We previously demonstrated neutrophil MPO derived HOCl targets the vinyl ether bond of plasmalogens resulting in the Liberation of 2-chlorofatty aldehydes (2-ClFALDs) and their oxidation products, 2-c...

Microgels are increasingly recognized as versatile building blocks for granular cell scaffolds, offering advantages over bulk hydrogels for a variety of biomedical applications. While existing method...

So excited to share our latest work uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization. Using patient serum, human dorsal root ganglia (DRG), and rat models, we show that FGFR...

In September 2025, the Kissick Family Foundation, in partnership with the Milken Institute Science Philanthropy Accelerator for Research and Collaboration (SPAR

In this paper, we undertook an in-depth investigation of the parameters that can be optimized to create FDM-based devices (both static and fluidic) that are leak-free and can be used for cell culture. Two different types of FDM printers (Stratasys Fortus 250mc and Bambu Lab P1S/X1-carbon) were utilized and devices were printed with a polystyrene filament, since this polymer is commonly used to make cell culture flasks. Stratasys-printed devices were made leak-free by increasing the negative “air gap” values to offset the toolpath, which significantly minimized voids between layers. Bambu Lab-based devices exhibited no leakage when printed with the ironing variable enabled. These parameters were optimized based on the design (static vs. fluidic), and the final devices were able to withstand leakage when subjected to flow experiments. It was found that these devices led to the successful culture of bovine pulmonary artery endothelial cells and Madin-Darby canine kidney cells, and a comparison was made to culturing these cells on a PolyJet-based device (printed with VeroClear material). NMR analysis was employed to determine if any potential leachates of polystyrene resulted after printing of the devices. Finally, fiber scaffolds were integrated into devices to mimic extracellular matrix (ECM) and to demonstrate the ability to perform cell culture under flow conditions in such devices. It is clear that with the developed settings, robust fluidic devices for cell culture can be created and used for the successful culture of endothelial and epithelial cells. Graphical Abstract

Cannabidiol (CBD) has gained a lot of interest in recent years for its purported medicinal properties. CBD has been investigated for the treatment of anxiety, depression, epilepsy, neuroinflammation, ...

continuation and severely affects life quality with no FDA-approved interventions. We previously reported that platinum-based drugs increase levels of sphingosine 1-phosphate (S1P) in the spinal cord ...

Abstract. Moderating the pool of active ribosomal subunits is critical for maintaining global translation rates. A factor crucial for modulating the 60S ri

reverses behavioral hypersensitivities in male rodents induced by chronic sciatic nerve constriction and chemotherapy (oxaliplatin and paclitaxel). Moreover, bilateral ozanimod injection in the rostra...

Author summary Hepatitis B virus (HBV) is a leading cause of liver cirrhosis, liver failure, and hepatocellular carcinoma worldwide. Current treatments reduce but do not eliminate disease progression, and they do not cure chronic HBV infections. We are pursuing the HBV ribonuclease H (RNase H) as a new drug target and identified N-hydroxypyridinediones (HPDs) as promising RNase H inhibitors. While exploring the effects of HPDs on cells, we found some of them had an unexpected second function of specifically eliminating empty HBV capsids without affecting levels of nucleocapsids that carry the viral genome. This secondary activity qualifies these HPDs as capsid assembly modulators (CAM), a promising class of drugs under development against HBV. The HPDs reduce capsid accumulation in part by slowing the rate of capsid assembly rather than accelerating it as do all other CAMs. This defines the HPDs as a new class of CAMs that we propose be called CAM-I, for CAM-inhibitors. The dual activity of CAM-I compounds may help promote HBV clearance in patients, particularly if the CAM function can be optimized to also target nucleocapsids that are the precursors to infection HBV virions.

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

Fungal infections remain a critical unmet medical need with millions of infections occurring annually. With only three classes of antifungal drugs available, drug resistance and modest activity toward...

We present an approach for integrating carbon ink electrodes into PolyJet three-dimensional (3D)-printed microfluidic devices for electrochemical (EC) detection. Devices for both microchip-based elec....

RNA-targeting therapies hold promise for contributing to HBV cure regimens, but challenges remain before that promise can be realized.