Steven A. Weissman
@steven-a-weissman.bsky.social
Process chemist (formerly @Merck); Boston sports fan; partial to pinot noir; former Editorial Advisory Board member at OPR&D; aspiring 4.0 level pickleballer
There is no organization that can function effectively with 5 leadership changes in 11 months, let alone the one most responsible for the review and approval of life-saving medicines in our country.
www.biospace.com/fda/covid-co...
www.biospace.com/fda/covid-co...
COVID Contrarian Tracy Beth Høeg Named as FDA’s Acting CDER Chief
Høeg is the fifth person to lead the Center for Drug Evaluation and Research this year.
www.biospace.com
December 4, 2025 at 4:14 PM
There is no organization that can function effectively with 5 leadership changes in 11 months, let alone the one most responsible for the review and approval of life-saving medicines in our country.
www.biospace.com/fda/covid-co...
www.biospace.com/fda/covid-co...
This is particularly egregious given the PDUFA revenues being generated,
www.pharmasalmanac.com/articles/sil...
www.pharmasalmanac.com/articles/sil...
Silence at the FDA: Biotechs Report Delays, Denied Meeting Requests Amid Staff Cuts
High turnover and staffing cuts at the FDA are slowing reviews, inspections, and pre-IND meetings — leaving biotechs facing costly delays, unexplained denials, and rising pressure to take innovation o...
www.pharmasalmanac.com
October 23, 2025 at 2:49 PM
This is particularly egregious given the PDUFA revenues being generated,
www.pharmasalmanac.com/articles/sil...
www.pharmasalmanac.com/articles/sil...
Nothing to see here....
Google is blocking AI searches for Trump and dementia
Google is blocking AI searches for Trump and dementia
With Biden, AI Mode will provide a summarized answer.
buff.ly
October 1, 2025 at 12:21 AM
Nothing to see here....
The carnage continues......Novo Nordisk dismisses 263 and BMS cuts 282 in New Jersey share.google/sI057Qel2Fhy...
In New Jersey, Novo Nordisk cuts 263 workers while BMS slashes 282 roles
Novo Nordisk is not wasting time beginning the layoffs it
share.google
September 18, 2025 at 12:52 AM
The carnage continues......Novo Nordisk dismisses 263 and BMS cuts 282 in New Jersey share.google/sI057Qel2Fhy...
In ‘biotech winter,’ Boston startups, jobs, and science are being swept away - The Boston Globe
Local companies have shut down or scaled back in the industry’s decline, threatening scientific progress on cancer, autoimmune disorders, and other diseases.
www.bostonglobe.com
September 15, 2025 at 10:49 PM
One of the most fascinating obits you'll ever read. A giant in his field.
www.nytimes.com/2025/09/07/s...
www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 7, 2025 at 11:38 PM
One of the most fascinating obits you'll ever read. A giant in his field.
www.nytimes.com/2025/09/07/s...
www.nytimes.com/2025/09/07/s...
The following are scientifically INCONSISTENT with an SUV striking JOK:
1. injuries to JOK
2. location of tail light fragments
3. location of JOK body
4. damage to JOK hoodie
5. damage to KR Lexus
Case closed. #karenread
#karenreadtrial
#freekarenread
1. injuries to JOK
2. location of tail light fragments
3. location of JOK body
4. damage to JOK hoodie
5. damage to KR Lexus
Case closed. #karenread
#karenreadtrial
#freekarenread
June 11, 2025 at 3:18 PM
The following are scientifically INCONSISTENT with an SUV striking JOK:
1. injuries to JOK
2. location of tail light fragments
3. location of JOK body
4. damage to JOK hoodie
5. damage to KR Lexus
Case closed. #karenread
#karenreadtrial
#freekarenread
1. injuries to JOK
2. location of tail light fragments
3. location of JOK body
4. damage to JOK hoodie
5. damage to KR Lexus
Case closed. #karenread
#karenreadtrial
#freekarenread
Reposted by Steven A. Weissman
The US National Science Foundation has terminated 1,042 active grants over the past 2 weeks, according to a list provided to C&EN by an internal NSF source, who insisted on anonymity out of fear of retribution. cen.acs.org/policy/resea... 🧪
NSF terminates over 1,000 grants in 2 weeks
Chemistry education researchers and others hit by cuts weigh appeals and lawsuits
cen.acs.org
May 3, 2025 at 1:56 PM
The US National Science Foundation has terminated 1,042 active grants over the past 2 weeks, according to a list provided to C&EN by an internal NSF source, who insisted on anonymity out of fear of retribution. cen.acs.org/policy/resea... 🧪
What can we expected from the FDA moving forward ? Insights from a VC leader in the field
www.linkedin.com/posts/bruceb...
www.linkedin.com/posts/bruceb...
FDA turmoil is creating huge uncertainty for biotech... so much… | Bruce Booth | 67 comments
FDA turmoil is creating huge uncertainty for biotech... so much institutional knowledge is being lost... and upheaval is never good for productivity.
One of… | 67 comments on LinkedIn
www.linkedin.com
April 2, 2025 at 2:21 PM
What can we expected from the FDA moving forward ? Insights from a VC leader in the field
www.linkedin.com/posts/bruceb...
www.linkedin.com/posts/bruceb...
Simply put, the health of every American is at greater risk today because of this.
April 1, 2025 at 5:24 PM
Simply put, the health of every American is at greater risk today because of this.
An important take from Bloomberg's Lisa Jarvis, bravo.
Big Pharma Needs to Get Off the Sidelines
The industry can’t continue to sit idly by while Robert F. Kennedy Jr. guts the nation’s public health agencies.
www.bloomberg.com
April 1, 2025 at 3:29 PM
An important take from Bloomberg's Lisa Jarvis, bravo.
The indiscriminate layoffs (aka 'RIF') at HHS have begun
www.linkedin.com/news/story/m...
www.linkedin.com/news/story/m...
Mass layoffs begin at HHS | LinkedIn
Health and Human Services began laying off workers Tuesday morning, including senior officials, Bloomberg reports, citing a memo from the department.
www.linkedin.com
April 1, 2025 at 3:23 PM
The indiscriminate layoffs (aka 'RIF') at HHS have begun
www.linkedin.com/news/story/m...
www.linkedin.com/news/story/m...
The unwarranted decimation of our scientific institutions continues with the following HHS jobs cuts: FDA :3500 workers; CDC: 2400 workers, NIH: 1220 workers.
insider.thefdagroup.com/p/tracking-m...
insider.thefdagroup.com/p/tracking-m...
Tracking Major Changes at the FDA: Your 3-Minute Explainer
Let's catch up on the news—there's a lot going on.
insider.thefdagroup.com
March 27, 2025 at 6:46 PM
The unwarranted decimation of our scientific institutions continues with the following HHS jobs cuts: FDA :3500 workers; CDC: 2400 workers, NIH: 1220 workers.
insider.thefdagroup.com/p/tracking-m...
insider.thefdagroup.com/p/tracking-m...
Eisai and Novertis trim headcount in NJ
njbiz.com/more-layoffs...
njbiz.com/more-layoffs...
More layoffs coming to NJ’s pharma sector
Along with Nutley-based Eisai, several other New Jersey-based giants in the space have conducted layoffs over the past few months, including Bristol Myers Squibb, Bayer and Johnson & Johnson.
njbiz.com
March 21, 2025 at 4:37 PM
Eisai and Novertis trim headcount in NJ
njbiz.com/more-layoffs...
njbiz.com/more-layoffs...
Welp, it only took 53 days for the rule of law to fall by the wayside.
March 16, 2025 at 8:30 PM
Welp, it only took 53 days for the rule of law to fall by the wayside.
This is egregious and unforgivable:
contrarian.substack.com/p/trumps-del...
contrarian.substack.com/p/trumps-del...
Trump’s deliberate destruction of biomedical research institutions
The actions have ground NIH to a halt and sent shockwaves through academia and the biomedical research institutions.
contrarian.substack.com
March 15, 2025 at 3:42 PM
This is egregious and unforgivable:
contrarian.substack.com/p/trumps-del...
contrarian.substack.com/p/trumps-del...
A bold strategy:
www.newswire.ca/news-release...
www.newswire.ca/news-release...
CordenPharma and Viking Therapeutics Sign Long-Term Strategic Partnership for Integrated Supply of GLP-1 Peptides, Injectables and Oral Formulations
/CNW/ -- CordenPharma, a leading Contract Development & Manufacturing Organization (CDMO) specializing in the supply of peptide APIs and peptide-based...
www.newswire.ca
March 14, 2025 at 8:04 PM
A bold strategy:
www.newswire.ca/news-release...
www.newswire.ca/news-release...
Reposted by Steven A. Weissman
🧪 The attack on science could have a generational effect. We risk losing a wave of early-career researchers to these cuts. And biomedical science in the US will be less ambitious, less competitive & lead to fewer breakthroughs. So much is at stake. My latest for @opinion.bloomberg.com (🎁 link):
NIH Cuts Create a Lost Generation of Scientists
Trump administration attacks on the National Institutes of Health mean biomedical research will become less ambitious, less competitive and result in fewer breakthroughs.
www.bloomberg.com
March 12, 2025 at 1:28 PM
🧪 The attack on science could have a generational effect. We risk losing a wave of early-career researchers to these cuts. And biomedical science in the US will be less ambitious, less competitive & lead to fewer breakthroughs. So much is at stake. My latest for @opinion.bloomberg.com (🎁 link):
Another clue in the origins of Alzheimer's disease
www.science.org/content/blog...
www.science.org/content/blog...
Neurodegeneration Might Come Down to RNA
www.science.org
February 24, 2025 at 7:37 PM
Another clue in the origins of Alzheimer's disease
www.science.org/content/blog...
www.science.org/content/blog...
The development story behind the second generation synthesis of Cognition Therapeutics' sigma-2 receptor modulator, zervimesine (CT1812) can be found here:
pubs.acs.org/doi/10.1021/...
#chemsky #OPRD
pubs.acs.org/doi/10.1021/...
#chemsky #OPRD
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies
A second-generation synthesis of CT1812, a sigma-2 receptor modulator (ligand), was developed from readily available starting materials to support late-stage clinical needs. An AIBN-induced thermal be...
pubs.acs.org
January 29, 2025 at 7:52 PM
The development story behind the second generation synthesis of Cognition Therapeutics' sigma-2 receptor modulator, zervimesine (CT1812) can be found here:
pubs.acs.org/doi/10.1021/...
#chemsky #OPRD
pubs.acs.org/doi/10.1021/...
#chemsky #OPRD