features as input, these models can initially be trained on a limited region of sequence space as surrogate models. Through active learning, additional simulations are performed during the design campaign to generate new data, and the surrogate model is retrained on the expanded dataset to progressively improve its accuracy. (C) Machine-learning models have been developed to predict biophysical observables, biological annotations, and protein structures. When combined, machine-learning models can be used to identify a set of sequences that strike a trade-off between multiple design objectives, defining a Pareto front."

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 18d

🧪This works impressively demonstrates the power of integrated approaches to gain important structural insights into GPCRs. XL-MS, biochemical assays, and MD simulations were combined in this study.
#pharmsky #chemsky #GPCR

Andrea Sinz 🧪 @sinzandrea.bsky.social · 18d

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Reposted by Andrea Sinz 🧪

Barack Obama @barackobama.bsky.social · 20d

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

Let’s be clear about what happened to Jimmy Kimmel

Trump’s most brazen attack on free speech yet.

www.yahoo.com

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 18d

I absolutely love the Sagrada Familia; it is breathtaking. 🥰

Andrea Sinz 🧪 @sinzandrea.bsky.social · 22d

#PhD

Andrea Sinz 🧪 @sinzandrea.bsky.social · 22d

Actually, Alessio has two twins! Look at the picture: one is a real twin, the other one is not…can you tell who is who???😂😂😂

Andrea Sinz 🧪 @sinzandrea.bsky.social · 22d

Alessio Di Ianni from our group just defended his thesis on studying intrinsically disordered proteins by XL-MS. Bravo!🎉🎉 Fantastic defense and discussion! 👏 #proudPI @unihalle.bsky.social @humantechnopole.bsky.social #RTG2467 #Academicsky #pharmsky #chemsky

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 25d

This publication also counts for our SFB1664! 😁@snp2prot.bsky.social @unihalle.bsky.social @ipbhalle.bsky.social

Andrea Sinz 🧪 @sinzandrea.bsky.social · 25d

😂

Andrea Sinz 🧪 @sinzandrea.bsky.social · 25d

Third Nature Comm paper accepted within two weeks…I have never had this before…😜

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 25d

Suche dir so früh wie möglich gute und erfahrene Mentor*innen! Netzwerke von Frauen in der Wissenschaft sind extrem wichtig. @femalesinms.bsky.social

Bluesky

sofemalesinms.bsky.social

Andrea Sinz 🧪 @sinzandrea.bsky.social · 25d

Our manuscript "Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport" has just been accepted at Nature Communications!🎉🎉 I feel truly honored to be part of this work that was headed by Panos Kastritis and Gary Sawers.More information to follow! @unihalle.bsky.social
#Academicsky

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Reposted by Andrea Sinz 🧪

Jon Kenna @jonkenna.bsky.social · 26d

Green Chair Blue Chair
by me
#photography #streetphotography

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Reposted by Andrea Sinz 🧪

Biophysical Society @biophysicalsoc.bsky.social · Sep 4

Submit your abstract for "Understanding Peripheral Membrane-Protein Interactions: Structure, Dynamics, Function and Therapy," a BPS Thematic Meeting in Thessaloniki, Greece from November 9-13, 2025

Abstract deadline is September 15

2025 Greece Thematic Meeting | Biophysical Society

The monthly newsletter for BPS members and friends.

buff.ly

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 26d

@shimadzuuk.bsky.social Welcome!🧪
As the new semester will start soon our pharmacy students @unihalle.bsky.social will have the chance to use our new tiny MALDI-MS for identifying proteins.💊🦠🧫🧪 #academicsky #chemsky #pharmsky

Andrea Sinz 🧪 @sinzandrea.bsky.social · Jun 12

Our new tiny MALDI-8030 Easy Care has just arrived…first Shimadzu MS in my life…😜 We will use it for biotyping 🦠 and for teaching our pharmacy students. 💊🧬🧪 @unihalle.bsky.social
#AcademicSky
#ChemSky

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 26d

I brought the mug (SArCaSm) back from the #BMSS2025 in Edinburgh as gift for my lab @unihalle.bsky.social and they absolutely love it!😍

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 26d

Great idea to move here!😊

Reposted by Andrea Sinz 🧪

Ralf Reski @reskilab.bsky.social · 27d

Professorship Plant Genetics. Würzburg, Germany.
#plantscijobs #plantscijob
www.academics.de/jobs/univers...

Universitätsprofessorin / Universitätsprofessor (m/w/d) für Pflanzengenetik (W3) - Julius-Maximilians-Universität Würzburg

Julius-Maximilians-Universität Würzburg bietet Stelle als Universitätsprofessorin / Universitätsprofessor (m/w/d) für Pflanzengenetik (W3) in Würzburg - jetzt bewerben!

www.academics.de

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Andrea Sinz 🧪 @sinzandrea.bsky.social · 28d

The #BMSS2025 conference was a fantastic experience! 😀 It was so much fun to listen to such great talks, see so many wonderful posters and experience true enthusiasm for science. Glad I could share our latest XL-MS results with you!🙂🙃
#teammassspec #massspec #chemsky #academicsky

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