Paul Knoepfler
@stemcells.bsky.social
Professor at UC Davis studying cancer & stem cell epigenomics. I also do outreach and blog The Niche http://ipscell.com Also stem cell YouTube channel http://cutt.ly/vcsev4J STAT column https://www.statnews.com/category/lab-dish-paul-knoepfler/
I'm planning to write more about this unproven & unapproved gene therapy (oligo-based) widely marketed in the US by clinics. I don't see how the FDA hasn't acted on the US clinics selling SOT therapy or Q-REstrain here ipscell.com/2024/03/us-c...
January 3, 2026 at 4:13 AM
I'm planning to write more about this unproven & unapproved gene therapy (oligo-based) widely marketed in the US by clinics. I don't see how the FDA hasn't acted on the US clinics selling SOT therapy or Q-REstrain here ipscell.com/2024/03/us-c...
ICYMI: Colossal Biosciences wins 2025 The Screamers Award for science hype on incorrect dire wolf de-extinction claim ipscell.com/2025/12/colo... #stemcells #genetics
January 1, 2026 at 7:01 PM
ICYMI: Colossal Biosciences wins 2025 The Screamers Award for science hype on incorrect dire wolf de-extinction claim ipscell.com/2025/12/colo... #stemcells #genetics
Red-shouldered hawk. Love the wing pattern
December 25, 2025 at 9:28 PM
Red-shouldered hawk. Love the wing pattern
Random observation of the week. I found these 23-year-old rolls of lab tape in a plastic bag tucked into a binder in going through some old stuff. They still work perfectly despite being older than the undergrads in my lab
December 13, 2025 at 3:35 AM
Random observation of the week. I found these 23-year-old rolls of lab tape in a plastic bag tucked into a binder in going through some old stuff. They still work perfectly despite being older than the undergrads in my lab
Amazing pair of phainopepla calling to each other during the sunrise
November 9, 2025 at 6:07 PM
Amazing pair of phainopepla calling to each other during the sunrise
The cover of the Korean edition of my and my daughter's How to Build a Dragon book looks cool #CRISPR #stemcells www.amazon.com/How-Build-Dr...
October 31, 2025 at 6:43 PM
The cover of the Korean edition of my and my daughter's How to Build a Dragon book looks cool #CRISPR #stemcells www.amazon.com/How-Build-Dr...
Pistache trees putting on shows now in Davis, CA
October 24, 2025 at 7:34 PM
Pistache trees putting on shows now in Davis, CA
2 more recent birds: fairly common around here in fall but still showy, Spotted Towhee and relatively rare, dramatic Phainopepla
October 19, 2025 at 8:25 PM
2 more recent birds: fairly common around here in fall but still showy, Spotted Towhee and relatively rare, dramatic Phainopepla
Red-shouldered hawk at sunrise in Davis, CA
October 18, 2025 at 6:22 PM
Red-shouldered hawk at sunrise in Davis, CA
I found this big one on our tomato plants a few years back.
October 5, 2025 at 7:47 PM
I found this big one on our tomato plants a few years back.
Hiking & birding up in Yosemite. Despite the smoke, saw 3 lifers. Williamson sapsucker, White-headed woodpecker and a flock of Band-tailed pigeons. The Williamson was so cool! Smoke not so much.
September 17, 2025 at 1:19 AM
Hiking & birding up in Yosemite. Despite the smoke, saw 3 lifers. Williamson sapsucker, White-headed woodpecker and a flock of Band-tailed pigeons. The Williamson was so cool! Smoke not so much.
Woman dies after unproven regenerative medicine (adipose "stem cells") at clinic in Japan ipscell.com/2025/09/woma... both US and Japanese oversight systems are discussed and need improvement #stemcells #stemcell
September 11, 2025 at 6:32 PM
Woman dies after unproven regenerative medicine (adipose "stem cells") at clinic in Japan ipscell.com/2025/09/woma... both US and Japanese oversight systems are discussed and need improvement #stemcells #stemcell
Valley Carpenter Bee (Xylocopa sonorina) covered in pollen on a passionflower. It's been a great year for passionfruit
September 10, 2025 at 3:13 PM
Valley Carpenter Bee (Xylocopa sonorina) covered in pollen on a passionflower. It's been a great year for passionfruit
Weekend #stemcell & regenerative reads: immunosuppression & brain cell therapies including for Parkinson's, big pharma sucking up to Trump, NK cells ipscell.com/2025/09/week... #stemcells
September 7, 2025 at 1:57 PM
Weekend #stemcell & regenerative reads: immunosuppression & brain cell therapies including for Parkinson's, big pharma sucking up to Trump, NK cells ipscell.com/2025/09/week... #stemcells
Just hanging out on a Sunday morning with my pal watching the crazy birders walk by
August 10, 2025 at 4:03 PM
Just hanging out on a Sunday morning with my pal watching the crazy birders walk by
ICYMI: Q&A with the doc who gave RFK Jr. stem cells including on the FDA, his clinic offerings, & arena’s future ipscell.com/2025/07/qa-w... #stemcells #stemcell
July 25, 2025 at 6:48 PM
ICYMI: Q&A with the doc who gave RFK Jr. stem cells including on the FDA, his clinic offerings, & arena’s future ipscell.com/2025/07/qa-w... #stemcells #stemcell
Sign of the times.
July 15, 2025 at 8:49 PM
Sign of the times.
Fun variety of tomatoes from the garden. The green-blue ones have a hint of berry flavor
July 13, 2025 at 3:42 PM
Fun variety of tomatoes from the garden. The green-blue ones have a hint of berry flavor
2 plants I started from seed in early March from the same packet have very different traits. One is making cocktail-type tomatoes (between cherry and full-sized); other is making huge Roma-style tomatoes. Both seem great but so different #gardening
July 3, 2025 at 8:58 PM
2 plants I started from seed in early March from the same packet have very different traits. One is making cocktail-type tomatoes (between cherry and full-sized); other is making huge Roma-style tomatoes. Both seem great but so different #gardening
Quick take: some skepticism as Shift Bioscience reports secret purported rejuvenation gene SB000 in preprint. Claims of better vs. Yamanaka factors for some readouts, no in vivo data, etc. ipscell.com/2025/06/some... #stemcells #stemcell Longevity space is looking for big discoveries
June 11, 2025 at 8:18 PM
Quick take: some skepticism as Shift Bioscience reports secret purported rejuvenation gene SB000 in preprint. Claims of better vs. Yamanaka factors for some readouts, no in vivo data, etc. ipscell.com/2025/06/some... #stemcells #stemcell Longevity space is looking for big discoveries
Very cooperative Black-headed Grosbeak at Lake Solano Park in Yolo County
June 8, 2025 at 5:19 PM
Very cooperative Black-headed Grosbeak at Lake Solano Park in Yolo County
Weekly reads: coming cell and gene therapy deregulation, axed grant database, H3.3 in mESCs, remembering #stemcell pioneer James Till ipscell.com/2025/06/week... #stemcells #CRISPR
June 8, 2025 at 1:30 PM
Weekly reads: coming cell and gene therapy deregulation, axed grant database, H3.3 in mESCs, remembering #stemcell pioneer James Till ipscell.com/2025/06/week... #stemcells #CRISPR
ICYMI: First 2 biologics warnings from the Trump 2.0 FDA are interesting. Sign of hope for solid oversight? ipscell.com/2025/05/read... #stemcell
May 31, 2025 at 12:09 AM
ICYMI: First 2 biologics warnings from the Trump 2.0 FDA are interesting. Sign of hope for solid oversight? ipscell.com/2025/05/read... #stemcell
Surprise as I'm reading the stem cell tea leaves as Trump FDA issues first biologics warnings: to 2 perinatal biologics firms including Supreme Rejuvenation ipscell.com/2025/05/read... #stemcells #stemcell
May 29, 2025 at 7:39 PM
Surprise as I'm reading the stem cell tea leaves as Trump FDA issues first biologics warnings: to 2 perinatal biologics firms including Supreme Rejuvenation ipscell.com/2025/05/read... #stemcells #stemcell