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stevecappell.bsky.social
Steve Cappell
@stevecappell.bsky.social
26 followers 55 following 2 posts
Tenure-track investigator @NIH. My lab is interested in the single-cell dynamics of cell cycle regulation. Views and comments are my own. https://ccr.cancer.gov/staff-directory/steven-d-cappellhttps://ccr.cancer.gov/staff-directory/steven-d-cappell
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theleelab.bsky.social
Mike Lee @theleelab.bsky.social · Aug 15
I’m excited to highlight our latest paper, just published in Cell 🎉

We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.

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www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...
www.cell.com
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stevecappell.bsky.social
Steve Cappell @stevecappell.bsky.social · Jul 30
Many thanks to our collaborators including Nicholas Brown, John Albeck, Michael Emanuele, and Jing Huang.
stevecappell.bsky.social
Steve Cappell @stevecappell.bsky.social · Jul 30
Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism.
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature
APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
www.nature.com
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