@smouillet.bsky.social
Reposted
NAD+ is a central molecule in bacterial immunity. An excellent and timely review by Hugo Vausset and Aude Bernheim
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
The multifaceted roles of NAD+ in bacterial immunity
In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide
(NAD+) is a key player in diverse and widespread bacterial antiphage defense systems
and phage counterdefense. The au...
www.cell.com
October 18, 2025 at 2:56 PM
NAD+ is a central molecule in bacterial immunity. An excellent and timely review by Hugo Vausset and Aude Bernheim
Reposted
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.
Lire le communiqué : presse.inserm.fr/une-proteine...
Lire le communiqué : presse.inserm.fr/une-proteine...
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité - Salle de presse de l'Inserm
Depuis quelques années, certains scientifiques explorent les liens inattendus entre les protéines humaines impliquées dans la défense de l’organisme et certains mécanismes immunitaires bactériens. C’e...
presse.inserm.fr
July 29, 2025 at 1:01 PM
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.
Lire le communiqué : presse.inserm.fr/une-proteine...
Lire le communiqué : presse.inserm.fr/une-proteine...
Reposted
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
Reposted
📣 Researchers from Institut Curie, @pasteur.fr and @inserm.fr have identified SIRal, a human protein of bacterial origin involved in innate immunity.
Co-led by @enzopoirier.bsky.social and @audeber.bsky.social, the study has just been published in @science.org
⬇️
www.science.org/doi/10.1126/...
Co-led by @enzopoirier.bsky.social and @audeber.bsky.social, the study has just been published in @science.org
⬇️
www.science.org/doi/10.1126/...
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
July 25, 2025 at 12:09 PM
📣 Researchers from Institut Curie, @pasteur.fr and @inserm.fr have identified SIRal, a human protein of bacterial origin involved in innate immunity.
Co-led by @enzopoirier.bsky.social and @audeber.bsky.social, the study has just been published in @science.org
⬇️
www.science.org/doi/10.1126/...
Co-led by @enzopoirier.bsky.social and @audeber.bsky.social, the study has just been published in @science.org
⬇️
www.science.org/doi/10.1126/...
Reposted
Wow - an important component of a central human innate immune pathway was discovered based on homology to a bacterial anti-phage defense system
A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health
A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 25, 2025 at 2:14 PM
Wow - an important component of a central human innate immune pathway was discovered based on homology to a bacterial anti-phage defense system
A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health
A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health
Reposted
Nature research paper: Activation of lysosomal iron triggers ferroptosis in cancer
https://go.nature.com/4jO9ZVX
https://go.nature.com/4jO9ZVX
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
go.nature.com
May 8, 2025 at 10:24 AM
Nature research paper: Activation of lysosomal iron triggers ferroptosis in cancer
https://go.nature.com/4jO9ZVX
https://go.nature.com/4jO9ZVX
Reposted
Cancer : Raphaël Rodriguez, le chercheur qui a trouvé la faille des métastases
➡️ https://l.lexpress.fr/8AJ
➡️ https://l.lexpress.fr/8AJ
May 17, 2025 at 2:21 PM
Cancer : Raphaël Rodriguez, le chercheur qui a trouvé la faille des métastases
➡️ https://l.lexpress.fr/8AJ
➡️ https://l.lexpress.fr/8AJ
Reposted
💊 Researchers at Institut Curie, @cnrs.fr and @inserm.fr have developed a prototype drug that destroys refractory cancer cells by degrading their membranes.
🎥 Dr Raphaël Rodriguez tells us more on video ⤵️
ℹ️ Read the scientific publication in Nature: www.nature.com/articles/s41...
🎥 Dr Raphaël Rodriguez tells us more on video ⤵️
ℹ️ Read the scientific publication in Nature: www.nature.com/articles/s41...
May 13, 2025 at 5:50 PM
💊 Researchers at Institut Curie, @cnrs.fr and @inserm.fr have developed a prototype drug that destroys refractory cancer cells by degrading their membranes.
🎥 Dr Raphaël Rodriguez tells us more on video ⤵️
ℹ️ Read the scientific publication in Nature: www.nature.com/articles/s41...
🎥 Dr Raphaël Rodriguez tells us more on video ⤵️
ℹ️ Read the scientific publication in Nature: www.nature.com/articles/s41...
Reposted
New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Webservice | DefenseFinder webservice and knowledge base
On this site, you can freely use (without any login) the DefenseFinder webservice (see below) and get help to navigate the ever expanding world of defense systems.There is a collaborative knowledge ba...
defensefinder.mdmlab.fr
February 19, 2025 at 4:28 AM
New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models