Srijita Banerjee
@srijita19.bsky.social
PhD student, Neural Organoids, pediatric brain cancer
Diffuse Midline Glioma is one of the most aggressive childhood brain tumors, with very limited treatment options.
They are known to have signature mutations in histone 3 variants. Additional mutations also include PDGFRA, TP53, ACVR1 and PI3K mutations #ISRVT25
They are known to have signature mutations in histone 3 variants. Additional mutations also include PDGFRA, TP53, ACVR1 and PI3K mutations #ISRVT25
March 17, 2025 at 3:32 PM
Diffuse Midline Glioma is one of the most aggressive childhood brain tumors, with very limited treatment options.
They are known to have signature mutations in histone 3 variants. Additional mutations also include PDGFRA, TP53, ACVR1 and PI3K mutations #ISRVT25
They are known to have signature mutations in histone 3 variants. Additional mutations also include PDGFRA, TP53, ACVR1 and PI3K mutations #ISRVT25
Did you know co-culturing iPSC-derived brain organoids with microglia can help the organoids mature faster? This was a great, crisp paper I came across.
#ISRVT25
www.nature.com/articles/s41...
#ISRVT25
www.nature.com/articles/s41...
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer - Nature
The authors seek to understand the precise roles of microglia in the early human brain by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent ...
www.nature.com
March 17, 2025 at 2:48 PM
Did you know co-culturing iPSC-derived brain organoids with microglia can help the organoids mature faster? This was a great, crisp paper I came across.
#ISRVT25
www.nature.com/articles/s41...
#ISRVT25
www.nature.com/articles/s41...
Quite an interesting article on targeting PDGFRA altered High-Grade Glioma
#ISRVT25
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib: Cancer Cell www.cell.com/cancer-cell/...
#ISRVT25
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib: Cancer Cell www.cell.com/cancer-cell/...
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT
inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival
benefit in pre-clinical H3K27M...
www.cell.com
March 17, 2025 at 2:38 PM
Quite an interesting article on targeting PDGFRA altered High-Grade Glioma
#ISRVT25
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib: Cancer Cell www.cell.com/cancer-cell/...
#ISRVT25
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib: Cancer Cell www.cell.com/cancer-cell/...