for fuck's sake
www.justice.gov/epstein/file...

It has not escaped our notice that this very amygdala-centric paper was just published in a journal called "Hippocampus"!

Huge thanks to @awheel-lab.bsky.social and @franklandlab.bsky.social and the rest of the crew for guidance.

Our 3D mapping reveals that the amygdala has a highly organized, hierarchical engram architecture.

Interestingly, we observed lots of similarities between the architecture of neurons engaged when mice recalled an aversive vs. a neutral memory, suggesting the amygdala engrams have similar architecture regardless of memory valence.

At the network level, we used graph theory and found that engram ensembles are structured networks with "hub" neurons. These hubs likely function as major communication centers for efficient memory recall.

At the micro-scale level, rather than being randomly distributed, we observed active neurons form tightly packed clusters. These local modules may be the building blocks that allow neurons to interact and stabilize the engram.

At the meso-scale, we identified specific spatial hotspots of high engram neuron density that are differentially engaged during fear learning and retrieval across different amygdala nuclei