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Steve Quinn @steve-quinn-lab.bsky.social · 6d

We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org!
👇
opg.optica.org/optica/fullt...

Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!

Optica Publishing Group

opg.optica.org

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Steve Quinn @steve-quinn-lab.bsky.social · 9d

Congratulations to Dr Fran D'Rozario from our @york.ac.uk team for successfully defending her thesis! Thanks also to Prof Paula Mendes & @bpsiyork.bsky.social for examining, and to Prof Steve Johnson for supervising. Well done Fran!

a congratulations card with a graduation cap

ALT: a congratulations card with a graduation cap

media.tenor.com

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Steve Quinn @steve-quinn-lab.bsky.social · 9d

New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript!
👇👇
www.biorxiv.org/content/10.1...

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Detergent-induced membrane solubilization is important for several biotechnological applications including membrane protein isolation, cell lysis and virus inactivation. The thermodynamic details of t...

www.biorxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Aug 19

Thanks to @ybri-uoy.bsky.social & @york.ac.uk .ac.uk for support & @alzheimerssoc.bsky.social @alzheimersresearchuk.org & @ukri.org for funding! Thanks also to researchers Katie, Guilherme, Augusto and Sian for running the experiments!

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Steve Quinn @steve-quinn-lab.bsky.social · Aug 19

We are delighted to announce that our latest work - a handheld photonic biosensor for Alzheimer's disease blood biomarkers - has been accepted for publication in Optica! Check out the pre-print...
👇👇
arxiv.org/abs/2504.08476
...and BBC story below:
www.bbc.co.uk/news/uk-engl...

arxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 30

Thanks also to the utterly superb facilities @biologyatyork.bsky.social led by @yorkbioimaging.bsky.social & to the funders @ukri.org, DiMeN DTP, & @wellcometrust.bsky.social!

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 30

Congratulations to Dr Sarah Graham for leading, with huge thanks to @chillzaa.bsky.social & @jemmabetts.bsky.social & #singlemolecule specialists
@timcraggs.bsky.social & @bpsiyork.bsky.social
Thanks also to @ybri-uoy.bsky.social @biologyatyork.bsky.social & to the team @ei-science.bsky.social.

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 30

🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬
👉 biorxiv.org/content/10.1...

#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid

A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation

Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...

biorxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 28

Thanks to
@ybri-uoy.bsky.social, EPSRC, @ei-science.bsky.social, @yorkbioimaging.bsky.social, @yorkbioscience.bsky.social for making #smFRET capabilities possible!

Steve Quinn @steve-quinn-lab.bsky.social · Jul 28

🧬New Pre-Print!🧬 PhD candidate Fran D'Rozario explores how pH-sensitive DNA triplexes retain reversible switching in solution, and when densely immobilized on surfaces - a step towards hybrid electronic DNA devices?
👇👇
biorxiv.org/content/10.1...

#DNAnanotech #bioelectronics #smFRET #DNAmachines

Electronic Actuation of Surface-Immobilized, pH-Responsive DNA Nanoswitches

Dynamic DNA machines exploit the specificity of base pairing and/or sensitivity to the local environment to control the reversible switching of DNA constructs between conformational states. One such e...

biorxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 23

New job opportunity! The Lindemann Trust
is recruiting 2 freelance roles: a Trusts and Grants Fundraiser and Philanthropy Events Fundraiser. For more info, and to apply, visit:
lindemanntrust.co.uk/support/
Closing date: Tuesday 19th August.

Support - The Lindemann Fellowship Administrative Trust

Support If you are interested in supporting our activities, either through sponsorship or by volunteering your time, we would love to hear from you. Below are just a few examples of ways you might be ...

lindemanntrust.co.uk

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Steve Quinn @steve-quinn-lab.bsky.social · Jul 21

🚨New Preprint! Latest research led by
@jemmabetts.bsky.social & @chillzaa.bsky.social
reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬

Chris H. Hill @chillzaa.bsky.social · Jul 19

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨

www.biorxiv.org/content/10.1...

A new protein-dependent riboswitch activates ribosomal frameshifting

Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...

www.biorxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Jun 2

Congratulations to Dr Sarah Graham @york.ac.uk #Physicsoflife group for successfully defending her thesis!
Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!

a cartoon of snoopy jumping with the words yay congratulations below him

ALT: a cartoon of snoopy jumping with the words yay congratulations below him

media.tenor.com

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 27

The heat was brutal, and the second half was gruelling. So chuffed to have made it through the 26.2 miles! Thanks London and @alzheimersresearchuk.org that was a blast!

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 27

Well done Selina!! Congratulations! Hope you’re not in too much pain!

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 26

Same to you Selina!! Have a brilliant run and amazing birthday! Hope to see you on the course and after party!

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 26

26.2 hours until until I take on #londonmarathon2025 , running for @AlzResearchUK ! Every step is for a future free from dementia. Let’s do this!

justgiving.com/page/runlabrun

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 14

Far, far, too real! Let's hope the rain stays away!

Steve Quinn @steve-quinn-lab.bsky.social · Apr 14

We are excited to share our latest pre-print, now available on
@arxiv.bsky.social: our latest photonic biosensing platform for blood-based Alzheimer's Disease biomarker detection!

Check it out! 👇👇
arxiv.org/abs/2504.08476

@ybri-uoy.bsky.social

Ultrasensitive Alzheimer's Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors

The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for novel diagnostics. Although biomarker detection directly in patients' blood is now possible, ...

arxiv.org

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Steve Quinn @steve-quinn-lab.bsky.social · Apr 13

It’s finally time for the taper! My legs are delighted to share that they have completed the final long training run! London Marathon 2025 is just 2 weeks away! #inpain 🏃

Donations to @alzheimersresearchuk.org , who fund critical research are enormously appreciated!

justgiving.com/page/runlabrun

Steve's fundraiser for Alzheimer's Research UK

Help Steven Quinn raise money to support Alzheimer's Research UK

justgiving.com

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Steve Quinn @steve-quinn-lab.bsky.social · Mar 19

Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care?

Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k

#Biomarkers #Dementia #Diagnostics

The Urgent and Global Need for Democratized Blood-Based Biomarker Diagnostics in Alzheimer’s Disease

Alzheimer’s disease (AD) represents one of the most pressing healthcare challenges of the 21st century. As a leading cause of dementia, AD impacts over 55 million people worldwide, with this number pr...

tinyurl.com

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Steve Quinn @steve-quinn-lab.bsky.social · Mar 10

Excited to be running #londonmarathon 2025 in support of @alzheimersresearchuk.org! The charity does so much to support ground-breaking dementia research! Any support for their mission, however small, would be massively appreciated and treasured so much!

www.justgiving.com/page/runlabrun

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Reposted by Steve Quinn

Exciting Instruments @ei-science.bsky.social · Mar 4

🚨 Exciting Seminar coming up!

→ Unravelling the FLEXibility of DNA hairpins and novel RNA systems

with @timcraggs.bsky.social , Hermia Kung and @steve-quinn-lab.bsky.social

⏰ 11th March 2025 | 5 PM BST (12 PM ET)

🔥 Bonus: A roundtable discussion!

Register here: buff.ly/J5P2J8s

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Steve Quinn @steve-quinn-lab.bsky.social · Feb 24

We’re on the way to #Birmingham for #ARUKConf2025! Excited to showcase our latest tech for blood based biomarker analysis and learn more about the latest developments in #dementia research! Come chat with us - we’re a friendly bunch! 🔬📈📊🥼

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Reposted by Steve Quinn

Steve Quinn @steve-quinn-lab.bsky.social · Feb 7

We're all set for @biophysicalsoc.bsky.social
#bps2025! Come learn more about our team's biosensing innovations for blood-based biomarker detection! Katie will showcase a new nanopillar-based approach for multiplexed analysis of Alzheimer's biomarkers! Sunday Feb 16th @ 9.45! 📊🩸🧪

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