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Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT www.nature.com/articles/s41...
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT - Nature Communications
G6PT plays a vital role in glucose homeostasis by transporting glucose-6-phosphate to the lumen of ER. Here, authors present the cryo-EM structures of human G6PT in distinct forms, revealing the struc...
www.nature.com
November 15, 2025 at 10:09 PM
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT www.nature.com/articles/s41...
Structure of nanobody-inhibited state of human bile salt transporter NTCP www.cell.com/structure/fu...
Structure of nanobody-inhibited state of human bile salt transporter NTCP
NTCP is essential for hepatic bile acid uptake and circulation. Yoon et al. present
a high-resolution structure of NTCP in an inactive state with two bound sodium ions.
Combined with molecular dynamic...
www.cell.com
November 15, 2025 at 10:07 PM
Structure of nanobody-inhibited state of human bile salt transporter NTCP www.cell.com/structure/fu...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis www.cell.com/cell-metabol...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and
SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as
a key mediator of mitochondrial impo...
www.cell.com
November 9, 2025 at 4:51 PM
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis www.cell.com/cell-metabol...
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis www.cell.com/molecular-ce...
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial
import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine
drives carniti...
www.cell.com
November 9, 2025 at 10:54 AM
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis www.cell.com/molecular-ce...