The birth, maturation, and integration of new neurons in the adult hippocampus regulates specific learning and memory processes, responses to stress, and antide...

Abstract. Athletes commonly exhibit a series of electrical, structural, and functional physiological changes which may overlap with cardiac pathology. The

Acute myocardial infarction (AMI) remains the leading form of cardiovascular morbidity and mortality, while exercise is a preventative and therapeutic…

The study investigated whether bicycle compared with car commuting, over relatively small distances, has positive effects on physiological variables, cardiometabolic fitness and CO2 output in the atm...

Guidelines evaluate and summarize available evidence with the aim of assisting health professionals in proposing the best diagnostic or therapeutic approac

The International Consensus Conference “Optimising Performance of the Elite Athlete,” held in November 2024, brought together 29 scientists, some coaches, and athletes to establish evidence-based con...

AbstractAims. Hypertrophic cardiomyopathy (HCM) is associated with functional limitations during exercise. We aimed to evaluate oxygen pulse (O2p) as a str

Step incremental exercise tests are widely used to assess endurance performance determinants; however, to what extent step duration influences oxygen uptake (V̇O2) and carbon dioxide production (V̇CO...

Methods Using a randomized crossover design, 30 well-trained male cyclists (maximal oxygen consumption (V̇O2max), 70.5 (4.6) mL·min−1·kg−1) completed both MITblock and REG. The MIT microcycle involv...

After finishing runner-up at the Tour de France Femmes for the second consecutive year, Demi Vollering reflected on the race and responded to criticism of…

For the smaller teams at the race, reaching the end is a goal in itself

AbstractAims. This study aims to evaluate outcomes and resource utilization of pre-participation screening (PPS) in a cohort of young (≤18 years), adult (1

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice and presents a significant and growing public health challenge. In a rigorously conducted Coch...

While humans evolved to perform routine endurance activity, recent secular trends in the United States and globally have resulted in a dramatic rise in the amount of time spent inactive in both occupa...

We read with great interest the study by Palau et al.,1 and was very insightful. The study shows that the modern cardiac rehabilitations deal with more spe

Auf Zeitfahr-Enttäuschung folgte der Triumph im Straßenrennen der Europäischen Jugendspiele

The athlete’s heart, formally introduced by Henschen and Darling in 1899 through observations of cardiac enlargement in endurance athletes, has evolved from a clinical curiosity to a recognized physio...

Guidelines for aerobic exercise training (AET) often recommend training intensities on the basis of a percentage of peak effort (e.g. %peak heart rate [%HR_peak], %peak oxygen uptake [%VO<su...

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Cardiorespiratory fitness (commonly assessed as maximal oxygen consumption, V̇O2max) is an independent predictor of risk for cardiovascular disease-related mortality. Endurance exercise training is recognized as a clinically validated intervention to significantly increase V̇O2max, and growing evidence exists demonstrating a tight connection between endurance training intensity domain and changes in V̇O2max. However, whether the vascular adaptations to exercise training are also influenced by intensity domains is unknown. Also unknown is the potential influence of sex on these responses. Thus, we assessed domain-specific hemodynamic and lower limb vascular adaptations in seventy healthy sedentary adults (35 females and 35 males) that underwent 6 weeks of endurance exercise training within five (n=14 per group; 7 females and 7 males) intensity domains: moderate, MOD; lower heavy intensity, HVY1; upper heavy-intensity, HVY2; high-intensity interval training in the severe domain, HIIT; sprint-interval training in the extreme domain (SIT). We found that: i) HIIT was associated with greater changes in resting hemodynamics (i.e., increased in resting mean arterial pressure and femoral artery vascular conductance) compared to MOD; ii) changes in V̇O2max were positively associated with changes in resting vascular conductance, femoral artery diameter, and indexes of reactive hyperemia while negatively associated with femoral artery flow-mediated dilation in females; iii) sex-related associations between changes in V̇O2max and peripheral vascular adaptations were more evident in response to HIIT. Taken together, our findings indicate that peripheral vascular adaptations associated with changes in cardiorespiratory fitness are impacted by sex and the exercise intensity domain within which training is performed.

Objective Regular physical exercise has well-known health benefits and is generally considered safe for adults with congenital heart disease (ACHD). However, many individuals with ACHD remain insuffic...