💡This direct conversion method offers a promising alternative to traditional approaches involving iPSCs, simplifying the process and reducing the risks associated with cellular differentiation. 💡Could the same process be done for other critical cells involved in longevity? 🤔🤩

This model could help identify the most practical/easiest modifications.

To scientifically validate the accuracy of our model, we plan to test it against large datasets from thousands of mammals and animals. By comparing the model’s predictions with real biological data. 3/3

to identify homeostatic strategies (biological balance) that promote longevity.

AND…🧐
To assess how this model applies biologically.

Key insight: If different pathways lead to the same result, some cellular modifications in humans may be easier to apply.

Why it matters…2/3

The potential of these cells is immense, and we are excited to continue this research. (10/10)

For those who want to delve deeper into the topic, here are the two recent studies that have influenced our research:

Study 1: MSCs and knee regeneration
journals.sagepub.com/doi/10.1177/...

Study 2: MSCs and optic nerve repair in glaucoma
journals.sagepub.com/doi/10.1177/...
(9/10)

We are now exploring how far MSCs can go in rejuvenating different parts of the body. Their immune compatibility and regenerative power make them truly fascinating!

Regenerative medicine is evolving fast! MSC research brings us one step closer to future breakthroughs in healing and longevity.(8/10)

What’s remarkable is that MSCs don’t just replace damaged cells, they stimulate repair and regeneration, particularly in nerve-related injuries. Their potential in neurodegenerative diseases is fascinating! (7/10)

Another study suggests that MSCs could be a safer approach than epigenetic reprogramming to slow glaucoma progression and support vision. However, they don’t restore vision in the same way. (6/10)

In this study, the MSCs were even genetically modified to treat a specific condition.

But what interests us the most is that they were rejuvenated before being reintroduced into the body. This opens up incredible possibilities. (5/10)

MSCs have been studied for knee repair! One study showed that injecting MSCs into damaged joints promoted cartilage regeneration and improved mobility.

The results showed improved joint function and reduced pain. (4/10)

One amazing property of MSCs: they bypass the immune system! This means donor stem cells can be used without major rejection risks, making them ideal for regenerative medicine. (3/10)

I truly admire your work! 👏👏

MSCs can be obtained from umbilical cords or grown in labs, but most studies use umbilical cord MSCs for a simple reason: they are more cost-effective.

What makes them truly fascinating is how they interact with the human body. (2/10)

Hi! 🙃

3/3 I was thinking that if we could reintroduce younger cells into our body from rejuvenated stem cells, we could also, with these kinds of minimally invasive technologies, target and destroy older cells. But, well, I said this without having investigated the matter in detail. 🤷‍♀️🙃😉

2/3 For instance, in cases of significant weight loss. Of course, clinical trials would likely be necessary to explore this possibility, and the process would probably be quite complex. Worth investigating? 🤔